“…The clearing occurs by plasma opsonization and subsequent sequestration from circulation5., 6., 7., 8.. By pegylation, a process of coating with long-chain polyethylene glycols (PEG), liposomes are camouflaged with layers of hydrophilic coatings to evade RES clearance and achieve long circulation in the body9., 10., 11., 12., 13., 14., 15., 16.. The successful marketing of Doxil ® , a pegylated liposomal doxorubicin product, represents a milestone in the development of parenteral liposomes 17 .…”