The effect of surgery and anesthetic agents on granulocyte-chemiluminescence in whole blood

Abstract

The effect of anesthesia and major abdominal surgery on zymosan-induced chemiluminescence (CL) of neutrophil granulocytes was evaluated. CL was measured in diluted whole blood taken at distinct intervals within the perioperative period. In addition, blood samples from healthy volunteers were supplemented with ether and halothane to investigate the in vitro effect of these agents. The phagocytosis-induced CL was not found to be depressed by anesthesia and surgery. Only at supranarcotic concentrations was CL reduced. Surgery and anesthesia, therefore, do not appear to impair this defense system significantly under the conditions of this investigation.

Comparison of the effects of four i.v. anaesthetic agents on polymorphonuclear leucocyte function

“…Several investigators have found an in vitro decrease in PMN free radical production [13][14][15] and a decrease in phagocytosis in vitro [16,17] and in vivo [18][19][20] in PMN exposed to anaesthetic agents. Other studies have not confirmed these changes in PMN functional variables [21][22][23][24][25][26]. As a result of such contradictory data, useful conclusions have been difficult to obtain.…”

Effects of desflurane, sevoflurane and propofol on phagocytosis and respiratory burst activity of human polymorphonuclear leucocytes in bronchoalveolar lavage

“…Several investigators have found an in-vitro decrease in PMN free radical production [9,10] and a decrease in phagocytosis in vitro [11,12] and in vivo [13][14][15] in peripheral blood. Other studies have not confirmed these changes in PMN functional variables [16][17][18][19]. As a result of such contradictory data, useful conclusions have been difficult to obtain [1].…”