The effect of the high-fat diet supplemented with various forms of chromium on rats body composition, liver metabolism and organ histology Cr in liver metabolism and histology of selected organs

Ognik, Katarzyna; Dworzański, Wojciech; Sembratowicz, Iwona; Fotschki, Bartosz; Cholewińska, Ewelina; Listos, Piotr; Juśkiewicz, Jerzy

doi:10.1016/j.jtemb.2020.126705

Cited by 14 publications

(22 citation statements)

References 59 publications

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“… A Cr intake from diet calculated from feed intake data presented in Ognik et al [ 26 ] Feed intake: diet: standard—17.45 g/day, high-fat—16.17 g/day; Cr form: none—19.9 g/day, Cr-Pic—16.8 g/day, Cr-Met—16.8 g/day, Cr-NP—16.7 g/day [ 26 ] B Total Cr intake from diet and water (Cr concentration in water administered to rats 2.9 µg/L) a,b,c,d Mean values within a row with unlike superscript letters were shown to be significantly different ( P <0.05) …”

Section: Resultsmentioning

confidence: 99%

“…Feed intake: diet: standard—17.45 g/day, high-fat—16.17 g/day; Cr form: none—19.9 g/day, Cr-Pic—16.8 g/day, Cr-Met—16.8 g/day, Cr-NP—16.7 g/day [ 26 ]…”

Section: Resultsmentioning

confidence: 99%

“…The use of high-fat diet, especially for a long time, leads to impairment of carbohydrate and lipid metabolism and to obesity. Rats fed a HFD had higher body weight than rats fed a standard diet despite lower feed intake [ 26 ]. Obesity in rats fed a HFD may be due to the higher caloric value of the diet as well as to increased concentrations of leptin and reduced concentrations of ghrelin, as noted in our study.…”

Section: Discussionmentioning

confidence: 99%

“…The present study is part of a larger experiment. Experimental design and other physiological results have been published in Ognik et al [ 26 ], Dworzański et al [ 27 ] and Dworzański et al [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

“…The leptin level in the plasma of rats receiving a diet with the addition of Cr-Pic or Cr-Met was higher than in rats receiving a diet without added Cr or with the addition Table 2 Chromium excretion patterns in the digestibility and retention test A Cr intake from diet calculated from feed intake data presented in Ognik et al [26] Feed intake: diet: standard-17.45 g/day, high-fat-16.17 g/day; Cr form: none-19.9 g/day, Cr-Pic-16.8 g/day, Cr-Met-16.8 g/day, Cr-NP-16.7 g/day [26] B Total Cr intake from diet and water (Cr concentration in water administered to rats 2.9 µg/L) of Cr-NP (P < 0.001). In the plasma of rats receiving Cr-Pic, the insulin level was higher (P = 0.034) and the noradrenalin level was lower (P = 0.009) than in the rats from the other groups.…”

Section: Effect Of Form Of Crmentioning

confidence: 99%

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Effect of a high-fat diet and chromium on hormones level and Cr retention in rats

Stępniowska

Tutaj

Juśkiewicz

et al. 2021

J Endocrinol Invest

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Aims The aim of the study was to determine how the administration of a high-fat diet supplemented with various forms of chromium to rats affects accumulation of this element in the tissues and levels of leptin, ghrelin, insulin, glucagon, serotonin, noradrenaline and histamine, as well as selected mineral elements. Methods The experiment was conducted on 56 male Wistar rats, which were divided into 8 experimental groups. The rats received standard diet or high fat diet (HFD) with addition of 0.3 mg/kg body weight of chromium(III) picolinate (Cr-Pic), chromium(III)-methioninate (Cr-Met), or chromium nanoparticles (Cr-NP). Results Chromium in organic forms was found to be better retained in the body of rats than Cr in nanoparticles form. However, Cr-Pic was the only form that increased the insulin level, which indicates its beneficial effect on carbohydrate metabolism. In blood plasma of rats fed a high-fat diet noted an increased level of serotonin and a reduced level of noradrenaline. The addition of Cr to the diet, irrespective of its form, also increased the serotonin level, which should be considered a beneficial effect. Rats fed a high-fat diet had an unfavourable reduction in the plasma concentrations of Ca, P, Mg and Zn. The reduction of P in the plasma induced by supplementation with Cr in the form of Cr-Pic or Cr-NP may exacerbate the adverse effect of a high-fat diet on the level of this element. Conclusion A high-fat diet was shown to negatively affect the level of hormones regulating carbohydrate metabolism (increasing leptin levels and decreasing levels of ghrelin and insulin).

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Section: Resultsmentioning

confidence: 99%

“…Feed intake: diet: standard—17.45 g/day, high-fat—16.17 g/day; Cr form: none—19.9 g/day, Cr-Pic—16.8 g/day, Cr-Met—16.8 g/day, Cr-NP—16.7 g/day [ 26 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Effect Of Form Of Crmentioning

confidence: 99%

See 3 more Smart Citations

Effect of a high-fat diet and chromium on hormones level and Cr retention in rats

Stępniowska

Tutaj

Juśkiewicz

et al. 2021

J Endocrinol Invest

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Acute, subacute, and sub‐chronic toxicity evaluation of Bletilla formosana tubers in rats

Wang,

Zhang,

Zhao

et al. 2024

Food Safety and Health

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Bletilla formosana (Hayata) Schltr. is an important economic medicinal and edible plant in China. Its tubers (BFTs) are traditionally consumed as a beverage and canned foods for promoting human health. In this paper, the nutrients, the contents of total phenol, flavonoids, and polysaccharides, and the safety and toxicity of BFT are determined. The chemical analysis reported that BFT is rich in proteins, polysaccharides, polyphenols, flavonoids, and trace elements. The acute (14 days), subacute (28 days), and sub‐chronic (90 days) toxicities of BFT were evaluated for the first time in female and male rats. An acute toxicity study showed that the female rats by single oral administrations of BFT with 10,000 mg/kg body weight (BW) did not have behavioral changes and mortality, indicating that 50% lethal dose (LD50) of BFT was over 10,000 mg/kg BW. Similarly, BFT at 5000 mg/kg BW for consecutive 28 and 90 days in rats was also not toxic for rats after the analysis of physiological and biochemical parameters. Additionally, there are no significant differences on the histopathological changes of the heart, liver, spleen, lung, kidney, ovary, or testis between the control and BFT groups. Our findings revealed that BFT with concentration of less than 5000 mg/kg BW are safe for the female or male rats, indicating that BFT could be regarded as a safe food source.

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Response of microbial community structure to chromium contamination in Panax ginseng-growing soil

Sun

Jin

et al. 2022

Environ Sci Pollut Res

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The effect of the high-fat diet supplemented with various forms of chromium on rats body composition, liver metabolism and organ histology Cr in liver metabolism and histology of selected organs

Cited by 14 publications

References 59 publications

Effect of a high-fat diet and chromium on hormones level and Cr retention in rats

Effect of a high-fat diet and chromium on hormones level and Cr retention in rats

Acute, subacute, and sub‐chronic toxicity evaluation of Bletilla formosana tubers in rats

Response of microbial community structure to chromium contamination in Panax ginseng-growing soil

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