The Effect of the Level of Dietary Calcium and Magnesium on the Digestibility of Fatty Acids, Simple Triglycerides, and Some Natural and Hydrogenated Fats ,  ,

Cheng, Amber L. S.; Morehouse, Margaret G.; Deuel, Harry J.

doi:10.1093/jn/37.2.237

Cited by 91 publications

(30 citation statements)

References 15 publications

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“…Loss of calcium and of fat in the stools has been shown to be interrelated (7,14,32). Not only are high fat intakes associated with decreased calcium absorption rates from the gut, but also high calcium intakes may lead to reduced fat absorption.…”

Section: Discussionmentioning

confidence: 99%

Growth and Mineral Metabolism in Very Low Birth Weight Infants. II. Effects of Calcium Supplementation on Growth and Divalent Cations

et al. 1975

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Section: Discussionmentioning

confidence: 99%

Growth and Mineral Metabolism in Very Low Birth Weight Infants. II. Effects of Calcium Supplementation on Growth and Divalent Cations

et al. 1975

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“…Less phosphate in the colon means less buffering of the acidproducing fermentation of fibre and a lower colonic pH. Longchain saturated fatty acids bind calcium more strongly than longchain unsaturated fatty acids (Cheng et al, 1949). A lower colonic pH results in less formation of DC from CA, while the activity of the bacterial enzyme 7a-dehydroxylase is inhibited in vitro at pHo6 (MacDonald et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

Serum bile acids and risk factors for colorectal cancer

2004

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The ratio of deoxycholic acid to chenodeoxycholic acid in the serum of 62 men was inversely related to body mass index and to saturated fat intake after adjustment for body mass index, smoking, and age conversely, this ratio was associated positively with the intake of fibre from grains. Bile acids (BA) are potential risk factors for colorectal cancer (CRC). A small prospective study suggests that a high ratio of deoxycholic acid (DC) to cholic acid (CA) in serum is associated with an increased incidence of CRC (Costarelli et al, 2002). Based on a complete model of BA metabolism (Chaplin, 1998), it can be argued that the ratio of unconjugated DC to unconjugated chenodeoxycholic acid (CDC) in serum, in short the DC/CDC ratio, is relevant to CRC. Unconjugated DC in serum is regarded as being a biomarker for habitual colonic exposure to the cancerpromoting DC (Bayerdörffer et al, 1993), because the unconjugated BA is absorbed in the colon. The DC/CDC ratio may be a marker with high intraindividual reproducibility, because the colonic absorption of unconjugated DC is nearly equal to that of unconjugated CDC (Mekhjian et al, 1979) and the hepatic clearance of DC from the portal vein is equal to that of CDC (Ahlberg et al, 1977). The only difference between the variation of DC and that of CDC can be attributed to the dehydroxylation of the primary bile acid cholic acid (CA) to the secondary bile acid DC. The formation of CA, unlike that of CDC, is regulated by the amount of BA returning to the liver. If less unconjugated DC is returned, relatively more CA will be formed and the DC/CDC ratio in serum will be higher.We studied the relation between the DC/CDC ratio in serum and such CRC-promoting (dietary) factors as intake of energy, saturated fat, fibre, calcium, smoking and body mass index (Giovannucci, 2003). MATERIALS AND METHODSNonfasting blood specimens were collected from 121 men and women in the range of 20 -60 years old, who participated in the validation study of the Dutch food frequency questionnaire for the European Prospective Investigation into Cancer and Nutrition (EPIC) . The samples of the 62 men, from which the blood was drawn more than 4 h after a meal, were selected for analysis of individual BA in the serum, as described before (Salemans et al, 1993). Only men were selected for logistic reasons. RESULTSThe characteristics of the study subjects, the dietary intakes of nutrients and the concentrations of total unconjugated BA in serum are shown in Table 1. Dietary fibre from sources other than fruits and vegetables was derived mainly from grains. In all, 25% of the men were current smokers.Saturated fat intake was inversely related to the log of serum DC/ CDC ratio univariately, as well as after adjustment for potential confounding factors like body mass index, smoking age and (Table 2). Also, calcium intake was inversely associated to the log of serum DC/CDC ratio in univariate analyses, but disappeared in the adjusted models. Conversely, for total dietary fibre, a positive relation was observed in t...

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“…Digestion of fat was significantly higher for pigs fed diets with added fat as compared with those fed the basal diet Deuel and Hallman, 1940;Crockett and Deuel, 1947;Cheng et al, 1949;and Karvinen et al, 1957). However, Hoagland andSnider (1943a, 1943b) postulated that factors other than melt ing point determined the relative digestibility of fats.…”

Section: Resultsmentioning

confidence: 99%

“…With the increase in fat excretion there was also a corresponding decrease in absorption of the triglycerides. Crockett and Deuel (1947), Cheng et al (1949) and Karvinen et al (1957) have also reported a decrease in digestibility of fat sources as their melting point increased. On the other hand, Hoagland and Snider (1943a) believed some factor other than melting point determined the relative digestibility of fats since they observed a higher digestibility coefficient for fats contain ing long chain fatty acids.…”

Section: Molecular Weight Of Pat Sourcementioning

confidence: 98%

Fat utilization by the young pig

Frobish

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The Effect of the Level of Dietary Calcium and Magnesium on the Digestibility of Fatty Acids, Simple Triglycerides, and Some Natural and Hydrogenated Fats , ,

Cited by 91 publications

References 15 publications

Growth and Mineral Metabolism in Very Low Birth Weight Infants. II. Effects of Calcium Supplementation on Growth and Divalent Cations

Growth and Mineral Metabolism in Very Low Birth Weight Infants. II. Effects of Calcium Supplementation on Growth and Divalent Cations

Serum bile acids and risk factors for colorectal cancer

Fat utilization by the young pig

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