The effect of systemically administrated zoledronic acid on the osseointegration of dental implants

Abstract

A single dose of systemic ZA administration increases the rate of NBF and augments the quality of the bone.

Influence of the local application of sodium alendronate gel on osseointegration of titanium implants

“…The influence of the use of bisphosphonates in implant dentistry has been studied extensively, both their systemic use [27][28][29] and local use by means of direct application to the surgical alveolus 13,22,23,25 or by immobilization of the medication on the implant surface. 7,15,16,[19][20][21] In this study, local application of bisphosphonate was used in order to benefit from its biomodulating influence on osseointegration in the absence of the possible systemic effects of this drug.…”

The influence of high‐dose systemic zoledronate administration on osseointegration of implants with different surface topography

“…In the present study, we have demonstrated that moderately rough surface implants, prepared using the same methods used to manu- following ibandronate administration in rabbit femur 40 or ZA administration in rabbit tibia, 41,42 while others have failed to produce statistically significant differences following alendronate administration in rabbit femur. 43 Furthermore, the extrapolation of animal data on osseointegration in long bone to the clinical situation within the oral cavity has to be interpreted with caution.…”

“…A limited number of studies to date have demonstrated the influence of BPs, and ZA in particular, on osseointegration in non‐estrogen deficient animals such as those used in the present study. Several pre‐clinical animal trials have used histomorphometric analysis to show an improvement in osseointegration, following ibandronate administration in rabbit femur or ZA administration in rabbit tibia, while others have failed to produce statistically significant differences following alendronate administration in rabbit femur . Recently, de Olivier and co‐workers (2014) demonstrated no statistical differences in the values of BIC (%) for the entire observational periods after the surgical placement of titanium implants in rat tibiae between the ZA and control groups.…”

“…Indeed, when a delayed BP dose is administered, this would not affect the wound healing during osseointegration, but is likely to reduce the rate of subsequent remodeling by decreasing catabolism . Yaman et al (2012) and Ayan et al (2012) investigated the influence of a single dosage of ZA administered at the time of implant surgery in rabbit tibia . They were able to demonstrate that BIC was improved in the ZA‐treated animals compared to untreated animals which may be explained by the time lag between administration and mechanism of action of the drug at the local site of implant placement.…”

“Bisphosphonates: Possible Modes of Action and Implications for Dental Implant Treatment. A Review of the Literature”

“…Review of the current literature reflects a limited, but growing, knowledge of the relative risks to dental implant treatment in patients receiving bisphosphonate medication [139,[170][171][172][173][174][175][176][177][178][179]. There have been several case reports and series that have evaluated implant failures in patients receiving intravenous bisphosphonate therapy [180], while other retrospective studies have indicated that there may be risks of osteopathology developing in patients receiving oral bisphosphonates and dental implant treatment [10][11][12][13][14].…”