The Effect of the Administration of Tetracycline on the Development of Teeth

Histological preparation of teeth and tooth growth

“…The use of low dose tetracycline as a histological hard tissue marker has been well established and allows clear evidence of continued hard tissue growth in experimental animals [11][12][13][14][15][16][17].…”

“…Tetracyclines were introduced in 1948 as broad-spectrum antibiotics that may be used in the treatment of common infections in children and adults [25]. The use of low dose tetracycline as a histological bone marker has been well established since the 1960s with papers by Bevelander et al, [12], Ibsen and Urist [13], Faccini [14], Frost [15], and more recently by Ranggard [11], Engstrom [16], Sun et al, [17]. It was discovered that tetracycline is incorporated into hard tissues calcifying at the time of their administration and subsequently could be studied in undecalcified sections by fluorescence microscopy [12,14].…”

“…When ultraviolet (UV) light (450-490 nanometres [nm]) is applied to tetracycline-stained hard tissues, it exhibits a yellow Fuchsin Fluorescence. Hence tetracycline compounds are utilized in hard tissue research as a vital fluorescent dye for measuring the rate of hard tissue formation [11][12][13][14][15][16]. The tetracycline tends to remain incorporated into the newly formed hard tissue areas for some time after systemic administration [26].…”

Systematic Assessment of Color Removal Following Vital Bleaching of Intrinsically Stained Teeth

“…Two agents, fluoride and tetracycline, ingested during amelogenesis have long been recognized as pre-disposing factors in intrinsic staining (Dean and McKay, 1939;Bevelander et al, 1961). Despite concerted efforts to manage these agents in a manner to prevent occurrences of associated discoloration, these entities continue to present difficult cosmetic problems in the routine practice of dentistry.…”

Studies on the Mineralization of the Calcified Tissue in Molluscs-Ii

“…BEVELANDER et al (1960BEVELANDER et al ( , 1961 and BEVELANDER (1963) have however demonstrated that high concentrations of tetracycline hydrochloride inhibited calcification and mineralization of teeth in rats, of skeleton in sand dollar, and of shell in marine bivalve. Growth rates of the nacre in the Pinctada shell and its pearl were determined utilizing this drug by NAKAHARA (1961).…”