The effect of thymectomy on tooth-germ allografts in rats

Macedo-Sobrinho, Braz; Iranpour, B

doi:10.1016/0003-9969(71)90051-3

Cited by 2 publications

(4 citation statements)

References 18 publications

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“…Later inflammatory episodes comprise mainly mononuclear leukocytes and thus correspond to the classic allograft reaction which commences 4 to 5 days post-operatively and reaches a peak shortly afterwards. A similar time scale of infiltration of tooth allografts has been observed (Shulman 1964, Shulman & Valente 1965, Mincer & Jennings 1970, Shulman & Kalis 1970, Klein 1971, Macedo-Sobrinho & Iranpour 1971, Riviere et al 1971. On the other hand it has been observed that infiltration does not begin until 2 or 3 weeks after grafting (Ivanyi & Vacek 1964a) or even later (Ivanyi 1965a, Weinreb et al 1968).…”

Section: The Allograft Reactionsupporting

confidence: 61%

“…The subsequent behavior of the dental papilla and its derivatives in allogeneic environments is extremely variable and has led to much confusion. Similar behavior to autografted and isografted tissue has been reported; namely recovery and renewal of dentinogenesis (Fong & Agnew 1958, Hoffman 1960, Ivanyi 1965a, Hoffman 1966, 1967, Weinreb et al 1968, Macedo-Sobrinho & Iranpour 1971. A number of authors have also observed that fibrous replacement of the pulp takes place (Ivanyi & Vacek 1964a, Ivanyi 1965a, 1965b, Fong et al 1968, Mincer & Jennings 1970.…”

Section: Allograftsmentioning

confidence: 52%

“…A number of authors have also observed that fibrous replacement of the pulp takes place (Ivanyi & Vacek 1964a, Ivanyi 1965a, 1965b, Fong et al 1968, Mincer & Jennings 1970. In still other experiments the pulp appears to remain empty or is filled with cell debris and no further dentinogenesis is seen (Ivanyi 1965a, Weinreb et al 1968, Macedo-Sobrinho & Iranpour 1971, Riviere et al 1971, Atkinson 1975.…”

Section: Allograftsmentioning

confidence: 93%

“…Allogeneic teeth transplanted to thymectomized rats do not suffer infiltration but continue to grow normally, albeit at a slow rate (Oprisiu et al 1968). Orthotopic grafts of teeth to thymectomized mice may even erupt into the oral cavity whereas similar grafts in normal mice are infiltrated by mononuclear leukocytes by 7 days and subsequently show necrotic pulps and dentin resorption (Macedo-Sobrinho & Iranpour 1971). ATS appears to confer some degree of protection to tooth allografts which grow normally.…”

Section: Effects Of Thymectomy and Antilymphocyte Seramentioning

confidence: 99%

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Histopathological and immunological aspects of tooth transplantation

Atkinson

1978

J Oral Pathology Medicine

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Histopathological studies of teeth transplanted between genetically identical animals and to animals in which the immune response is suppressed or enhanced show that autografts and isografts degenerate but then are repaired, whereas allografts show a bewildering array of changes from almost total destruction to total repair. Some explanations for the repair of teeth in an immunologically hostile environment are put forward.The immunological aspects of tooth transplantation are also reviewed. Transplanted teeth stimulate an immune response from the host and are subject to the same rules of genetic relationship which apply to other tissues. Most components of the teeth are antigenic in isolation but only the pulp and periodontal ligament have so far been demonstrated to possess these properties //; vivo. Transplanted teeth also elicit antibody formation but the importance of antibodies in the rejection process is still disputed.It is concluded that teeth are not immunologically privileged tissues but will elicit cell mediated responses from allogeneic hosts and are subject to the same invasive destructive lesions as a result. The peculiar observations of repair of allogeneic teeth and delayed immune responses can be explained by considering the histopathology of transplanted teeth and their capacity for repair.Finally, the use of transplanted teeth to study odontogenesis and pathological entities such as odontogenic cysts and reparative dentin formation are briefly reviewed.

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Section: The Allograft Reactionsupporting

confidence: 61%

Section: Allograftsmentioning

confidence: 52%

Section: Allograftsmentioning

confidence: 93%

Section: Effects Of Thymectomy and Antilymphocyte Seramentioning

confidence: 99%

See 2 more Smart Citations

Histopathological and immunological aspects of tooth transplantation

Atkinson

1978

J Oral Pathology Medicine

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A histological study of tooth allografts transplanted to untreated and immunologically prepared mice

Atkinson

1975

J Oral Pathology Medicine

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Ten-day-old mouse teeth were grafted subcutaneously into adults of an unrelated strain which were either untreated or had rejected a skin graft from the same strain as the tooth donors. First set allografts degenerated rapidly after grafting and were only sparsely repopulated subsequently. No cell-mediated immune response was obsei-ved. In contrast, second set allografts were heavily infiltrated with mononuclear leukocytes which persisted throughout the study, although the coronal pulp was never involved. It was suggested that first set allografts did not suffer a cell-mediated response because rapid degeneration of the cellular components removed the immunogenie target tissue before the host response could be effected.

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The effect of thymectomy on tooth-germ allografts in rats

Cited by 2 publications

References 18 publications

Histopathological and immunological aspects of tooth transplantation

Histopathological and immunological aspects of tooth transplantation

A histological study of tooth allografts transplanted to untreated and immunologically prepared mice

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