The Effect of the Mediterranean Diet on Hypertension: A Systematic Review and Meta-Analysis

Nissensohn, Mariela; Román-Viñas, Blanca; Sánchez‐Villegas, Almudena; Piscopo, Suzanne; Serra-Majem, Lluís

doi:10.1016/j.jneb.2015.08.023

Cited by 123 publications

(68 citation statements)

References 28 publications

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“…The first meta-analysis included studies $12 mo long that had a low-fat control group. Although a significant reduction was shown for both systolic BP and diastolic BP, the authors remained unconvinced that the MedDiet lowers BP compared with the effect of a low-fat diet, which was mainly due to the heterogeneity and limited number of studies (n = 7) (29). Another meta-analysis investigated the effects of different dietary patterns and concluded that a MedDiet lowers systolic BP by 3 mm Hg and diastolic BP by 2 mm Hg (30).…”

Section: Discussionmentioning

confidence: 99%

A Mediterranean diet lowers blood pressure and improves endothelial function: results from the MedLey randomized intervention trial ,

Davis

Hodgson

Woodman

et al. 2017

The American Journal of Clinical Nutrition

151

118

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Background: The consumption of a Mediterranean diet (MedDiet) is associated with a lower risk of cardiovascular disease. However, its impact on blood pressure and endothelial function is not clear. Objective: We sought to determine the effects of adhering to the consumption of a MedDiet for 6 mo on blood pressure and endothelial function in older, healthy Australians. Design: A total of 166 men and women aged .64 y were allocated via minimization to consume either a MedDiet (n = 85) or their habitual diet (HabDiet; control: n = 81) for 6 mo. The MedDiet comprised mainly plant foods, abundant extra-virgin olive oil, and minimal red meat and processed foods. A total of 152 participants commenced the study, and 137 subjects completed the study. Home blood pressure was measured on 5 consecutive days at baseline (n = 149) and at 3 and 6 mo. Endothelial function (n = 82) was assessed by flow-meditated dilatation (FMD) at baseline and 6 mo. Dietary intake was monitored with the use of 3-d weighed food records. Data were analyzed with the use of linear mixed-effects models to determine adjusted between-group differences. Results: The MedDiet adherence score increased significantly in the MedDiet group but not in the HabDiet group (P , 0.001). The MedDiet, compared with the HabDiet, resulted in lower systolic blood pressure (P-diet 3 time interaction = 0.02) [mean: 21.3 mm Hg (95% CI: 22.2, 20.3 mm Hg; P = 0.008) at 3 mo and 21.1 mm Hg (95% CI: 22.0, 20.1 mm Hg; P = 0.03) at 6 mo]. At 6 mo, the percentage of FMD was higher by 1.3% (95% CI: 0.2%, 2.4%; P = 0.026) in the MedDiet group. Conclusion: Australian men and women who consumed a MedDiet for 6 mo had small but significantly lower systolic blood pressure and improved endothelial function. This trial was registered at www.anzctr.org.au as ACTRN12613000602729.Am J Clin Nutr 2017;105:1305-13.

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Section: Discussionmentioning

confidence: 99%

A Mediterranean diet lowers blood pressure and improves endothelial function: results from the MedLey randomized intervention trial ,

Davis

Hodgson

Woodman

et al. 2017

The American Journal of Clinical Nutrition

151

118

View full text Add to dashboard Cite

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“…The Mediterranean-style diet is an established healthy-eating diet pattern that has consistently demonstrated to have beneficial effects on musculoskeletal [2], cardiovascular [3], metabolic [4], and cognitive [5] diseases.…”

Section: Introductionmentioning

confidence: 99%

Adherence to a Mediterranean diet is associated with lower prevalence of osteoarthritis: Data from the osteoarthritis initiative

et al. 2017

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Summary Background & aims The Mediterranean diet appears to be beneficial for several medical conditions, but data regarding osteoarthritis (OA) are not available. The aim of this study was to investigate if adherence to the Mediterranean diet is associated with a lower prevalence of OA of the knee in a large cohort from North America. Methods 4358 community-dwelling participants (2527 females; mean age: 61.2 years) from the Osteoarthritis Initiative were included. Adherence to the Mediterranean diet was evaluated through a validated Mediterranean diet score (aMED) categorized into quartiles (Q). Knee OA was diagnosed both clinically and radiologically. The strength of the association between aMED (divided in quartiles) and knee OA was investigated through a logistic regression analysis and reported as odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounders. Results Participants with a higher adherence to Mediterranean diet had a significantly lower prevalence of knee OA compared to those with lower adherence (Q4: 25.2% vs. Q1: 33.8%; p < 0.0001). Using a logistic regression analysis, adjusting for 10 potential confounders with those in the lowest quartile of aMED as reference, participants with the highest aMED had a significant reduction in presence of knee OA (OR, 0.83; 95% CIs: 0.69–0.99, p = 0.04). Among the individual components of Mediterranean diet, only higher use of cereals was associated with lower odds of having knee OA (OR: 0.76; 95%CI: 0.60–0.98; p = 0.03). Conclusions Higher adherence to a Mediterranean diet is associated with lower prevalence of knee OA. This remained when adjusting for potential confounders.

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“…The Mediterranean diet is an established healthy eating behavior that has consistently and positively influenced musculoskeletal, cardiovascular, metabolic, and cognitive health (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Adherence to the Mediterranean diet is associated with better quality of life: data from the Osteoarthritis Initiative

Veronese

Stubbs

Noale

et al. 2016

The American Journal of Clinical Nutrition

129

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Background: The Mediterranean diet has positively influenced various medical conditions, but only a paucity of studies has considered the relation between the Mediterranean diet and quality of life (QOL) among people living in North America. Objective: We investigated whether a higher adherence to the Mediterranean diet (aMED) was associated with better QOL and decreased pain, stiffness, disability, and depression in a large cohort of North Americans from the Osteoarthritis Initiative. Results: Of the 4470 participants (2605 women; mean age: 61.3 y), those with a higher aMED had significantly more favorable scores on all outcomes investigated (P , 0.0001 for all comparisons). After adjustment for potential confounders in linear regression analyses, a higher aMED was significantly associated with a higher SF-12 physical composite scale value (b: 0.10; 95% CI: 0.05, 0.15; P , 0.0001), lower WOMAC scores (except for stiffness), and lower 95% CI: 20.09, 20.01; P = 0.01). An adjusted logistic regression analysis, taking as reference those in the 2 highest quintiles of the aMED score, confirmed these findings. Conclusion: Higher aMED is associated with better QOL and decreased pain, disability, and depressive symptoms. This trial was registered at clinicaltrials.gov as NCT00080171.Am J Clin Nutr 2016;104:1403-9.

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The Effect of the Mediterranean Diet on Hypertension: A Systematic Review and Meta-Analysis

Cited by 123 publications

References 28 publications

A Mediterranean diet lowers blood pressure and improves endothelial function: results from the MedLey randomized intervention trial ,

A Mediterranean diet lowers blood pressure and improves endothelial function: results from the MedLey randomized intervention trial ,

Adherence to a Mediterranean diet is associated with lower prevalence of osteoarthritis: Data from the osteoarthritis initiative

Adherence to the Mediterranean diet is associated with better quality of life: data from the Osteoarthritis Initiative

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