The effect of the water on the curcumin tautomerism: A quantitative approach

Manolova, Yana; Deneva, Vera; Antonov, L.; Drakalska, Elena; Momekova, Denitsa; Lambov, Nikolay

doi:10.1016/j.saa.2014.05.096

Cited by 181 publications

(152 citation statements)

References 35 publications

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“…Their total energies are compared in Table S1, indicating that the tautomeric keto-enol form is less stable than the original diketo form for all types of curcumin derivatives. This result is comparable to that obtained by Manolova et al [46]. In water, two keto groups of the original curcumin are expected to form hydrogen bonds with water molecules to be more stable in their hydrated structures.…”

Section: Stable Structures Of Curcumins and Their Complexes With App28supporting

confidence: 90%

Specific interactions between amyloid-β peptide and curcumin derivatives: Ab initio molecular simulations

Ishimura

Kadoya

Suzuki

et al. 2015

Chemical Physics Letters

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Section: Stable Structures Of Curcumins and Their Complexes With App28supporting

confidence: 90%

Specific interactions between amyloid-β peptide and curcumin derivatives: Ab initio molecular simulations

Ishimura

Kadoya

Suzuki

et al. 2015

Chemical Physics Letters

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“…The interest in curcumin [(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione] [1,2,3,4,5,6,7,8,9] has prompted many structural studies on this β-diketone tautomerism [10,11,12,13,14] as well as on the synthesis and structural studies of hemicurcuminoids, compounds resulting from the replacement of one styryl branch of curcumin (2-methoxy-4-vinylphenol) by a simpler group, for instance, a phenyl group [11,15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structure and biological activity of 3(5)-trifluoromethyl-1H-pyrazoles derived from hemicurcuminoids

Nieto

Cabildo

Cornago

et al. 2015

Journal of Molecular Structure

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“…Curcumin, a polyphenolic compound, has been successfully used for treatment of various diseases such as allergies, arthritis, diabetes, Alzheimer's disease and other chronic diseases Manolova et al, 2014). It has anti-oxidant potential, ability to inhibit cell signaling affect, various cellular enzymes, cell adhesion and angiogenesis which contribute to its biological activity.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the ameliorative potential of plant flavonoids and their nanocomposites in bleomycin induced idiopathic pulmonary fibrosis

Kar¹,

Biswas²,

Banerjee³

2016

Biomed Res Ther

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Abstract-Introduction: Pulmonary Fibrosis can severely disrupt lung function. The cause of Idiopathic Pulmonary Fibrosis (IPF) is still unclear. The treatment currently available for IPF provides minimal benefits. Bleomycin is used in research to induce experimental pulmonary fibrosis in animals. Plant flavonoids such as fisetin and curcumin are known for their anti-inflammatory properties. The aim was to demonstrate the path of physiological changes in bleomycin induced IPF and to further evaluate the reversal and ameliorative potentials of some plant flavonoids and their nanocomposites. Bleomycin administration is known to damage the lung epithelial cells resulting in lower cell numbers. Methods: The Balb/c mice were used as models for bleo-induced IPF. Inflammation was measured by the generation of ROS, RONI, and histological assessment. Cell proliferation was measured by MTS assay and CFU assay. Results: Our colony-forming assay in BALF also demonstrated a reduction (1.65 fold) in colony-forming unit after bleomycin administration. The number of colonies increased upon treatment with fisetin(1.20 fold) and curcumin (1.13 fold) respectively. MTT proliferation assay demonstrated a significant increase in the number of viable cells upon treatment with curcumin (1.42 fold) and fisetin (1.74 fold) respectively, in the lung. The NBT assay demonstrated a significant effect of curcumin in BALF, lung and peripheral blood. A significant effect of fisetin was observed in BALF and peripheral blood. Conclusion: These findings were also supported by the histological analyses of the lung samples. Curcumin showed highest potential for the treatment of IPF and fisetin showed its ameliorative effect.

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The effect of the water on the curcumin tautomerism: A quantitative approach

Cited by 181 publications

References 35 publications

Specific interactions between amyloid-β peptide and curcumin derivatives: Ab initio molecular simulations

Specific interactions between amyloid-β peptide and curcumin derivatives: Ab initio molecular simulations

Synthesis, structure and biological activity of 3(5)-trifluoromethyl-1H-pyrazoles derived from hemicurcuminoids

Evaluating the ameliorative potential of plant flavonoids and their nanocomposites in bleomycin induced idiopathic pulmonary fibrosis

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