The effect of the composition of binary systems on the solubility and solubility parameter estimation of nalidixic and salicylic acids

Effect of propylene glycol on ibuprofen absorption into human skin in vivo

“…Thus, for ibuprofen in PG–water mixtures, solubility is always less than ideal but greater than that predicted by regular solution theory. Further, it appears that solutes may adapt their solubility parameters to the solvent environment in which they are found 29, 35, 36…”

Solubility and phase separation of benzocaine and salicylic acid in 1,4-dioxane–water mixtures at several temperatures

“…Paruta also observed phase separation at 30 • C in a dioxane-water mixture with salicylic acid dissolved. However, Gadalla et al [12] did not describe this effect. The results obtained in the present paper confirm the Paruta findings and show that phase separation occurs at and above 25 • C at dioxane ratios in the range 40-60%.…”

Development of a Predictive Model for the Long-Term Stability Assessment of Drug-In-Adhesive Transdermal Films Using Polar Pressure-Sensitive Adhesives as Carrier/Matrix

“…The observed deviations in the case of SAA may be explained by the fact that SAA formed strong dimers, which impacted its solubility parameter 22 . The solubility parameter of SAA dimer was actually lower, 22.1 MPa 1/2 23,24 , as the dimer was less available for hydrogen bonding, leading to a smaller difference in solubility parameters between drug and PSA and thus higher predicted saturation solubility.…”