The Effect of Telephone-Based Follow-Up on Adherence, Efficacy, and Toxicity of Oral Capecitabine-Based Chemotherapy

Eldeib, Hend K; Abbassi, Maggie; Hussein, Marwa M.; Salem, Salem E.; Sabry, Nirmeen A.

doi:10.1089/tmj.2018.0077

Cited by 29 publications

(41 citation statements)

References 55 publications

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“…Several studies have evaluated telephone call interventions among patients on oral chemotherapy, but did not report the number of patients excluded from the intervention due to non-response. 7,10,[19][20][21][22] However, to our knowledge, this is the first study assessing oncology follow-up call response rates. The mean response rate throughout the six months was less than 50%.…”

Section: Discussionmentioning

confidence: 98%

Factors associated with adherence to follow-up calls in cancer patients receiving care at a community oncology practice

Monestime

Page

Shaw

et al. 2020

J Oncol Pharm Pract

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Background Follow-up calls in the oncology setting are frequently used to augment care and encourage oral antineoplastic adherence. However, limited data are available on patient populations that would benefit from this intervention versus populations that may require alternative interventions. The purpose of this study was to identify characteristics among patients on oral antineoplastic agents that influence their likelihood to respond to follow-up calls. Methods Patients receiving care from one of the eight community oncology clinics within the same branch were analyzed. Patients were included if they were ≥18 years, received a new oral antineoplastic agent that was electronically prescribed between August 2018–October 2018, and picked up their first fill from their pharmacy of choice. Patients received up to six follow-up calls after picking up their first prescription. Calls were categorized as adherent (≥3 monthly interactions) or non-adherent (<3 monthly interactions). Logistic regression models were used to evaluate factors associated with follow-up call adherence. Factors included demographics, cancer stage, marital status, employment, pharmacy setting (internal pharmacy versus external pharmacy), and insurance used by the patient. Descriptive analysis was performed to analyze response rates, cancer diagnosis, and to determine the best time and day patients responded to follow-up calls. Results Data from 125 patients were analyzed, of which 65 patients (52%) were adherent to follow-up calls and the mean response rate over six months was 45% (range: 35% -- 54%). High success rates for follow-up calls were seen between 12–3 pm and on Tuesdays and Thursdays. After adjusting for covariates, patients with stage III-IV were 89% less likely to respond to follow-up calls compared to those with stage 0-II (95% CI: 0.02–0.64; p = 0.01), patients with commercial insurance were 79% less likely to adhere to follow-up calls compared to those on government insurance (95% CI: 0.06-0.71; p = 0.01), and patients using an external pharmacy had a 2.8 times increase odds of being adherent (95% CI 0.98-8.34; p = 0.05). All other factors were not significant. Conclusions For patients taking oral antineoplastics, non-adherence to follow-up calls was observed in more than 45% of patients receiving care from a community oncology clinic. Findings demonstrated that those with advanced stages of cancer, on commercial insurance, and going to an internal pharmacy were at higher risk for not adhering to follow up calls. Therefore, alternative methods for managing adherence and side effects in these populations are warranted.

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Section: Discussionmentioning

confidence: 98%

Factors associated with adherence to follow-up calls in cancer patients receiving care at a community oncology practice

Monestime

Page

Shaw

et al. 2020

J Oncol Pharm Pract

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“…Estratégias de telemonitoramento têm mostrado redução do sofrimento dos pacientes (Beatty, Koczwara, & Wade, 2016). Algumas análises apontam ainda melhora de desfechos, incluindo sobrevida global, com instituição de metodologias as mais distintas de telemonitoramento de sintomas em follow up após tratamentos oncológicos diversos (Basch et al, 2017;Denis et al, 2019;Denis et al, 2017;Eldeib et al, 2019). Além do mais, sentir-se apoiado e monitorado pela equipe de saúde mesmo que de maneira remota ajuda na construção de rapport (Eldeib et al, 2019), o que parece um excelente marcador de experiência de cuidado e pilar fundamental na relação médico-paciente.…”

Section: Discussionunclassified

Telemonitorização de sintomas pós quimioterapia com dispositivos mobile: revisão integrativa da literatura

Moura

Inocêncio

Sant’Ana

et al. 2021

RSD

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O objetivo desse estudo foi avaliar se há benefícios no telemonitoramento de sintomas pós quimioterapia com dispositivos mobile em comparação com modelo tradicional de visitas médicas intervalares no cuidado de pacientes oncológicos, de modo a propiciar ganhos em desfechos prioritários para paciente. Trata-se de uma revisão integrativa de artigos publicados no Pubmed e Scielo nos últimos cinco anos. Termos de busca incluíram cancer, neoplasia, neoplasms, oncology, medical oncology, cancer care facilities, oncology service, telemedicine, telemonitoring, teleoncology, mobile health, mhealth, m-health, e-health, ehealth, videogame, mobile game, mobile app, app-technology, chemotherapy, drug therapy, treatment, drug therapy. Foram incluídos estudos randomizados e controlados, publicados em língua inglesa, pacientes oncológicos expostos a quimioterapia, supervisionados remotamente das toxidades agudas induzidas por quimioterapia, com os dados inseridos por dispositivos mobile. Para extração de dados, dois revisores utilizaram ficha com campos de informação padronizados. Os estudos analisados após critérios de elegibilidade apontam melhor controle de sintomas e desfechos. Conclui-se que telemonitorar toxidade pós quimioterapia por meio de dispositivos mobile gera melhor controle de sintomas e reduz complicações.

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“…While in 2011, Simons et al highlighted increased adherence to capecitabine with a multidisciplinary approach including pharmacists [5]. Hend et al published the effect of telephone-based follow up on adherence, efficacy, and toxicity of oral capecitabine in May 2019 [6]. Within our institution, telephone-based education and monitoring has been the standard of care since the development of our integrated specialty pharmacy in 2015.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Pharmacist Led Oral Chemotherapy Clinic: A Pilot Program in the Gastrointestinal Oncology Clinic at an Academic Medical Center

et al. 2020

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Oral chemotherapy represents a major patient-centric advancement in therapy convenience. However, ownership of safe and correct administration of these agents requires significant patient education. To address this challenge, an in-person pharmacist-led oral chemotherapy education clinic in gastrointestinal oncology patients within an academic medical center was created and assessed. In this pilot program, a medication-specific quiz was administered to patients before and after education performed by a pharmacist to assess patient understanding of their new oral chemotherapy. A five-question satisfaction survey was also administered at the conclusion of the pharmacist clinic visit. Primary outcome was the percentage difference between pre-and post-education quiz scores. Secondary outcomes included patient satisfaction, time to treatment initiation, and number of pharmacist interventions. Frequencies and medians were used to describe categorical and continuous variables, respectively. Of the 18 patients analyzed, 50% were male and median age was 59.5 years. Approximately 28% had colon cancer, and 61% were treated with capecitabine. The median post-education scores improved from a pre-education score of 75% to 100%. Overall, seventeen of the eighteen patients responded with “strongly agree” to all satisfaction survey statements. An in-person oncology pharmacist-led oral chemotherapy education session demonstrated an improvement in patients’ understanding of their new oral chemotherapy treatment.

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The Effect of Telephone-Based Follow-Up on Adherence, Efficacy, and Toxicity of Oral Capecitabine-Based Chemotherapy

Cited by 29 publications

References 55 publications

Factors associated with adherence to follow-up calls in cancer patients receiving care at a community oncology practice

Factors associated with adherence to follow-up calls in cancer patients receiving care at a community oncology practice

Telemonitorização de sintomas pós quimioterapia com dispositivos mobile: revisão integrativa da literatura

Evaluation of a Pharmacist Led Oral Chemotherapy Clinic: A Pilot Program in the Gastrointestinal Oncology Clinic at an Academic Medical Center

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