The Effect of Systemic Lidocaine on Pain and Secondary Hyperalgesia Associated with the Heat/Capsaicin Sensitization Model in Healthy Volunteers

Abstract

The efficacy of systemic lidocaine in nonneuropathic pain remains uncertain. This study investigates the effect of systemic lidocaine on experimental-induced hyperalgesia in 25 volunteers. Hyperalgesia was induced by using an experimental pain model that uses heat and capsaicin in combination. Systemic lidocaine showed a selective effect on secondary hyperalgesia.

Gender Differences in Pain and Secondary Hyperalgesia After Heat/Capsaicin Sensitization in Healthy Volunteers

“…5,15,32 Moreover, in studies assessing analgesic effect, the analgesic effect on areas assessed with brush and von Frey hair have not always correlated with each other, especially in studies in which the overall study effect size was small. 4,12,38 Future studies, primarily in the basic sciences, are needed to investigate the molecular basis underlying gender differences in neuronal transmission and sensitization.…”

Intravenous lidocaine has no impact on rocuronium‐induced neuromuscular block. Randomised study

“…It has anti-arrhythmic, 1 analgesic, [2][3][4] antihyperalgesic, [5][6][7] and anti-inflammatory properties, 8 and it reduces intraoperative requirements for various volatile anaesthetics. 9,10 Systematic review of randomised trials suggested that an intraoperative lidocaine infusion may have a beneficial effect on bowel function, analgesia, and length of hospital stay after major abdominal surgery.…”

A randomized study of the effects of perioperative i.v. lidocaine on hemodynamic and hormonal responses for cesarean section

“…In all of the infusion studies, lidocaine was given in the 2-3 mg·min −1 range, resulting in plasma levels ranging from 1 to 5 μg·mL −1 [23]. We found that continuous lidocaine infusion led to a plateau of the plasma concentration of lidocaine well below the toxic range of 5.0 μg·mL −1 , with no reported adverse effects.…”