The effect of the macrophage migration inhibitory factor (MIF) on excisional wound healing <i>in vivo</i>

Kim, Bong-Sung; Breuer, Benjamin; Arnke, Kevin; Ruhl, Tim; Hofer, Tanja; Simons, David; Knobe, Matthias; Ganse, Bergita; Guidi, Marco Enrico Luigi; Beier, Justus P.; Fuchs, Paul Christian; Pallua, Norbert; Bernhagen, Jürgen; Grieb, Gerrit

doi:10.1080/2000656x.2019.1710710

Cited by 10 publications

(7 citation statements)

References 29 publications

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“… 69 , 70 When compared with TCP, Q-peptide uniquely upregulated MIF , which has been known to either promote fibroblast and keratinocyte migration for improved healing, or to reduce fibroblast migration while increasing inflammatory cytokine release and healing time, depending on the timing and degree of its expression. 34 , 71 …”

Section: Discussionmentioning

confidence: 99%

Angiopoietin-1 derived peptide hydrogel promotes molecular hallmarks of regeneration and wound healing in dermal fibroblasts

Vizely¹,

Wagner²,

Mandla³

et al. 2023

iScience

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Section: Discussionmentioning

confidence: 99%

Angiopoietin-1 derived peptide hydrogel promotes molecular hallmarks of regeneration and wound healing in dermal fibroblasts

Vizely¹,

Wagner²,

Mandla³

et al. 2023

iScience

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“…The MIF cytokine family exerts a special role in infectious diseases and inflammations (see Table 1). Aside from its role in infectious diseases, MIF plays a role in inflammatory diseases such as asthma or atherosclerosis, various forms of cancer, several autoimmune diseases, burn injuries, wound healing, and even free-flap ischemia [43][44][45][46][47][48][49][50][51][52][53][54][55][56][57]. The diverse functions of the MIF protein in the immune response of the organism to microbial pathogens have been demonstrated in various studies [37,39,41,58,59].…”

Section: Sepsis Is a Life-threatening Complication Of An Infection Th...mentioning

confidence: 99%

The Role of Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (D-DT/MIF-2) in Infections: A Clinical Perspective

Breidung,

Megas,

Freytag

et al. 2023

Biomedicines

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Macrophage migration inhibitory factor (MIF) and its homolog, D-dopachrome tautomerase (D-DT), are cytokines that play critical roles in the immune response to various infectious diseases. This review provides an overview of the complex involvement of MIF and D-DT in bacterial, viral, fungal, and parasitic infections. The role of MIF in different types of infections is controversial, as it has either a protective function or a host damage-enhancing function depending on the pathogen. Depending on the specific role of MIF, different therapeutic options for MIF-targeting drugs arise. Human MIF-neutralizing antibodies, anti-parasite MIF antibodies, small molecule MIF inhibitors or MIF-blocking peptides, as well as the administration of exogenous MIF or MIF activity-augmenting small molecules have potential therapeutic applications and need to be further explored in the future. In addition, MIF has been shown to be a potential biomarker and therapeutic target in sepsis. Further research is needed to unravel the complexity of MIF and D-DT in infectious diseases and to develop personalized therapeutic approaches targeting these cytokines. Overall, a comprehensive understanding of the role of MIF and D-DT in infections could lead to new strategies for the diagnosis, treatment, and management of infectious diseases.

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“…Promotes the production of pro-inflammatory molecules: TNF, IFN-γ, IL-1β, IL-2, IL-6, IL-8, NO, COX2, prostaglandins. Affects cell migration by interacting with chemokine receptors CXCR2 and CXCR4 [43,44].…”

Section: Macrophage мIgration іNhibitory Factor Mifmentioning

confidence: 99%

The clinical effectiveness of cryopreserved human amniotic membrane in diabetic foot syndrome

Ustymenko¹,

Nemtinov²,

Bolgarska³

et al. 2021

COT

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Diabetic foot syndrome with long-term unhealed wounds is the most common complication and cause of limb amputation in diabetes. The search for effective therapeutic agents and their inclusion in treatment protocols is a priority due to the increase in the number of cases of this socially significant disease and disability among the working population every year. The aim of the study is to evaluate the effectiveness of cryopreserved human amniotic membrane in the treatment of long-term non-healing wounds of the lower extremities in diabetic foot syndrome. Materials and methods. The pilot clinical study described 4 clinical cases of treatment of patients with diabetes mellitus type I and II (1 woman and 3 men aged 52 to 68 years) with long-term unhealed wounds of the limbs under standard therapy. After previous wound sanation the applications of the cryopreserved human amniotic membrane were performed. Once a week after the application, the dynamics of wound healing was assessed. Blood glucose levels were determined before amniotic membrane treatment and two hours after the procedure. Results. As a results of weekly applications of human amniotic membrane there was a gradual decrease in the area of the wound from the original size and increase the rate of healing. Thus, at the time of the second visit (after 7 days) the reduction in the area of the ulcer from the initial size in patient 1 was 33 %, patient 2 – 25 %, patient 3 – 33 % on the sole and patient 4 – 3 %, and the healing rate – 4.7 %, 3.6 %, 4.7 % and 0.43 % per day, respectively. The use of human amniotic membrane did not affect blood glucose levels when comparing values before application and two hours after the procedure. Regular follow-up visits of patients 3, 6, 9 and 12 months after the start of the study showed no recurrence of ulcers. Conclusions. It has been shown that the use of cryopreserved human amniotic membrane in patients with diabetes mellitus and diabetic foot syndrome with long-term unhealed wounds results in complete healing of ulcers with stable remission during the year of observation.

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The effect of the macrophage migration inhibitory factor (MIF) on excisional wound healing in vivo

Cited by 10 publications

References 29 publications

Angiopoietin-1 derived peptide hydrogel promotes molecular hallmarks of regeneration and wound healing in dermal fibroblasts

Angiopoietin-1 derived peptide hydrogel promotes molecular hallmarks of regeneration and wound healing in dermal fibroblasts

The Role of Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (D-DT/MIF-2) in Infections: A Clinical Perspective

The clinical effectiveness of cryopreserved human amniotic membrane in diabetic foot syndrome

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