The effect of the endotoxemia on the abomasal emptying rate in suckling lambs as shown by acetaminophen absorption test

Mozaffari, Ali Asghar; Jarakanibayat, S.; Vosough, Darioush; Eskandarzade, Neda; Tajic, J.

doi:10.1007/s00580-017-2585-1

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…For each timepoint where cytokine values fell below the LLOD, the timepoint was assigned the

. 27 If greater than 50% of a treatment's cytokine values were below the LLOD, that cytokine was deemed unsuitable for statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

“…The lower limit of detection (LLOD) for IL‐1 beta was 4.2 pg/mL, for IL‐6 was 7.85 pg/mL, for IL‐8 was 55.92 pg/mL, for IL‐10 was 19.64 pg/mL, and for TNF‐α was 3.88 pg/mL. For each timepoint where cytokine values fell below the LLOD, the timepoint was assigned the

\frac{LLOD}{\sqrt{2}}

27 . If greater than 50% of a treatment's cytokine values were below the LLOD, that cytokine was deemed unsuitable for statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

“…A-C Significant change in heart rate from the time of drug administration for pairwise comparisons between treatments; P < .05 administration of endotoxin might alter acetaminophen pharmacokinetics in horses. 16 The effect of endotoxin administration on acetaminophen absorption kinetics has been reported in lambs 27 and humans 28 where there was a significant increase in T max and decrease in C max and AUC for endotoxemic individuals when compared to healthy individuals. These studies suggested that the decreased absorption of acetaminophen in endotoxemic individuals could be because of a decrease in abomasal or gastric emptying rate, the rate limiting step in acetaminophen absorption.…”

Section: Time (Hr)mentioning

confidence: 99%

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Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia

Mercer

Davis

McKenzie

et al. 2023

Veterinary Internal Medicne

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Background Acetaminophen has been evaluated in horses for treatment of musculoskeletal pain but not as an antipyretic. Objectives To determine the pharmacokinetics and efficacy of acetaminophen compared to placebo and flunixin meglumine in adult horses with experimentally induced endotoxemia. Animals Eight university owned research horses with experimentally induced endotoxemia. Methods Randomized placebo controlled crossover study. Horses were treated with acetaminophen (30 mg/kg PO; APAP), flunixin meglumine (1.1 mg/kg, PO; FLU), and placebo (PO; PLAC) 2 hours after administration of LPS. Plasma APAP was analyzed via LC‐MS/MS. Serial CBC, lactate, serum amyloid A, heart rate and rectal temperature were evaluated. Serum IL‐1β, IL‐6, IL‐8, IL‐10, and TNF‐α were evaluated by an equine‐specific multiplex assay. Results Mean maximum plasma APAP concentration was 13.97 ± 2.74 μg/mL within 0.6 ± 0.3 hour after administration. At 4 and 6 hours after treatment, both APAP ( P = <.001, P = .03, respectively) and FLU ( P = .0045 and P < .001, respectively) had a significantly greater decrease in rectal temperature compared to placebo. FLU caused greater heart rate reduction than APAP at 4 and 6 hours ( P = .004 and P = .04), and PLAC at 4 hours ( P = .05) after treatment. Conclusions and Clinical Importance The pharmacokinetics of acetaminophen in endotoxemic horses differ from those reported by previous studies in healthy horses. Acetaminophen is an option for antipyresis in clinical cases, particularly when administration of traditional NSAIDs is contraindicated.

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“…For each timepoint where cytokine values fell below the LLOD, the timepoint was assigned the

. 27 If greater than 50% of a treatment's cytokine values were below the LLOD, that cytokine was deemed unsuitable for statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

\frac{LLOD}{\sqrt{2}}

27 . If greater than 50% of a treatment's cytokine values were below the LLOD, that cytokine was deemed unsuitable for statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

Section: Time (Hr)mentioning

confidence: 99%

See 1 more Smart Citation

Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia

Mercer

Davis

McKenzie

et al. 2023

Veterinary Internal Medicne

View full text Add to dashboard Cite

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Effect of erythromycin on abomasal emptying in suckling lambs with experimental endotoxemia

Shabbooie

Ghane

2022

Small Ruminant Research

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Watery mouth disease in neonatal lambs: a systematic literature review

Angell

Duncan

2020

Livestock

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Watery mouth disease is considered to be a significant cause of neonatal mortality in lambs. The clinical signs are strongly associated with an endotoxaemia produced as a result of the lysis of Gram-negative bacteria. It has been associated with mass antibiosis to neonatal lambs at birth, a practice which is now untenable. It can be prevented in many cases through the timely administration of good quality colostrum and a hygienic birth environment. However, despite this, much remains unknown about the specific aetiopathogenesis. Alternative strategies for prevention, treatment and control are required, particularly when colostrum quality is poor, or delivery is absent, and where unhygienic conditions predominate.

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The effect of the endotoxemia on the abomasal emptying rate in suckling lambs as shown by acetaminophen absorption test

Cited by 3 publications

References 11 publications

Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia

Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia

Effect of erythromycin on abomasal emptying in suckling lambs with experimental endotoxemia

Watery mouth disease in neonatal lambs: a systematic literature review

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