The effect of the initiation of renal replacement therapy on lipid profile and oxidative stress during the first 6 months of treatment

Diepeveen, S. H. A.; Verhoeven, Gertie H.W.E.; Palen, Job van der; Dikkeschei, Bert L.D.; Tits, Berry L.J. van; Kolsters, G.; Offerman, Jjg; Bilo, Henk J. G.; Stalenhoef, Anton F. H.

doi:10.1016/j.cccn.2005.05.007

Cited by 8 publications

(9 citation statements)

References 36 publications

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“…Longer dialysis duration as well as higher BMI in the nonsmokers might explain this difference in the lipogram and this corresponds with the report of Dejanova (2001) [40] as well as Odamaki (1999) [41] and their co-workers. Further, as we have noticed the dialysis process itself resulted in disturbed lipid profile and this was as well noted by other investigators [42][43][44]. However, Kalantar-Zadeh and co-workers reported equal prevalence of dyslipidaemia in HD and non-dialysis morbid populations [45] possibly because their patients came from different geographic area but also because they have different genetic backgrounds as 31% were African Americans and 52% Hispanics.…”

Section: Discussionsupporting

confidence: 53%

The impact of haemodialysis-associated variables on lipid profile in Egyptian haemodialysis population

et al. 2007

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Section: Discussionsupporting

confidence: 53%

The impact of haemodialysis-associated variables on lipid profile in Egyptian haemodialysis population

et al. 2007

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“…Concerning AGEs, we focused our attention on GA. As for other AGEs, we expected to observe that GA levels were over the ranges of normality not only in DM CKD-G5D group but also in non-DM CKD-G5D patients, due to the increased oxidative stress and the reduced kidney clearance typical of the disease [15, 17, 18, 50]. Of course, the upregulation of sRAGE at levels above controls in both groups and its further increase in DM seem to suggest the existence of a glycated milieu in all CKD-G5D patients, regardless of the presence of DM.…”

Section: Discussionmentioning

confidence: 99%

Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation

Dozio

Corradi

Vianello

et al. 2017

Mediators of Inflammation

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Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients. The levels of sRAGE, cFGF-23, BNP, and proinflammatory markers were over the ranges of normality in both DM and non-DM groups. Only GA and sRAGE levels were increased in DM compared to non-DM patients. Plasma levels of sRAGE and CRP were the only independent predictors of BNP concentration. In conclusion, in DM CKD-G5D patients, sRAGE appeared to be a marker of cardiac remodeling. Indeed, its increase could be a potential protective mechanism against the increased risk of cardiovascular complications related to AGEs and inflammation. The causal relationship between sRAGE and cardiovascular risk in these patients needs to be further confirmed by mechanistic studies.

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“…Oxidative stress has been implicated in endothelial dysfunction and it also contributes to the high risk for cardiovascular disease (CVD), through the development of endothelial injury and acceleration of atherosclerosis in chronic kidney disease patients 1 . Oxidative stress is enhanced in dialysis patients possibly due to a decrease in the antioxidant reserve and an increase in the synthesis of reactive oxygen species (ROS) 2,3 . End‐stage renal disease (ESRD) patients are in a state of chronic oxidative stress, with excessive ROS production (e.g., O 2 , H 2 O 2 , and OH − ) 4,5 .…”

Section: Introductionmentioning

confidence: 99%

“…1 Oxidative stress is enhanced in dialysis patients possibly due to a decrease in the antioxidant reserve and an increase in the synthesis of reactive oxygen species (ROS). 2,3 End-stage renal disease (ESRD) patients are in a state of chronic oxidative stress, with excessive ROS production (e.g., O 2 , H 2 O 2 , and OH À ). 4,5 This is commonly attributed to the recurrent activation of polymorphonuclear neutrophils (PMN) and monocytes in contact with bioincompatible membranes, and/or endotoxins transferred from the dialysate.…”

Section: Introductionmentioning

confidence: 99%

Effect of phosphate binders on oxidative stress and inflammation markers in hemodialysis patients

Peres

Dalboni

Canziani

et al. 2009

Hemodialysis International

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It has been suggested that phosphate binders may reduce the inflammatory state of hemodialysis (HD) patients. However, it is not clear whether it has any effect on oxidative stress. The objective of this study was to evaluate the effect of sevelamer hydrochloride (SH) and calcium acetate (CA) on oxidative stress and inflammation markers in HD patients. Hemodialysis patients were randomly assigned to therapy with SH (n=17) or CA (n=14) for 1 year. Before the initiation of therapy (baseline) and at 12 months, we measured in vitro reactive oxygen species (ROS) production by stimulated and unstimulated polymorphonuclear neutrophils and serum levels of tumor necrosis factor alpha, interleukin-10, C-reactive protein, and albumin. There was a significant reduction of spontaneous ROS production in both groups after 12 months of therapy. There was a significant decrease of Staphylococcus aureus stimulated ROS production in the SH group. There was a significant increase in albumin serum levels only in the SH group. In the SH group, there was also a decrease in the serum levels of tumor necrosis factor alpha and C-reactive protein. Our results suggest that compared with CA treatment, SH may lead to a reduction in oxidative stress and inflammation. Therefore, it is possible that phosphate binders exert pleiotropic effects on oxidative stress and inflammation, which could contribute toward decreasing endothelial injury in patients in HD.

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The effect of the initiation of renal replacement therapy on lipid profile and oxidative stress during the first 6 months of treatment

Cited by 8 publications

References 36 publications

The impact of haemodialysis-associated variables on lipid profile in Egyptian haemodialysis population

The impact of haemodialysis-associated variables on lipid profile in Egyptian haemodialysis population

Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation

Effect of phosphate binders on oxidative stress and inflammation markers in hemodialysis patients

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