The Effect of the Local and Oral Administration of Cod Liver Oil on the Rate of Wound Healing in Vitamin a-Deficient and Normal Rats*

Brandaleone, Harold; Papper, E. M.

doi:10.1097/00000658-194110000-00020

Cited by 33 publications

(5 citation statements)

References 1 publication

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“…Tretinoin (all‐trans‐retinoic acid), a derivative of vitamin A (retinol), has been used as a keratolytic agent in the topical treatment of acne 40 as well as a number of other keratinizing disorders 41 . Vitamin A has been linked with wound healing for over 50 years 42–47 . Recently, pretreatment with tretinoin cream has been shown clinically to accelerate the reepithelialization of dermabrasion wounds in man 48 and partial‐thickness 49 and full‐thickness 50 wounds in animals.…”

Section: Discussionmentioning

confidence: 99%

The Role of Topical Agents in the Healing of Full‐Thickness Wounds

Watcher

Wheeland

1989

The Journal of Dermatologic Surgery and Oncology

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Eight topical agents in current use were studied for their effects on wound contraction and rate of reepithelialization of full-thickness excisions using a porcine animal model. The following agents were applied daily for a period of 27 days: scarlet red ointment, benzoyl peroxide lotion, bacitracin ointment, silver sulfadiazine cream, aloe vera gel, tretinoin cream, capsaicin cream, and mupirocin ointment. The rate of reepithelialization was significantly enhanced by treatment with capsaicin, bacitracin, silver sulfadiazine, and scarlet red, and was markedly retarded by treatment with tretinoin. Wound contraction was significantly retarded by mupirocin, bacitracin, and silver sulfadizine. Knowledge of the effects of topical agents on various aspects of healing allows the clinician to choose the most appropriate material to use in a given clinical situation to optimize the healing process and produce the best final result.

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Section: Discussionmentioning

confidence: 99%

The Role of Topical Agents in the Healing of Full‐Thickness Wounds

Watcher

Wheeland

1989

The Journal of Dermatologic Surgery and Oncology

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“…Retinol deficiency can lead to a general impairment of wound healing, characterised by delayed epithelialisation [ 97 ], and can lead to abnormal epithelial keratinisation [ 99 ]. This has been proven in a rat model [ 118 ]. Steroids are known to contribute to wound healing delay.…”

Section: Natural and Semi-synthetic Compounds For Wound Healingmentioning

confidence: 92%

Antibiotics-Free Compounds for Chronic Wound Healing

2022

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The rapid rise in the health burden associated with chronic wounds is of great concern to policymakers, academia, and industry. This could be attributed to the devastating implications of this condition, and specifically, chronic wounds which have been linked to invasive microbial infections affecting patients’ quality of life. Unfortunately, antibiotics are not always helpful due to their poor penetration of bacterial biofilms and the emergence of antimicrobial resistance. Hence, there is an urgent need to explore antibiotics-free compounds/formulations with proven or potential antimicrobial, anti-inflammatory, antioxidant, and wound healing efficacy. The mechanism of antibiotics-free compounds is thought to include the disruption of the bacteria cell structure, preventing cell division, membrane porins, motility, and the formation of a biofilm. Furthermore, some of these compounds foster tissue regeneration by modulating growth factor expression. In this review article, the focus is placed on a number of non-antibiotic compounds possessing some of the aforementioned pharmacological and physiological activities. Specific interest is given to Aloe vera, curcumin, cinnamaldehyde, polyhexanide, retinoids, ascorbate, tocochromanols, and chitosan. These compounds (when alone or in formulation with other biologically active molecules) could be a dependable alternative in the management or prevention of chronic wounds.

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“…Besides the mentioned GFs, several small and large signaling molecules such as retinoic acid (vitamin-A), ascorbic acid (vitamin-C), vitamin-E, vitamin-K, hepatocyte growth factor, homeobox genes (HOX), hormones such as acetylcholine, and polyunsaturated fatty acids and their derivatives have also been observed. Moreover, they have been studied to have an effect in wound healing processes involving promotion of epithelial cell differentiation, collagen synthesis, immune function, biological membranes, and angiogenesis. ,− Likewise, the presence of zinc (Zn), copper (Cu), oxygen (O), and iron (Fe) has also been indicated in wound healing, which includes collagen synthesis and remodeling, re-epithelialization, angiogenesis, enzyme synthesis, and bactericidal function. − Despite our deep understanding of these well-known factors, successful regeneration of completely functional tissue without scar tissue formation remains elusive.…”

Section: Skin Tissue-anatomy Physiology and Healingmentioning

confidence: 99%

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

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Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling. These four steps significantly overlap with each other and are aided by various factors such as cells, cytokines (both anti- and pro-inflammatory), and growth factors that aid in the neo-tissue formation. In all these stages, advanced biomaterials provide several functional advantages, such as removing wound exudates, providing cover, transporting oxygen to the wound site, and preventing infection from microbes. In addition, advanced biomaterials serve as vehicles to carry proteins/drug molecules/growth factors and/or antimicrobial agents to the target wound site. In this review, we report recent advancements in biomaterials-based regenerative strategies that augment the skin tissue wound healing process. In conjunction with other medical sciences, designing nanoengineered biomaterials is gaining significant attention for providing numerous functionalities to trigger wound repair. In this regard, we highlight the advent of nanomaterial-based constructs for wound healing, especially those that are being evaluated in clinical settings. Herein, we also emphasize the competence and versatility of the three-dimensional (3D) bioprinting technique for advanced wound management. Finally, we discuss the challenges and clinical perspective of various biomaterial-based wound dressings, along with prospective future directions. With regenerative strategies that utilize a cocktail of cell sources, antimicrobial agents, drugs, and/or growth factors, it is expected that significant patient-specific strategies will be developed in the near future, resulting in complete wound healing with no scar tissue formation.

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The Effect of the Local and Oral Administration of Cod Liver Oil on the Rate of Wound Healing in Vitamin a-Deficient and Normal Rats*

Cited by 33 publications

References 1 publication

The Role of Topical Agents in the Healing of Full‐Thickness Wounds

The Role of Topical Agents in the Healing of Full‐Thickness Wounds

Antibiotics-Free Compounds for Chronic Wound Healing

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

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