The effect of the microstructure of β-tricalcium phosphate on the metabolism of subsequently formed bone tissue

Okuda, Takatoshi; Ioku, Koji; Yonezawa, Ikuho; Minagi, Hideyuki; Kawachi, Giichiro; Gonda, Yoshinori; Murayama, Hisashi; Shibata, Yasuaki; Minami, Soichiro; Kamihira, Shimeru; Kurosawa, Hisashi; Ikeda, Tohru

doi:10.1016/j.biomaterials.2007.01.040

Cited by 138 publications

(150 citation statements)

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“…7 Also, microstructural characteristics, such as micropores, to increase specific surface area and surface roughness affect resorption, mechanical properties, and healing. [8][9][10] Certain calcium phosphate ceramics are osteoinductive, being able to induce bone formation where bone does not naturally grow. 11 Despite recent successes of synthetic calcium phosphates, their performance requires improvement.…”

mentioning

confidence: 99%

Comparative in vivo study of six hydroxyapatite‐based bone graft substitutes

Habibović

Kruyt

Juhl

et al. 2008

Journal Orthopaedic Research

209

186

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Improvement of synthetic bone graft substitutes as suitable alternatives to a patient's own bone graft remains a challenge in biomaterials research. Our goal was to answer the question of whether improved osteoinductivity of a material would also translate to better bone-healing orthotopically. Three porous biphasic calcium phosphate (BCP) ceramics (BCPA, BCPB, and BCPC), consisting of hydroxyapatite and b-tricalcium phosphate, a porous biphasic calcium phosphate ceramic reinforced with a bioresorbable polylactic acid to improve its mechanical properties (BCPCþ), a pure hydroxyapatite ceramic (HA), and a carbonated apatite ceramic (CA) were implanted intramuscularly and orthotopically by using a transverse process model in 11 goats for 12 weeks. BCPA and BCPB had similar chemical composition but differed in their microstructure. BCPB was not osteoinductive at all, but BCPA induced ectopic bone formation in 9 of 11 animals. Orthotopically, BCPA performed better than BCPB in both the amount and rate of bone formation. BCPC, similar to BCPA structurally and physicochemically, showed comparable results ectopically and orthotopically. Addition of resorbable polymer to BCPC made the material less osteoinductive (4 of 11 animals) and delayed bone formation orthotopically. Neither HA nor CA were osteoinductive, and their orthotopic performance was inferior to the osteoinductive ceramics. The results of the present study showed that material-derived osteoinduction significantly enhanced bone healing orthotopically, and that this material property appeared more sensitive for predicting orthotopic performance than physicochemical and structural characteristics. ß

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mentioning

confidence: 99%

Comparative in vivo study of six hydroxyapatite‐based bone graft substitutes

Habibović

Kruyt

Juhl

et al. 2008

Journal Orthopaedic Research

209

186

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“…A mouse ectopic model study indicated the maximal bone growth for the 80 : 20 β-TCP : HA biphasic formulations preloaded with human mesenchymal stem cells when compared to other calcium orthophosphates [647]. The effects of substrate microstructure and crystallinity have been corroborated with an in vivo rabbit femur model, where rod-like crystalline β-TCP was reported to enhance osteogenesis when compared to non-rod like crystalline β-TCP [634]. Additionally, using a dog mandibular defect model, a higher bone formation on a scaffold surface coated by nanodimensional HA was observed when compared to that coated by a microdimensional HA [648].…”

Section: Bioactivitymentioning

confidence: 88%

“…Osteoblasts cultured on porous HA bioceramics appeared to exhibit a higher adhesion, an enhanced differentiation and suppressed proliferation rates when compared to the non-porous controls [643,644]. Furthermore, formation of distinct resorption pits on HA [645] and β-TCP [634] surfaces in the presence of osteoclasts was observed. Moreover, a surface roughness of calcium orthophosphate bioceramics was reported to strongly influence the activation of mononuclear precursors to mature osteoclasts [645].…”

Section: Bioactivitymentioning

confidence: 91%

“…In one study, an in vivo behavior of porous β-TCP bioceramics prepared from rod-shaped particles and that prepared from non-rodshaped particles in the rabbit femur was compared. Although the porosities of both types of β-TCP bioceramics were almost the same, a more active osteogenesis was preserved in the region where rodshaped bioceramics was implanted [634]. This result implied that the microstructure affected the activity of bone cells and subsequent bone replacement.…”

Section: Biodegradationmentioning

confidence: 94%

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2011

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…In addition to the porosity and the structure of micro and macro pores, microstructure of the particles composing the material has also been shown to be associated with the bioresorbability [1]. We have shown that the cylindrical block of β-TCP composed of unique rod-shaped particles behaved differently from the same-shaped block of conventional β-TCP composed of non rod-shaped particles when implanted into rabbit femurs, and proposed the hypothesis that bioresorbability of the bone substitute affected the metabolism of the subsequently formed bone tissue [2]. Previously, we also have developed spherical granules of β-TCP using a new unique method [3].…”

Section: Introductionmentioning

confidence: 94%

Osteoconductivity of Hydrothermally Synthesized Beta-Tricalcium Phosphate Composed of Rod-Shaped Particles under Mechanical Unloading

Gonda

Ioku

Okuda

et al. 2008

KEM

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Abstract. Spherical beta-tricalcium phosphate (β-TCP) granules synthesized using a unique dropping slurry method expressed good osteoconductivity with prominent bone apposition and bioresorbability when implanted into the rat femur (Gonda et al., Key Eng. Mater. 361-363:1013-1016. The spherical β-TCP granules were implanted into the bone defect created in the distal end of the right femur of each 8-week-old female Wistar rat. To analyze performance of the spherical β-TCP granules as bone substitute in the bone with reduction in osteogenic potential, the right sciatic neurectomy was performed after implantation and the right hind limb was kept unloaded for 2 weeks before euthanization. Four weeks after implantation, some spherical β-TCP granules with resorption in part were surrounded by newly formed bone. Eight and 12 weeks after implantation, most of the residual β-TCP granules were embedded in newly formed bone, and total volume of the implant and newly formed bone was more than the other portions of the bone or the bone of control animals. Osteoclast activity in the implanted area was also higher than the other portions of the bone or the bone of control animals. Replacement of the intraosseous residual β-TCP granules for bone progressed at 12 weeks after implantation compared to those at 8 weeks after implantation. These data suggested that the spherical β-TCP granules stimulated osteogenesis and osteoclast activity of the unloaded bone. IntroductionBeta-tricalcium phosphate (β-TCP) has been used clinically as a bioresorbable bone substitute. In addition to the porosity and the structure of micro and macro pores, microstructure of the particles composing the material has also been shown to be associated with the bioresorbability [1]. We have shown that the cylindrical block of β-TCP composed of unique rod-shaped particles behaved differently from the same-shaped block of conventional β-TCP composed of non rod-shaped particles when implanted into rabbit femurs, and proposed the hypothesis that bioresorbability of the bone substitute affected the metabolism of the subsequently formed bone tissue [2]. Previously, we also have developed spherical granules of β-TCP using a new unique method [3]. After implantation into rat femurs, both spherical β-TCP granules composed of rod-shaped particles produced by hydrothermal method and β-TCP granules composed of non rod-shaped particles revealed good osteoconductivity. Total volume of the newly formed bone and implant was similar

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The effect of the microstructure of β-tricalcium phosphate on the metabolism of subsequently formed bone tissue

Cited by 138 publications

References 26 publications

Comparative in vivo study of six hydroxyapatite‐based bone graft substitutes

Comparative in vivo study of six hydroxyapatite‐based bone graft substitutes

Untitled

Osteoconductivity of Hydrothermally Synthesized Beta-Tricalcium Phosphate Composed of Rod-Shaped Particles under Mechanical Unloading

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