The Effect of the Endoscopic Duodenal-Jejunal Bypass Liner on Obesity and Type 2 Diabetes Mellitus, a Multicenter Randomized Controlled Trial

Koehestanie, Parweez; Jonge, Charlotte de; Berends, Frits J.; Janssen, Ignace; Bouvy, Nicole D.; Greve, Jan

doi:10.1097/sla.0000000000000794

Cited by 136 publications

(105 citation statements)

References 37 publications

(59 reference statements)

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“…Previous studies have shown that after extraction of DJBL, body weight partially increases and glucose control slightly deteriorates, but some of its effects still persist (de Jonge et al 2013b, Koehestanie et al 2014. Here, we show that 3 months after its removal, DJBL-associated body weight reduction was still present with an average regain of 3 kg from 12 kg that was lost.…”

Section: :1supporting

confidence: 59%

Endocrine effects of duodenal–jejunal exclusion in obese patients with type 2 diabetes mellitus

Kaválková

Mráz

Trachta

et al. 2016

Journal of Endocrinology

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Duodenal-jejunal bypass liner (DJBL) is an endoscopically implantable device designed to noninvasively mimic the effects of gastrointestinal bypass operations by excluding the duodenum and proximal jejunum from the contact with ingested food. The aim of our study was to assess the influence of DJBL on anthropometric parameters, glucose regulation, metabolic and hormonal profile in obese patients with type 2 diabetes mellitus (T2DM) and to characterize both the magnitude and the possible mechanisms of its effect. Thirty obese patients with poorly controlled T2DM underwent the implantation of DJBL and were assessed before and 1, 6 and 10 months after the implantation, and 3 months after the removal of DJBL. The implantation decreased body weight, and improved lipid levels and glucose regulation along with reduced glycemic variability. Serum concentrations of fibroblast growth factor 19 (FGF19) and bile acids markedly increased together with a tendency to restoration of postprandial peak of GLP1. White blood cell count slightly increased and red blood cell count decreased throughout the DJBL implantation period along with decreased ferritin, iron and vitamin B12 concentrations. Blood count returned to baseline values 3 months after DJBL removal. Decreased body weight and improved glucose control persisted with only slight deterioration 3 months after DJBL removal while the effect on lipids was lost. We conclude that the implantation of DJBL induced a sustained reduction in body weight and improvement in regulation of lipid and glucose. The increase in FGF19 and bile acids levels could be at least partially responsible for these effects.

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Section: :1supporting

confidence: 59%

Endocrine effects of duodenal–jejunal exclusion in obese patients with type 2 diabetes mellitus

Kaválková

Mráz

Trachta

et al. 2016

Journal of Endocrinology

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“…Sixty-eight studies were used to calculate adverse events and early removal rates, 10 45,79 For the EndoBarrier DJBS meta-analyses, 11 studies met inclusion criteria. [92][93][94][95][96][97][98][99][100][101][102] Of these, 9 reported adverse events and early removal rates, 92-97,99-101 3 reported %EWL at 12 months, 97,100,101 4 were RCTs that reported %EWL over a sham or control group at device removal, 92,94,95,100 9 reported changes in glycosylated hemoglobin (HgA 1c ), 92,93,[95][96][97][98][99][100]102 and 3 reported changes in HgA 1c over a sham or control group in RCTs. 93,95,100 %EWL at 12 months and mean difference in %EWL over a control group for primary EBTs Orbera IGB.…”

Section: Search Resultsmentioning

confidence: 96%

ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies

Dayyeh¹,

Kumar²,

Edmundowicz³

et al. 2015

Gastrointestinal Endoscopy

368

179

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“…The DJBL is comprised of a nitinol anchor, which is used to reversibly affix the device to the wall of the duodenal bulb [12][13][14][15]. Before reimplantation, all patients were examined with a gastroduodenoscopy to evaluate the state of the duodenal bulb, which was where the DJBL anchor was positioned.…”

Section: Anatomic Change In Duodenal Bulb Per-implantation and Postexmentioning

confidence: 99%

mentioning

confidence: 99%

Is reimplantation of the duodenal-jejunal bypass liner feasible?

Koehestanie

Betzel

Aarts

et al. 2015

Surgery for Obesity and Related Diseases

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The Effect of the Endoscopic Duodenal-Jejunal Bypass Liner on Obesity and Type 2 Diabetes Mellitus, a Multicenter Randomized Controlled Trial

Abstract: The DJBL is a safe and effective alternative to invasive bariatric procedures. Six months of DJBL treatment combined with diet leads to superior weight loss and improvement of T2DM when compared with diet alone.

Cited by 136 publications

References 37 publications

Endocrine effects of duodenal–jejunal exclusion in obese patients with type 2 diabetes mellitus

Endocrine effects of duodenal–jejunal exclusion in obese patients with type 2 diabetes mellitus

ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies

Is reimplantation of the duodenal-jejunal bypass liner feasible?

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