The Effect of Thio-TEPA on Wound Healing

Administration of therapeutic dose levels of cyclophosphamide as a single dose or as daily treatmenta for 5 days during the perisurgical period resulted in a significant decrease in the strength of surgical skin wounds in mice as measured 21 days after surgery. Administration of a single dose of 200 mg/kg either at the time of surgery or u p to 4 days prior to or after surgery impaired 21-day wound strength, with the most extensive depression observed when the drug was given 1 or 2 days after surgery. Earlier stages of wound healing (day 3 or day 7) were not as sensitive to cyclophosphamide. Adriamycin in the therapeutic dosage range for mice did not significantly impair wound healing.This drug had an effect only at the LD,, dosage level. Combination treatment with cyclophosphamide plus adriamycin a t the time of surgery impaired Plday wound strength to a greater degree than observed with either agent alone, but did not significantly depreas wound strength 3 or 7 days after surgery. These studies indicate that dosage level, the time of drug administration relative to surgery, and the time at which wound strength measurements are made are important parameters in determination of the effects of antineoplastic agents on wound healing. 36:1277-1281, 1975.

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Factors That Influence the Therapeutic Response

Kennealey

Mitchell

1977

Chemotherapy

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The Effect of Thio-TEPA on Wound Healing

Cited by 16 publications

References 6 publications

Mitomycin and the Healing of Intestinal Anastomosis

Mitomycin and the Healing of Intestinal Anastomosis

Effects of cyclophosphamide and adriamycin on the healing of surgical wounds in mice

Factors That Influence the Therapeutic Response

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