The effect of the physicochemical properties of bioactive electroconductive hydrogels on the growth and proliferation of attachment dependent cells

Kotanen, Christian N.; Wilson, A. Nolan; Dong, Chenbo; Dinu, Cerasela Zoica; Justin, Gusphyl; Guiseppi‐Elie, Anthony

doi:10.1016/j.biomaterials.2013.05.022

Cited by 51 publications

(36 citation statements)

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“…Polymer-based biomaterials are promising candidates for biomedical applications such as three-dimensional tissue engineering scaffolds and drug carriers for controlled/sustained drug release [3]. Polymer biomaterials exhibit advantages such as biodegradation, biological responses, and controllable mechanical properties [3][4][5]. Compared with the conventional polymerbased biomaterials, the synthetic HAP materials have not only high biocompatibility and biological responses, but also show similar chemical properties to natural bone tissues.…”

Section: Introductionmentioning

confidence: 98%

Solvothermal synthesis of submillimeter ultralong hydroxyapatite nanowires using a calcium oleate precursor in a series of monohydroxy alcohols

Jiang

Zhu

Chen

et al. 2015

Ceramics International

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Section: Introductionmentioning

confidence: 98%

Solvothermal synthesis of submillimeter ultralong hydroxyapatite nanowires using a calcium oleate precursor in a series of monohydroxy alcohols

Jiang

Zhu

Chen

et al. 2015

Ceramics International

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“…[1][2][3] During cellular adhesion, cells alternately interact with materials via surface receptors that transduce external chemical signals or mechanical stimulation and eventually regulate the expression of specific genes and proteins. 4,5 Simultaneously, the transfer of internal activities relies greatly on external materials.…”

Section: Introductionmentioning

confidence: 99%

Nanoscale TiO2 nanotubes govern the biological behavior of human glioma and osteosarcoma cells

Tian¹,

Qin²,

Wu³

et al. 2015

IJN

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Cells respond to their surroundings through an interactive adhesion process that has direct effects on cell proliferation and migration. This research was designed to investigate the effects of TiO 2 nanotubes with different topographies and structures on the biological behavior of cultured cells. The results demonstrated that the nanotube diameter, rather than the crystalline structure of the coatings, was a major factor for the biological behavior of the cultured cells. The optimal diameter of the nanotubes was 20 nm for cell adhesion, migration, and proliferation in both glioma and osteosarcoma cells. The expression levels of vitronectin and phosphor-focal adhesion kinase were affected by the nanotube diameter; therefore, it is proposed that the responses of vitronectin and phosphor-focal adhesion kinase to the nanotube could modulate cell fate. In addition, the geometry and size of the nanotube coating could regulate the degree of expression of acetylated α-tubulin, thus indirectly modulating cell migration behavior. Moreover, the expression levels of apoptosis-associated proteins were influenced by the topography. In conclusion, a nanotube diameter of 20 nm was the critical threshold that upregulated the expression level of Bcl-2 and obviously decreased the expression levels of Bax and caspase-3. This information will be useful for future biomedical and clinical applications.

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“…Much of this attention is because of their high biocompatibility [5], attributed partially to their ability to imbibe large amounts of water [6], to mitigate denaturing protein adsorption, and because of their stimuli responsive nature [7], attributed partially to swelling-collapsing dynamics that are dependent on environmental conditions [8][9][10]. Because of the importance of diffusive transport in many aspects of molecular physiology, an area currently under investigation is the design and molecular engineering of the diffusive transport properties of small molecules and ions within the hydrogel matrix as a means towards control of expressed bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Release of Potassium Ion and Calcium Ion from Phosphorylcholine Group Bearing Hydrogels

et al. 2013

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Abstract:In an attempt to recreate the microenvironment necessary for directed hematopoietic stem cell differentiation, control over the amount of ions available to the cells is necessary. The release of potassium ion and calcium ion via the control of cross-linking density of a poly(2-hydroxyethyl methacrylate) (pHEMA)-based hydrogel containing 1 mol % 2-methacryloyloxyethyl phosphorylcholine (MPC) and 5 mol % oligo(ethylene glycol) (400) monomethacrylate [OEG(400)MA] was investigated. Tetra(ethylene glycol) diacrylate (TEGDA), the cross-linker, was varied over the range of 1-12 mol %. Hydrogel discs (ϕ = 4.5 mm and h = 2.0 mm) were formed by UV polymerization within silicone isolators to contain 1.0 M CaCl 2 and 0.1 M KCl, respectively. Isothermal release profiles, were measured at 37 °C in 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid sodium salt (HEPES) buffer using either calcium ion or potassium ion selective electrodes (ISE). The resulting release OPEN ACCESSPolymers 2013, 5 1242 profiles were found to be independent of cross-linking density. Average (n = 3) release profiles were fit to five different release models with the Korsmeyer-Peppas equation, a porous media transport model, exhibiting the greatest correlation (R 2 > 0.95). The diffusion exponent, n was calculated to be 0.24 ± 0.02 and 0.36 ± 0.04 for calcium ion and potassium ion respectively indicating non-Fickian diffusion. The resulting diffusion coefficients were calculated to be 2.6 × 10 −6 and 11.2 × 10 −6 cm 2 /s, which compare well to literature values of 2.25 × 10 −6 and 19.2 × 10 −6 cm 2 /s for calcium ion and potassium ion, respectively.

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The effect of the physicochemical properties of bioactive electroconductive hydrogels on the growth and proliferation of attachment dependent cells

Cited by 51 publications

References 50 publications

Solvothermal synthesis of submillimeter ultralong hydroxyapatite nanowires using a calcium oleate precursor in a series of monohydroxy alcohols

Solvothermal synthesis of submillimeter ultralong hydroxyapatite nanowires using a calcium oleate precursor in a series of monohydroxy alcohols

Nanoscale TiO2 nanotubes govern the biological behavior of human glioma and osteosarcoma cells

Release of Potassium Ion and Calcium Ion from Phosphorylcholine Group Bearing Hydrogels

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