The effect of the drug “Bendamine” on the clinical and morphological parameters of dogs in heart failure

Varkholiak, I. S.; Gutyj, B. V.; Gufriy, D. F.; Сачук, Р. М.; Mylostyvyi, Roman; Radzikhovskyi, M.; Sedilo, H. M.; Izhboldina, Olena

doi:10.32718/ujvas4-3.13

Cited by 9 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Основною перевагою є вміст поживних речовин у натуральних продуктах. А до недоліків можна зарахувати трудомісткість щодо витрат часу та складність точно збалансувати раціони собак (Protopopova, 2016;Sobol, 2020;Varkholiak et al, 2021).…”

Section: вступunclassified

Organization of rationed feeding and feeding of dogs

Pivtorak,

Semchuk,

Naumyk

2023

SMLNUVMBA

View full text Add to dashboard Cite

In today's conditions, the issues of feeding, maintenance, upbringing, training, and prevention of infectious diseases were and are relevant in dog breeding. Many primarily foreign scientists conduct research in this field of science. However, scientists in Ukraine do not pay enough attention to the study and improvement of the technology for feeding and keeping dogs in kennels of departmental institutions, mainly where dogs are used to help people and serve. A dog is a man's best friend, reliable assistant, and faithful companion. Even in ancient times, a person tamed a dog and adapted it to perform various tasks. People use sled dogs to move over challenging terrain and transport various cargo. Guard dogs protect herds of livestock, protect them from predators, and protect critical economic facilities and human housing. Service dogs successfully serve on the border, help to detain criminals, search for drugs and explosive devices, perform the duties of signalmen and paramedics, rescue drowning people, and search for victims in the rubble after an earthquake and swept away by snow avalanches in the mountains. Hunting dogs of all breeds help hunters search for and catch wild animals or birds, making hunting interesting and exciting. The article assesses the technique of feeding dogs in the “Home of Rescued Animals” BF conditions. The reported data shows that the number and breed composition of dogs has been gradually increasing over the past year, and by the beginning of 2023, it will be 84 dogs. The basis of the diet for dogs is the food of animal origin (offal, meat, milk, and dairy products, animal fat), plant origin (oat groats, barley, millet, vegetables), sea fish or seafood, mineral additives (bone meal, table salt ), vitamin preparations (Tetravit, Catozal). In the conditions of the BF “Home of Rescued Animals”, dogs are fed twice a day – in the morning and the evening, approximately 1.5 hours before the walk and 30–60 minutes after the walk. Feeding dogs depends on the daily routine–drinking all dogs without restrictions. The blood test results prove that all physiological processes in the animal's body commonly occur without deviations. In current conditions, the basis of a dog's health, longevity, and good physical condition is a complete and balanced diet. The type of feeding should meet the needs of the dog's body and differ depending on the stage of the life cycle (young growth period, sexually mature dog, animal in the aging period) and the characteristics of physiological development (lack of various physical activities, increased physical activity, pregnancy and feeding puppies, etc.).

show abstract

Section: вступunclassified

Organization of rationed feeding and feeding of dogs

Pivtorak,

Semchuk,

Naumyk

2023

SMLNUVMBA

View full text Add to dashboard Cite

show abstract

“…Експеримент щодо визначення параметрів гострої токсичності препарату "БТФ плюс", за одноразового внутрішньошлункового введення, було проведено на 36 самках нелінійних білих щурів 3-4-місячного віку і масою 19 -200 г, що утримувались за оптимальних умов віварію (Kotsiumbas et al, 2006;Varkholiak & Gutyj, 2018;Varkholiak et al, 2021): температура у приміщенні складала 18 ±2 °C, відносна вологість повітря 60-70 %, цикл освітлення день-ніч упродовж експерименту складав10-14 год, а також було забезпечено 10-разову зміну об'єму повітря в кімнаті віварію за годину.…”

Section: матеріал і методи дослідженьunclassified

Experimental evaluation of the acute toxicity and irritant effect of “BTF plus” – a veterinary medicinal product for the normalization of metabolic processes in animals and poultry

Sachuk,

Gutyj,

Velesyk

et al. 2023

SMLNUVMBA

View full text Add to dashboard Cite

Laboratory studies were conducted to determine the acute toxicity of the veterinary drug “BTF plus” on white rats and white mice. The preparation “BTF plus” is a complex vitamin and mineral preparation, which is used to normalize and correct metabolic processes in poultry and animals. The drug is used for various types of animals and poultry as a stimulating, tonic and general strengthening agent for: obstetric pathologies (difficult births, postpartum complications, paresis, eclampsia, sexual cycle disorders); metabolic disorders caused by irrational feeding, malnutrition, asthenic syndrome, etc.; anemia with helminthiasis; secondary anemias, as an additional means in the treatment of magnesium and calcium deficiency; to increase muscle activity, with significant loads, overstrain and exhaustion in animals; to increase the body’s resistance to various pathogens; to stimulate growth, development and live weight gain in young animals; as an additional means in the treatment of diseases caused by various factors (infectious and non-infectious origin). Based on the results of determining the parameters of the acute toxicity of the drug “BTF plus” in the case of a single intragastric administration to white female rats, it was not possible to calculate the LD50, since the death of laboratory animals was not detected within 14 days after administration. At the same time, the maximum injected dose (based on the absolute weight of the drug) was 40000.0 mg/kg of body weight, which allows the drug to be classified as VI class of toxicity – the substances are relatively harmless (LD50 > 15000.0 mg/kg of body weight), and according to the degree of danger to IV class – low-hazardous substances (LD50 > 5000.0 mg/kg of body weight). Based on the results of determining the parameters of the acute toxicity of the drug “BTF plus” in the case of a single subcutaneous injection to white female rats and male mice, it was not possible to calculate the LD50, since the death of laboratory animals was not detected within 14 days after administration. At the same time, the maximum injected dose (based on the absolute weight of the drug) was 20000,0 and 40000.0 mg/kg of body weight for both species of animals, respectively, which allows it to be classified as VI class – relatively harmless substances (LD50Subcut > 4500 mg/kg of body weight). Further studies will be the next stage of pre-registration tests aimed at studying the embryotoxic effect of “BTF plus”, which is mandatory material of the “Safety and residue studies” section of the dossier for this drug.

show abstract

“…Лікарські речовини, які визначають фармакологічну активність нових препаратів відповідно до вимог нормативно-технічної документації, мають зараховуватися до класу високочистих. Наявність в них навіть незначної кількості домішок може призводити до небажаних наслідків (Zhungietu & Granik, 2000;Dajani et al, 2016;Gutyj et al, 2017;Varkholiak et al, 2021). Джерелами забруднення лікарської субстанції часто є недостатня очистка сировини і допоміжних матеріалів, які використовують у синтезі, а також відхилення від технологічних процесів або їхня недосконалість, що ведуть до утворення побічних продуктів (Todoriuk et al, 2018).…”

Section: вступunclassified

Dynamics of individual biochemical parameters of blood of intact white mice under the action of the drug “Vitosept”

et al. 2022

Self Cite

View full text Add to dashboard Cite

The active substance of the drug “Vitosept” is high-purity sodium hypochlorite (HPSH), obtained by the direct electrochemical reaction on a newly developed diaphragm-free flow cell, bypassing the formation of molecular chlorine. The developers (Altapharm, Dnipro) used an isotonic (0.9 %) sodium chloride solution prepared in water purified by special technology as the starting electrolyte. The study aimed to determine the effect of different concentrations of Vitosept on the dynamics of serum biochemical parameters of intact white mice. During our research, we found that intragastric administration of even the highest concentrations (500 mg/L) of the drug “Vitosept” did not cause the death of animals or visible signs of intoxication. According to the analysis of clinical manifestations, behavioral reactions, assessment of discomfort, reflex reactions, and the course of metabolic processes, the animals of the experimental groups did not differ from the analogs of the control group. Assessing the protein-synthesizing function of the liver, it was found that the total protein content in the serum of white mice depended on the concentrations of the studied hypochlorite-containing drug and the duration of its receipt. In the animals of the first, second, and third experimental groups during the whole period of the experiment (20 days), the level of total protein in the serum was close to that of the animals of the control group. In animals of groups R4 and R5, on the 10th day of the experiment with the highest applied concentrations of Vitosept (400 and 500 mg/L), the content of total protein in the serum of white mice probably decreased by 8.3 and 7.7 %. It is established that such reduction occurs against the background of changes in the fractional composition of proteins. In white mice of group R5 on the 10th day of the experiment revealed a decrease in blood glucose by 5.9 % (P < 0.05), urea – by 7.4 % (P < 0.05), creatinine – by 9.1 % (P < 0.05). The activity of alkaline phosphatase was 32.1 % (P < 0.05) and GGTP – 70 % (P < 0.05) higher than in the blood of animals of the control group. On the 20th day of the experiment, the level of the studied indicators decreased slightly compared to the similar ones on the 10th day. It was within the limit values, although in most cases, it still differed from the indicators of the animals of the control group. It is obvious that when too high concentrations of even a slightly toxic drug are received, the animal's body reacts with a compensatory-adaptive reaction to the arrival of a foreign substance. Thus, we state that the hypochlorite-containing drug “Vitosept” with the long-term intragastric intake of white mice did not cause hepato- and nephrotoxic effects and revealed some deviations in biochemical parameters in animals of the fourth and fifth groups, on the background of 400–500 mg/L, is most likely the result of adaptive-compensatory response to the intake of the test substance.

show abstract

The effect of the drug “Bendamine” on the clinical and morphological parameters of dogs in heart failure

Cited by 9 publications

References 24 publications

Organization of rationed feeding and feeding of dogs

Organization of rationed feeding and feeding of dogs

Experimental evaluation of the acute toxicity and irritant effect of “BTF plus” – a veterinary medicinal product for the normalization of metabolic processes in animals and poultry

Dynamics of individual biochemical parameters of blood of intact white mice under the action of the drug “Vitosept”

Contact Info

Product

Resources

About