The effect of synthetic dermal secretion on transfer and dissipation of the insecticide aldicarb from granular formulation to fabric

Abstract

This research investigated the potential for contamination of fabric by aldicarb (Temik 15) pesticide. Fabric soiled with synthetic perspiration or synthetic sebum was contaminated with Temik granules for various time periods and extracted with methanol. Extracts were analyzed with high performance liquid chromatography. The aldicarb transferred to both soiled and unsoiled fabric; however, the sebum soil and longer contact time increased the transfer of aldicarb to fabric. The dissipation of aldicarb from fabric was affected by the soil type and the formulation of the Temik granule. It is apparent a potential for dermal exposure to granular pesticide exists when the pesticide is trapped in pockets or folds of clothing.

Human synthetic sebum formulation and stability under conditions of use and storage

“…A formulation used by Nelson et al. [12] contained squalene, triglyceride, fatty acid, a high proportion of cholesterol and octadecanol. This formulation lacked wax ester and contained an unrealistically high proportion of cholesterol and included octadecanol, which is not found on the human skin surface.…”

“…The presence of a hydrophobic lipid film at the skin surfaces could have significant effects on hydration and smoothness of the skin surface, the luster of hair and on penetration of a range of materials into skin and hair. One example of a use for synthetic sebum formulation is to determine if sebum altered adsorption of the pesticide, Aldicarb [12]. Synthetic sebum could similarly be used for soiling fabric for testing laundry detergents or for creating standardized tests for personal care products, such as soaps and shampoos.…”