The effect of tectorial membrane and basilar membrane longitudinal coupling in cochlear mechanics

Meaud, Julien; Grosh, Karl

doi:10.1121/1.3290995

Cited by 120 publications

(140 citation statements)

References 40 publications

(61 reference statements)

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“…by reducing the longitudinal spread of excitation [8], allowing adjacent regions of the cochlea to vibrate at their own local best frequencies.…”

Section: Discussionmentioning

confidence: 99%

“…However, more recent experiments that show longitudinally propagating traveling waves along the TM challenge this notion [4]. The presence of a second cochlear traveling wave has important implications for auditory mechanisms [4,6,8,9], particularly in light of a new mouse model with genetically altered hearing (Tectb −/− ) [10]. Tectb −/− mice have reduced sensitivity, but strikingly sharper frequency selectivity that is difficult to explain with conventional theories of cochlear amplification.…”

Section: Introductionmentioning

confidence: 97%

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Tectorial Membrane Traveling Waves Underlie Impaired Hearing in Tectb Mutant Mice

Ghaffari¹,

Farrahi²,

Aranyosi³

et al. 2011

AIP Conference Proceedings

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Abstract. We show that the Tectb mutation reduces the spatial extent and propagation velocity of tectorial membrane (TM) traveling waves. These results can account for all of the hearing abnormalities associated with the Tectb mutation, as follows. By reducing the spatial extent of TM waves, the Tectb mutation decreases spread of excitation and thereby increases frequency selectivity at mid-to high frequencies. Furthermore, the decrease in Tectb TM wave velocity at low frequencies reduces the number of hair cells that effectively couple energy to the basilar membrane, which thereby reduces sensitivity.

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“…by reducing the longitudinal spread of excitation [8], allowing adjacent regions of the cochlea to vibrate at their own local best frequencies.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Tectorial Membrane Traveling Waves Underlie Impaired Hearing in Tectb Mutant Mice

Ghaffari¹,

Farrahi²,

Aranyosi³

et al. 2011

AIP Conference Proceedings

View full text Add to dashboard Cite

show abstract

“…The past decade has brought remarkable advances in the understanding of the micromechanics of the auditory system and its components (Barral and Martin 2011;Brownell et al 2011;Cheatham and Dallos 2000;Dong and Olson 2009;Eiber 2008;Elliott et al 2007Elliott et al , 2011Eze and Olson 2011;Fettiplace 2006;Fisher et al 2012;Gao et al 2013;Gavara and Chadwick 2009;Gavara et al 2011;Gu et al 2008;He et al 2008;Hemila et al 2010;Hong and Freeman 2006;Jacob et al 2009;Kapadia and Lutman 2000;Kitani et al 2011;Kolston 2000;Grosh 2011, Meaud andGrosh 2010;Naidu and Mountain 2007;Nam and Fettiplace 2012;Ren and Nuttall 2000;Rhode 2007;Santos-Sacchi 2008;Van Dijk et al 2011;Zhang et al 2007;Zheng et al 2007). Quantitative descriptions of basilar membrane motion patterns are available for the base and the apex of the mammalian cochlea (e.g., Olson et al 2012;Robles and Ruggero 2001).…”

Section: Introductionmentioning

confidence: 99%

Basilar Membrane and Tectorial Membrane Stiffness in the CBA/CaJ Mouse

Teudt

Richter

2014

JARO

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The mouse has become an important animal model in understanding cochlear function. Structures, such as the tectorial membrane or hair cells, have been changed by gene manipulation, and the resulting effect on cochlear function has been studied. To contrast those findings, physical properties of the basilar membrane (BM) and tectorial membrane (TM) in mice without gene mutation are of great importance. Using the hemicochlea of CBA/CaJ mice, we have demonstrated that tectorial membrane (TM) and basilar membrane (BM) revealed a stiffness gradient along the cochlea. While a simple spring mass resonator predicts the change in the characteristic frequency of the BM, the spring mass model does not predict the frequency change along the TM. Plateau stiffness values of the TM were 0.6±0.5, 0.2± 0.1, and 0.09±0.09 N/m for the basal, middle, and upper turns, respectively. The BM plateau stiffness values were 3.7±2.2, 1.2±1.2, and 0.5±0.5 N/m for the basal, middle, and upper turns, respectively. Estimations of the TM Young's modulus (in kPa) revealed 24.3±25.2 for the basal turns, 5.1±4.5 for the middle turns, and 1.9±1.6 for the apical turns. Young's modulus determined at the BM pectinate zone was 76.8±72, 23.9±30.6, and 9.4±6.2 kPa for the basal, middle, and apical turns, respectively. The reported stiffness values of the CBA/CaJ mouse TM and BM provide basic data for the physical properties of its organ of Corti.

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“…¼ 2% f ) and m 1 is the BM mass per unit area. This equation ignores the longitudinal coupling motion reported by Meaud and Grosh [26] because the model does not include the longitudinal coupling of the BM. Figure 7 shows the isolevel contours of the cubic distortion 2 f 1 À f 2 .…”

Section: Distortion Productsmentioning

confidence: 99%

Input level dependence of distortion products generated by saturating feedback in a cochlear model

Murakami

Ishimitsu

2016

Acoust. Sci. & Tech.

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In this paper, we demonstrate how feedback from a saturation function can explain the generation mechanisms of cochlear distortion products (DPs) using a transmission line model of the cochlea, two simple nonlinear phenomenological models, and a power-law nonlinear model. The first model includes feedback via a saturating element that models outer hair cell motility toggled by mechanoelectric transduction. The second models focus on the saturation process in the cochlea, and result in either feed-forward or feedback. The third model can fit compressive growth in the cochlear input-output function. The models show compressive growth in input-output properties for a single tone and generate DPs at moderate input levels for two tones. The results of the transmission line model show a good fit to the experimental results. DP levels are concentrated when the levels of the two tones are equal in the simple feed-forward model and are widely distributed in the simple feedback model. The simple feedback model shows similar results to the transmission line model, with the exception of the dependence on the frequency rate. The results of the power-law nonlinear model with an appropriate power are comparable to the results of the simple feedback model. These results suggest that the saturating feedback process generates appropriate power-law nonlinearity and can account for the input level dependence of DP generation in the cochlea.

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The effect of tectorial membrane and basilar membrane longitudinal coupling in cochlear mechanics

Cited by 120 publications

References 40 publications

Tectorial Membrane Traveling Waves Underlie Impaired Hearing in Tectb Mutant Mice

Tectorial Membrane Traveling Waves Underlie Impaired Hearing in Tectb Mutant Mice

Basilar Membrane and Tectorial Membrane Stiffness in the CBA/CaJ Mouse

Input level dependence of distortion products generated by saturating feedback in a cochlear model

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