The effect of suramin-phthalanilide complexes on the chemotherapeutic activity and toxicity of 4′,4″-bis (1,4,5,6-tetrahydro-2-pyrimidinyl)terephthalanilide (NSC 57153)

Yesair, David W.; Wodinsky, I; Rogers, William I.; Kensler, C. J.

doi:10.1016/0006-2952(68)90334-1

Cited by 7 publications

(1 citation statement)

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“…2B). This molar ratio of suramin‐acridine orange complex, which is constant at least up to 800 μM of acridine orange, is essentially identical with that reported for the complex of suramin and 4′,4″‐bis (1,4,5,6‐tetrahydro‐2‐pyrimidinyl) terephthalanilide (a weak‐base aromatic compound analogous to acridine orange) [33]. These results show that acridine orange can be used as a reporter compound for probing the entry of suramin into acidic intracellular compartments.…”

Section: Resultssupporting

confidence: 85%

Suramin enters and accumulates in low pH intracellular compartments of v‐sis‐transformed NIH 3T3 cells

1997

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Using acridine orange as a reporter compound, we demonstrate that suramin enters and accumulates in low pH intracellular compartments (endosomes, lysosomes, and transGolgi complex) of normal and v-sis-transformed NIH 3T3 cells. The concentration of suramin in these acidic compartments is estimated to be > 150 μΜ, higher than the concentration known to completely inhibit interaction of the platelet-derived growth factor (PDGF) receptor and v-sis gene product. These results support the hypothesis that suramin reverses the transformed phenotype of v-sis-transformed cells by entering the cell via endocytosis and blocking interaction of the v-sis gene product and PDGF receptor in intracellular organdies.

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Section: Resultssupporting

confidence: 85%