The effect of temperature on nasal ciliary beat frequency

Green, A.; Smallman, Lesley A.; Logan, A.; Drake-Lee, Adrian

doi:10.1111/j.1365-2273.1995.tb00040.x

Cited by 63 publications

(50 citation statements)

References 10 publications

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“…The most plausible reason is the peculiar environmental condition of high altitude with low temperature and dry air. The nasal cilia are sensitive to low temperatures and the ciliary beat frequency is known to reduce at lower temperatures [6]. In a study by Salah et al [2], it was demonstrated that breathing dry air at sea level significantly reduces NMTT in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Impact of Nasal Symptoms on the Quality of Life of Fresh Inductees in High Altitude

Datta

Panwar

2008

Medical Journal Armed Forces India

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Background: Troops deployed in high altitude areas of Ladakh face nasal problems in the form of obstructive nasal symptoms and recurrent epistaxis. This study analyses the changes in the nasal mucociliary transit times (NMTT) and deterioration in quality of life of troops on first high altitude induction. Methods: A prospective study on 100 healthy volunteers was done. Mucociliary transit time was measured and a standardized quality of life questionnaire (RQLQ) administered at onset and after a period of three months in high altitude. Thereafter the subjects were divided into two groups and the study group was administered normal saline nasal drops. The observations were taken and results were statistically analysed after a period of three months. Result: The mucociliary transit time was prolonged after a three month stay in high altitude (p< 0.005). Normal saline nasal drops were successful in improving the nasal mucociliary transit times (p < 0.05). There was a statistically significant derangement in the quality of life which was improved by administering normal saline nasal drops (p<0.05). Conclusion: An increased muco-cilliary transport time after exposure to high altitude denotes a deranged physiology of the nasal mucosa. This leads to a statistically significant adverse impact on the quality of life of the troops deployed. The use of normal saline nasal drops is a simple and effective method of reversing some of these changes. MJAFI 2008; 64 : 214-217

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Section: Discussionmentioning

confidence: 99%

Impact of Nasal Symptoms on the Quality of Life of Fresh Inductees in High Altitude

Datta

Panwar

2008

Medical Journal Armed Forces India

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“…35 However, it is not known whether this effect is caused by modulation of kinase activity, even though an acidic pH has been shown to inhibit PKA function, 46 or the direct activation of ODAs of the axoneme. 47 Temperature has also been shown in many investigations to influence CBF, most likely through protein kinase C modulation., 36,37,48 Lower temperature tends to slow CBF. 36 CBF is also regulated by mechanical factors.…”

Section: Dynamic Regulationmentioning

confidence: 99%

Acquired Cilia Dysfunction in Chronic Rhinosinusitis

Gudis

Zhao

Cohen

2012

Am J Rhinol�Allergy

153

136

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Background: Cilia are complex and powerful cellular structures of the respiratory mucosa that play a critical role in airway defense. Respiratory epithelium is lined with cilia that perform an integrated and coordinated mechanism called mucociliary clearance. Mucociliary clearance is the process by which cilia transport the mucus blanket overlying respiratory mucosa to the gastrointestinal tract for ingestion. It is the primary means by which the airway clears pathogens, allergens, debris, and toxins. The complex structure and regulatory mechanisms that dictate the form and function of normal cilia are not entirely understood, but it is clear that ciliary dysfunction results in impaired respiratory defense.Methods: A literature review of the current knowledge of cilia dysfunction in chronic rhinosinsusitis was conducted.Results: Ciliary dysfunction may be primary, the result of genetic mutations resulting in abnormal cilia structure, or, more commonly, secondary, the result of environmental, infectious, or inflammatory stimuli that disrupt normal motility or coordination. Patients with chronic rhinosinusitis (CRS) have been found to have impaired mucociliary clearance. Many biochemical, environmental, and mechanical stimuli have been shown to influence ciliary beat frequency, and common microbial pathogens of respiratory mucosa such as Pseudomonas aeruginosa and Haemophilus influenzae have developed toxins that appear to interrupt normal mucociliary function. Furthermore, inflammatory mediators known to be present in patients with CRS appear to impair secondarily mucociliary clearance. Conclusion:The goal of this article is to summarize the recent developments in the understanding of cilia dysfunction and mucociliary clearance in CRS.

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“…Several rhinopathic conditions may affect both morphology and function in the nasal epithelium, and result in alterations in NMC. These include personal conditions like infection, allergy, nasal obstruction, dust particles, tobacco use, aging [6,9,[19][20][21][22][23][24][25][26] , and environmental conditions like temperature, humidity, altitude and air pollution [27,28] . The effect of age on NMC is under debate.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Nasal Mucociliary Functions with Rhinoscintigraphy in Coal Workers’ Pneumoconiosis

Peksoy

Uğur²,

Altın

et al. 2005

ORL

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Objective: To compare nasal mucociliary clearance (NMC) functions in coal workers with pneumoconiosis, coal workers without pneumoconiosis and healthy controls by using technetium-99m-labeled macroaggregated albumin rhinoscintigraphy. Methods: Sixty-five of the 86 coal workers were clinically documented as suffering from coal workers’ pneumoconiosis (CWP group). CWP workers were divided into two groups according to smoking status: 44 smokers (CWP-S) and 21 nonsmokers (CWP-NS). Twenty-one workers without pneumoconiosis (NCWP group) were similarly divided into two groups: 12 smokers (NCWP-S) and 9 nonsmokers (NCWP-NS). Thirty-three healthy male volunteers were selected for the control group [15 smokers (control-S), 18 nonsmokers (control-NS)]. The half-time (t_½) value for the clearance of the radiopharmaceutical was calculated for each patient. Results: Mean t_½ values for CWP-S, CWP-NS, NCWP-S, NCWP-NS, control-S and control-NS were 25.10 ± 7.75, 10.97 ± 3.24, 14.68 ± 4.98, 9.17 ± 3.71, 19.15 ± 5.04 and 15.08 ± 5.11, respectively (p < 0.001, Kruskal-Wallis variance analysis). Further, mean t_½ values of smokers versus nonsmokers in CWP, NCWP and control groups were compared, and it was found that although smoking prolonged nasal transport time in all three groups, the difference was significant only in the CWP group (p < 0.001, p < 0.023 and p < 0.027, respectively, Bonferroni-adjusted Mann-Whitney test). Conclusion: Our findings demonstrated a synergistic detrimental effect of smoking with coal dust exposure on nasal transport time.

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The effect of temperature on nasal ciliary beat frequency

Cited by 63 publications

References 10 publications

Impact of Nasal Symptoms on the Quality of Life of Fresh Inductees in High Altitude

Impact of Nasal Symptoms on the Quality of Life of Fresh Inductees in High Altitude

Acquired Cilia Dysfunction in Chronic Rhinosinusitis

Evaluation of Nasal Mucociliary Functions with Rhinoscintigraphy in Coal Workers’ Pneumoconiosis

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