The Effect of Supervised Exercise Training on Symptoms of Chemotherapy-Induced Peripheral Neuropathy

Wonders, Karen Y.

doi:10.4172/2329-9096.1000210

Cited by 17 publications

(11 citation statements)

References 21 publications

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“…Physical activity and lifestyle interventions with cancer survivors have been shown to be efficacious for both weight [31, 32] and pain management [33], as well as improving HRQoL [34–36]. Evidence is emerging that physical activity is effective in ameliorating CIPN symptoms in particular [37, 38]. Interventions using components of cognitive behavioral therapies have also been successful in targeting a range of issues pertinent to cancer survivorship [39, 40], including weight management [40], pain [41, 42], and HRQoL [43, 44].…”

Section: Discussionmentioning

confidence: 99%

Disease burden and pain in obese cancer patients with chemotherapy-induced peripheral neuropathy

Cox-Martin

Trahan

Cox

et al. 2017

Support Care Cancer

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Purpose Chemotherapy-induced peripheral neuropathy (CIPN) and obesity are prevalent in cancer survivors and decrease quality of life; however, the impact of the co-occurrence of these conditions has garnered little attention. This study investigated differences between obese and non-obese cancer survivors with CIPN and predictors of symptom burden and pain. Methods Patients with CIPN were administered the MD Anderson Symptom Inventory and a modified version of pain descriptors from the McGill Pain Inventory. Independent t tests assessed group differences between obese and non-obese survivors, and linear regression analyses explored predictors of patient outcomes. Results Results indicated a significant difference in symptom severity scores for obese (M = 32.89, SD = 25.53) versus non-obese (M = 19.35, SD = 16.08) patients (t(37.86) = −2.49, p = .02). Significant differences were also found for a total number of pain descriptors endorsed by obese (M = 4.21, SD = 3.45) versus non-obese (M = 2.42, SD = 2.69) participants (t(74) = −2.53, p = .01). Obesity was a significant predictor of symptom severity and total pain descriptors endorsed. Other significant predictors included age and months since treatment. Conclusions Cancer survivors with CIPN and co-occurring obesity may be more at risk for decreased quality of life through increased symptom severity and pain compared to non-obese survivors. This paper identified risk factors, including obesity, age, and months since treatment, that can be clinically identified for monitoring distress in CIPN patients. Future research should focus on the longitudinal relationship between obesity and CIPN, and robust interventions to address the multifaceted issues faced by cancer survivors.

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Section: Discussionmentioning

confidence: 99%

Disease burden and pain in obese cancer patients with chemotherapy-induced peripheral neuropathy

Cox-Martin

Trahan

Cox

et al. 2017

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“…Also clinical trial conducted on patients investigated the role of exercise in the management of peripheral neuropathy [ 71 ]. Two studies that tested a structured 10-12 weeks exercise programs (one supervised, the other home-based) found that exercise training reduces CIPN symptoms, such as unpleasant skin sensations, sensitivity related to neuropathic pain and the experience of coming on suddenly in bursts for no apparent reason [ 87 , 88 ].…”

Section: Physical Aspectsmentioning

confidence: 99%

Impact of physical exercise in cancer survivors during and after antineoplastic treatments

et al. 2018

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Cancer patients experience symptoms and adverse effects of treatments that may last even after the end of treatments. Exercise is a safe, non-pharmacological and cost-effective therapy that can provide several health benefits in cancer patient and survivors, reducing cancer symptoms and cancer treatment side effects. The purpose of this review is to describe how the physical exercise is capable to reduce cancer symptoms and cancer treatment side effects. We realized a pragmatic classification of symptoms, dividing them into physical, psychological and psycho-physical aspects. For each symptom we discuss causes, therapies, we analyse the effects of physical exercise and we summarize the most effective type of exercise to reduce the symptoms. This review also points out what are the difficulties that patients and survivors face during the practice of physical activity and provides some solutions to overcome these barriers.Related to each specific cancer, it emerges that type, frequency and intensity of physical exercise could be prescribed and supervised as a therapeutic program, like it occurs for the type, dose and duration of a drug treatment.

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“…A follow-up investigation examined the effect of 12 weeks of supervised exercise training on symptoms of CIPN and found that exercise training positively impacted neurological function. Specifically, unpleasant skin sensations and sensitivity related to neuropathic pain were attenuated following chronic exercise training [57].…”

Section: Exercise Rehabilitationmentioning

confidence: 97%

The Role of Exercise in Chemotherapy-Induced Peripheral Neuropathy

Wonders¹,

Stout²

2016

Neurooncology - Newer Developments

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Chemotherapy-induced peripheral neuropathy CIPN is the most common neurological side effect of chemotherapy and is characterized by damage to the nervous system that is a direct result of the medications associated with chemotherapy. Often, this damage to the central nervous system pain pathways results in neuropathic pain described as burning, paroxysmal, stabbing, or elective shock-like and accompanied by pins-andneedles sensations and itching. The presence and severity of neuropathic pain is often shown to be associated with impairments in walking, general activities, sleep, work, mood, enjoyment of life, and relationships with others. Treatment of neuropathic pain due to CIPN often requires a multidisciplinary approach due to the broad variety of symptoms and their negative impact on quality of life. To provide treatment strategies that are effective for patients, they should include a combination of pharmacological agents and exercise rehabilitation. Exercise rehabilitation programs should be designed in order to help patients familiarize themselves to changes in physical functioning. The goals of the program should target three main areas maximize functional capacities, prolong or maintain independent function, and improve quality of life.

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The Effect of Supervised Exercise Training on Symptoms of Chemotherapy-Induced Peripheral Neuropathy

Cited by 17 publications

References 21 publications

Disease burden and pain in obese cancer patients with chemotherapy-induced peripheral neuropathy

Disease burden and pain in obese cancer patients with chemotherapy-induced peripheral neuropathy

Impact of physical exercise in cancer survivors during and after antineoplastic treatments

The Role of Exercise in Chemotherapy-Induced Peripheral Neuropathy

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