The effect of temperature on asanguineous rabbits

Is lactate a mediator of hypoxia-induced anapyrexia?

“…A wide variety of species, including rats [38], lizards [17] and even a unicellular organism, Paramecium [20], show higher survival rates under hypoxic conditions at lower T c values, usually close to those chosen by these species when subjected to hypoxia. Moreover, mice [2] and rats [34] under hypoxia, rats [35] and pigs [37] with haemorrhagic shock and anaemic rabbits [14] and asphyxiated neonates [11], in all cases being situations in which O 2 supply is limiting, have also shown this correlation. Hypoxia-induced anapyrexia may be beneficial due to the reduction in O 2 consumption, a leftwards shift of the oxyhaemoglobin dissociation curve with a resulting improvement of O 2 loading in the lungs and attenuation of hyperventilation with a resultant blunting of the energetically costly responses to hypoxia [30].…”