The Effect of Succinylcholine on the Isolated Mammalian Heart

Goat, V. A.

doi:10.1097/00132586-197302000-00005

Cited by 2 publications

(3 citation statements)

References 18 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BUCCINO et al (1966) found no basis for a norepinephrine-mediated action, but found evidence for the presence of two different cholinergic receptors in the heart: a muscarinic (type I) receptor associated with vagal nerve endings, responding to small doses of acetylcholine; and a spatially separate type I1 receptor, with an action similar to the classical nicotinic and responding to large doses. I n a similar way the biphasic action of suxamethonium on heart rate has been explained by a dose-dependent effect on changeable muscarinic receptors (GOAT 1972).…”

Section: Dlscussionmentioning

confidence: 84%

Arrhythmias During Halothane Anesthesia IV. The Influence of a Single Dose of Suxamethonium

Andersen

Eikard

1979

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

The effect of a single dose of suxamethonium on cardiac rate and rhythm during halothane anesthesia with babiturate induction was studied in a prospective, triple-blind trial with 28 patients. No atropine was given and patients were not intubated. A slight but significant preponderance of sinus-bradycardia without hemodynamic consequences was found in the group given suxamethonium. Suxamethonium did not provoke ventricular ectopies or conduction disturbances. It is concluded that in anesthesia with barbiturate induction, but without atropine or intubation, the use of a single dose of suxamethonium is a safe procedure with regard to cardiac rate and rhythm.

show abstract

Section: Dlscussionmentioning

confidence: 84%

Arrhythmias During Halothane Anesthesia IV. The Influence of a Single Dose of Suxamethonium

Andersen

Eikard

1979

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

“…Initial H R was significantly higher in women than in men (P=O.O009), mean values (s.d.) being 81 (9) and 70 (lo), respectively. For initial MAP a significant increase with increasing age was found (P=O.Ol).…”

Section: Resultsmentioning

confidence: 99%

“…The precise site of action of suxamethonium is still controversial. Because of the structural similarity to acetylcholine, interaction with cholinergic receptors of both the muscarinic and the nicotinic type is possible (9). The ultimate change in H R following suxamethonium thus probably reflects a net effect of several different mechanisms such as stimulation of both vagal and sympathetic ganglia, stimulation of the sinus node or reflex action of the vagus nerve (1 1-14).…”

Section: Discussionmentioning

confidence: 99%

The influence of fentanyl on the cardiovascular effect of suxamethonium

Engbaek

Sørensen

Østergaard

et al. 1986

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

The influence of fentanyl on the cardiovascular effect of a single dose of suxamethonium was evaluated during thiopentone N2O/O2 anaesthesia. Sixty adult patients were randomly allocated to three groups. In one group (control group) no fentanyl was given. In two groups fentanyl 0.002 mg/kg and 0.004 mg/kg, respectively, was given before induction of anaesthesia. Three minutes after the injection of suxamethonium 1 mg/kg, both heart rate (HR) and mean arterial pressure (MAP) in the two groups receiving fentanyl were significantly lower than in the control group. However, the absolute changes were small and no dose-related effect was seen. An estimation of the change in HR following suxamethonium was made using as predictors initial HR before induction of anaesthesia, age, sex, and the injection of fentanyl. The higher the initial HR, the greater was the chance of a decrease in HR following suxamethonium. Injection of fentanyl lowered the threshold HR above which a decrease was to be expected following injection of suxamethonium. This effect was most pronounced among the younger patients. It is concluded that injection of fentanyl potentiates the decrease in HR sometimes seen after a single dose of suxamethonium and that this effect is influenced by HR before induction of anaesthesia and by age of the patient.

show abstract

The Effect of Succinylcholine on the Isolated Mammalian Heart

Abstract: Succinylcholine is a bis-choline ester of succinic acid. Structurally it is similar to two molecules of acetylcholine.CH,

Cited by 2 publications

References 18 publications

Arrhythmias During Halothane Anesthesia IV. The Influence of a Single Dose of Suxamethonium

Arrhythmias During Halothane Anesthesia IV. The Influence of a Single Dose of Suxamethonium

The influence of fentanyl on the cardiovascular effect of suxamethonium

Contact Info

Product

Resources

About