The Effect of Sufentanil Administration on Remifentanil-Based Anaesthesia during Laparoscopic Gynaecological Surgery: A Double-Blind Randomized Controlled Trial

Abstract

This study assessed the effect of sufentanil administered before conclusion of remifentanil-based anaesthesia on postoperative hyperalgesia and haemodynamic stability in patients undergoing laparoscopic gynaecological surgery. The patients were randomly allocated to a sufentanil administration group (S group) or a normal saline administration group (C group). Anaesthesia was induced and maintained with controlled administration of remifentanil at 10 ng·mL−1 and propofol under bispectral index guidance. Once the surgical specimen was procured, sufentanil or normal saline was administered at 0.15 ng·mL−1 and maintained until extubation. The haemodynamic status during anaesthetic emergence was evaluated. The pain and postoperative nausea and vomiting (PONV) were assessed for 72 h following postanaesthetic care unit (PACU) discharge. The S group had significantly lower mean systemic arterial blood pressure and heart rate changes between the start of drug administration and extubation. Postoperative pain was significantly lower in the S group until 24 h following PACU discharge. There were no significant differences in PONV incidence and severity 72 h after PACU discharge between the two groups. Sufentanil administration before concluding remifentanil-based anaesthesia improved postoperative hyperalgesia and achieved haemodynamic stability at extubation without delaying recovery or increasing PONV during laparoscopic gynaecological surgery. Clinical trial registration is found at KCT0000785.

The impact of sufentanil versus remifentanil on surgical site wound healing in caesarean section primiparas undergoing epidural anaesthesia: A systematic meta‐analysis

“…Effective analgesia can reduce stress responses postsurgery, which in turn can facilitate better wound healing outcomes. 18,19 However, it is essential to consider the potential side effects associated with these opioids. As mentioned, the combination of ropivacaine with sufentanil has been associated with a higher incidence of pruritus and numbness, 1,20 which could impact patient comfort and overall satisfaction.…”

“…Our findings are consistent with previous research that has emphasized the importance of optimal pain management in promoting wound healing. Effective analgesia can reduce stress responses postsurgery, which in turn can facilitate better wound healing outcomes 18,19 . However, it is essential to consider the potential side effects associated with these opioids.…”

Effect of additional equipotent fentanyl or sufentanil administration on recovery profiles during propofol-remifentanil–based anaesthesia in patients undergoing gynaecologic laparoscopic surgery: a randomized clinical trial

“…In a recent study, Son et al [26] reported that in patients undergoing GLS, sufentanil administered before the conclusion of remifentanil anaesthesia reduced postoperative hyperalgesia and achieved haemodynamic stability during extubation without delaying recovery or worsening PONV. Sufentanil administration during remifentanil-based complete intravenous anaesthetic induction is linked to lower early postoperative opioid use [27].…”

<p>Effects of Additional Intraoperative Administration of Sufentanil on Postoperative Pain, Stress and Inflammatory Responses in Patients Undergoing Laparoscopic Myomectomy: A Double-Blind, Randomized, Placebo-Controlled Trial</p>

“…The standard visual analogue scale (VAS), ranging from 0 to 10 cm (0 means no pain;10 cm describes the worst pain imaginable), 22 was explained to the patients during the preoperative visit and the patients should slide the ruler every time the pain is assessed. A statistician who was unaware of the design of the study randomly and equally divided patients into two groups by using a computer-generated random number table: Test group (group T), 0.2μg/kg sufentanil (prepared by a independent anesthesiologist and diluted into 10mL) was given 1h before the end of the surgery; and Control group (group C), an equivalent volume of normal saline (prepared by the independent anesthesiologist and diluted into 10mL).…”