The effect of subthalamic deep brain stimulation on autonomic dysfunction in Parkinson’s disease: clinical and electrophysiological evaluation

Yavaşoğlu, Neşe Güngör; Çomoğlu, Selçuk

doi:10.1080/01616412.2021.1942409

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Deep brain stimulation ameliorates gastrointestinal dysfunctions (42). Subthalamic nucleus deep brain stimulation is an important option for treating eating, sweating, absorption, metabolism, and excretion disorders (43). Deep brain stimulation also modulates oropharyngeal swallowing process arising from olfactory disorders.…”

Section: Deep Brain Stimulation and Salivationmentioning

confidence: 99%

New determinants for causal neural mechanism of dry mouth in Parkinson’s disease induced by destruction of superior salivatory nucleus, facial nerve, and submandibular gland circuitry: an experimental study

Zeynal¹

2023

Anatolian Current Medical Journal

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Aim: Dry mouth has been considered a clinical finding of Parkinson’s disease (PD), but we think otherwise. We studied if the olfactory bulbectomy (OBX) might rely on the superior salivatory nucleus (SSN), submandibular ganglia (SMGn), and submandibular glands (SLGl) circuity disruption induced submandibular gland degeneration related dry mouth in rats. Material and Method: This study was carried out on twenty-six male rats. Five (GI-n=5), six (GII, n=6), and sixteen (GIII, n=15) of them were used as control, SHAM, and OBX groups, respectively, and followed eight weeks. PD-related clinical examinations were done before and after the experiment (1/day), and animals were decapitated. The olfactory bulb volumes (mm3), degenerated neuron densities of SSN/SMG (n/mm3 and SMGl follicles volumes were detected serologically. Olfactory bulb volume values and degenerated neuron density values of SSN/SMGn/SMGl follicles volumes were compared statistically. Results: OBX-applied animals showed anosmia, tremors, rigidity, and memory loss. The mean olfactory bulb volumes (mm3), degenerated neuron density of SSN (n/mm3), SMGn (n/mm3), and follicles volumes of SMGl (cubic micrometer/mm3) were measured in the order written as; (4.27±0.21), (4±1), (5±2), (81.23±13.34).106 in GI; (3.67±0.33), (14±3), (17±4), (72.45±11.78).106 in GII and (2.91±0.14), (23±5), (29±8), (57.19±11.93).106 in Group III. The mean P values between olfactory bulb volumes, degenerated neuron densities of SSN and SMGn, and salivary follicles volumes were: p

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Section: Deep Brain Stimulation and Salivationmentioning

confidence: 99%

New determinants for causal neural mechanism of dry mouth in Parkinson’s disease induced by destruction of superior salivatory nucleus, facial nerve, and submandibular gland circuitry: an experimental study

Zeynal¹

2023

Anatolian Current Medical Journal

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“…However, in severely affected patients, currently available therapies may not suffice in improving symptoms. Novel therapies such as spinal cord pacing [119] or deep brain stimulation [120] may have utility in this setting. We certainly hope that the engineering expertise, which is constantly pushed to its limit in space research, will yield new treatments for our patients with orthostatic intolerance on Earth.…”

Section: Applications On Earthmentioning

confidence: 99%

Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine

2022

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Background The harsh environmental conditions during space travel, particularly weightlessness, impose a major burden on the human body including the cardiovascular system. Given its importance in adjusting the cardiovascular system to environmental challenges, the autonomic nervous system has been in the focus of scientists and clinicians involved in human space flight. This review provides an overview on human autonomic research under real and simulated space conditions with a focus on orthostatic intolerance. Methods The authors conducted a targeted literature search using Pubmed. Results Overall, 120 articles were identified and included in the review. Conclusions Postflight orthostatic intolerance is commonly observed in astronauts and could pose major risks when landing on another celestial body. The phenomenon likely results from changes in volume status and adaptation of the autonomic nervous system to weightlessness. Over the years, various non-pharmacological and pharmacological countermeasures have been investigated. In addition to enabling safe human space flight, this research may have implications for patients with disorders affecting cardiovascular autonomic control on Earth.

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The rapid recovery of the sympathetic skin response in a patient with Parkinson’s disease with STN-DBS

2022

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The effect of subthalamic deep brain stimulation on autonomic dysfunction in Parkinson’s disease: clinical and electrophysiological evaluation

Cited by 3 publications

References 31 publications

New determinants for causal neural mechanism of dry mouth in Parkinson’s disease induced by destruction of superior salivatory nucleus, facial nerve, and submandibular gland circuitry: an experimental study

New determinants for causal neural mechanism of dry mouth in Parkinson’s disease induced by destruction of superior salivatory nucleus, facial nerve, and submandibular gland circuitry: an experimental study

Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine

The rapid recovery of the sympathetic skin response in a patient with Parkinson’s disease with STN-DBS

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