The Effect of the Valsalva Manoeuvre on the Systemic and Pulmonary Arterial Pressure in Man

Lee, G. De J.; Matthews, Michael B.; Sharpey‐Schafer, E. P.

doi:10.1136/hrt.16.3.311

Cited by 83 publications

(24 citation statements)

References 13 publications

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“…The same conclusion, that, at non-toxic doses atropine 552 M. MANZOTTI HEART RATE AND RESPIRATORY MAN(EUVRES does not interfere with the H.R. in experiments of this type, can be drawn from the results reported by Lee, Matthews & Sharpey-Schafer (1954) Bjurstedt, Wood & Astr6m (1953) have found in the anaesthetized dog. However, Hamilton, Woodbury & Vogt (1939) seem to have been able to record from the unanaesthetized dog a H.R.…”

Section: Resultssupporting

confidence: 55%

“…The arterial blood pressure constantly showed an immediate drop to as low as 30-40 mm Hg for applied intrapulmonary pressures ranging from + 10 to + 40 cm of water. In man, when the intrapulmonary pressure is voluntarily raised, such a considerable initial drop of the arterial blood pressure is never present (Lee et al (1954); Judson, Hatcher & Wilkins (1955)). During application to our cats of negative intrapulmonary pressure alone no variation of the H.R.…”

Section: Resultsmentioning

confidence: 99%

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The effect of some respiratory manœuvres on the heart rate

Manzotti¹

1958

The Journal of Physiology

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That there is some form of interaction between respiration and heart rate (H.R.) is very old knowledge, but it was only in the third decade of this century that Heymans (1929), using his technique of the isolated head, studied this interaction, with particular reference to the respiratory arrhythmia.Sinus arrhythmia becomes very evident when the depth and frequency of respiration are increased as in recovery after exercise. Considering the possibility of sudden large changes in blood flow through the chest producing an alteration of the H.R., some respiratory manceuvres, designed to vary the blood flow through the intrathoracic pressure, have been worked through systematically. But the sudden variations in the H.R. could not have been readily studied on account of the difficulties involved in accurate recording. A new technique has, in fact, made it possible to demonstrate a delay of about 5 sec in the cessation and reappearance of sinus arrhythmia when the breath is held.Analysis of the results seems to show a causal relationship between some alterations in intrapulmonary pressure and changes in H.R. Explanation of the results seems to involve the arterial baroreceptors or, at any rate, the left side of the heart, as the site of origin of the stimulus, which appears to be change of blood flow. The same mechanism might be involved also during ordinary quiet respiration. METHODSThe human experiments were performed on a group of fifteen male subjects ranging from 18 to 31 years of age. The subjects practised in advance the type of experiment to be performed, but the timing of events was given by the experimenter.The H.R. was computed from the QRS complexes of the e.c.g., recorded between the left leg and the forehead. A cardiotachometer of suitable design (Manzotti, 1956a) displayed the heart rate on linear ordinates, beat by beat, with a constant delay of 10 m-sec. The accuracy was ± 2%.A dotted record was obtained, each dot corresponding to one beat.In some experiments the respiratory movements were stethographically recorded by tying * Present address: Department of Physiology, University of Milan.

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Section: Resultssupporting

confidence: 55%

Section: Resultsmentioning

confidence: 99%

The effect of some respiratory manœuvres on the heart rate

Manzotti¹

1958

The Journal of Physiology

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“…It has been shown that the effective pulmonary arterial pressure (i.e., in relation to intrapleural pressure) is raised during inspiration (2,7,8), whereas the effective left auricular pressure measured by others (as discussed in Reference 2) shows little change so that pressure difference between these vessels is therefore augmented during inspiration. The rise in effective pulmonary arterial pressure has been supposed by some (8) to be due entirely to the increased output of the right heart during inspiration, since it still occurs when sympathetic nerve action is blocked by tetraethyl ammonium bromide.…”

Section: Discussionmentioning

confidence: 99%

Measurements of Pulmonary Capillary Blood Flow and Gas Exchange Throughout the Respiratory Cycle in Man1

DuBois¹,

Marshall²

1957

J. Clin. Invest.

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“…Lee, Matthews, and Sharpey-Shafer (15) found that "net" pulmonary arterial wedge pressure (arterial pressure minus intraesophageal pressure) fell during a Valsalva and, after release, returned suddenly to control levels then gradually rose above the control (overshoot). Tachycardia occurred shortly after the release, and a bradycardia accompanied the overshoot.…”

Section: Resultsmentioning

confidence: 99%

A water-filled body plethysmograph for the measurement of pulmonary capillary blood flow during changes of intrathoracic pressure

Kawakami¹,

Menkes²,

DuBois³

1970

J. Clin. Invest.

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A B S T R A C T A water-filled body plethysmograph was constructed to measure gas exchange in man. As compared to an air-filled plethysmograph, its advantages were greater sensitivity, less thermal drift, and no change from adiabatic to isothermal conditions after a stepwise change of pressure. When five subjects were completely immersed within it and were breathing to the ambient atmosphere, they had a normal heart rate, oxygen consumption, CO2 output, and functional residual capacity. Pulmonary capillary blood flow (0c)

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The Effect of the Valsalva Manoeuvre on the Systemic and Pulmonary Arterial Pressure in Man

Cited by 83 publications

References 13 publications

The effect of some respiratory manœuvres on the heart rate

The effect of some respiratory manœuvres on the heart rate

Measurements of Pulmonary Capillary Blood Flow and Gas Exchange Throughout the Respiratory Cycle in Man1

A water-filled body plethysmograph for the measurement of pulmonary capillary blood flow during changes of intrathoracic pressure

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