The effect of systemic melatonin administration on the intensity of free radical damage to lipids and proteins in the burn wound in the dynamics of experimental thermal injury
Abstract:Aim. To assess the effect of melatonin (MT) on the content of lipid peroxidation (LPO) and protein oxidation (PO) products in the tissue homogenate from the burn wound in experimental thermal injury (TI).Materials and methods. Third-degree (IIIA) TI with a relative area of 3.5% was modeled on male Wistar rats via contact of the skin with boiling water. Intraperitoneal administration of MT (10 mg / kg) was performed once a day for 5 days. On days 5, 10, and 20, LPO products in the heptane and isopropanol phases… Show more
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