The effect of substance P and its specific antagonist (aprepitant) on the expression of MMP-2, MMP-9, VEGF, and VEGFR in ovarian cancer cells

Razmgah, Maryam Momen; Ghahremanloo, Atefeh; Javid, Hossein; Alalikhan, Abbas; Afshari, Amir-R; Hashemy, Seyed Isaac

doi:10.1007/s11033-022-07771-w

Cited by 11 publications

(7 citation statements)

References 40 publications

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“…The underlying mechanism is still controversial. Momen ( 34 ) contributed the aprepitant-related angiogenesis to MMP-2, MMP-9, VEGF, and VEGFR. On the other hand, regulation of EGFR, Akt, and SIRT1 by NK1R blockade was also considered beneficial in terms of re-epithelialization and collagen deposition ( 35 – 37 ).…”

Section: Discussionmentioning

confidence: 99%

Potential therapeutic effect of NK1R antagonist in diabetic non-healing wound and depression

Ma²,

Zhang³

et al. 2023

Front. Endocrinol.

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Diabetes is a global disease with huge impacts on patients due to its complications, among which non-healing wounds and depression are common and challenging. The neurokinin 1 receptor (NK1R) inhibitor, aprepitant has been broadly applied for an antidepressant effect in depressive patients. Recent literature has indicated a therapeutic effect of downregulation in NK1R to diabetes-related fracture, cardiomyopathy, gastroparesis, and ocular surface disorders. In this study, differential expression genes in diabetes and depression were analyzed based on several RNA sequencing datasets from the GEO database to confirm NK1R in the overlapping set. Interaction network and gene set enrichment analysis were subsequently conducted. As a result, NK1R-related genes took part in angiogenesis, epithelial-mesenchymal transition (EMT), collagen deposition, and inflammation in diabetes and depression. In vivo, the downregulation of NK1R was proved to promote vascular proliferation and enhance diabetic wound healing, which provides a potential therapeutic target for the management of diabetic non-healing wounds and depression.

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Section: Discussionmentioning

confidence: 99%

Potential therapeutic effect of NK1R antagonist in diabetic non-healing wound and depression

Ma²,

Zhang³

et al. 2023

Front. Endocrinol.

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“…RNA was extracted from the treated cells with the manufacturer's instructions (Parstous, Mashhad, Iran). Afterward, a real-time polymerase chain reaction (PCR) was done for samples as described in the previous study [ 23 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

The Anticancer Role of Cerium Oxide Nanoparticles by Inducing Antioxidant Activity in Esophageal Cancer and Cancer Stem-Like ESCC Spheres

Javid

Hashemy

Heidari

et al. 2022

BioMed Research International

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Introduction. Esophagus squamous cell carcinoma (ESCC) has a poor prognosis, a high rate of metastasis, and rapid clinical progression. One hypothesis is that therapeutic failure is due to the presence of cancer stem cells (CSC). Previous studies showed the anticancer effect of cerium oxide nanoparticles (CNP) in different cancer cells. In this study, we aim to evaluate the effect of cerium oxide nanoparticles on cell antioxidants, toxicity, as well as cell oxidant level in esophageal cancer (YM1) and cancer stem cell-like (CSC-LC) cell lines. Method. YM1 and CSC-LC spheres were treated with CNP at different concentrations. The cell viability was assessed by using the MTT test. Antioxidant levels (SOD (superoxide dismutase, CAT (catalase), thiol, and TAC (total antioxidant capacity)), antioxidant genes expression (SOD and CAT), ROS (reactive oxygen species), and MDA (malondialdehyde) levels were assessed in both cell lines. Results. CSC-LC had significantly elevated SOX4 and OCT4 pluripotent genes. The ROS and MDA levels were significantly reduced in both YM1 and CSC-LC spheres after treatment with CNP. Also, the antioxidant levels and expressions were elevated significantly in both cell lines after CNP treatment. Conclusion. These results suggest the potential anticancer effect of CNP by elevating antioxidant levels and expressions, and reducing oxidant levels.

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“…Sensory nerves have been shown to be present in a several cancers, including cervical cancer, melanoma, gastric cancer, pancreatic cancer as well as basal cell carcinoma, where they can influence tumor angiogenesis through various mechanisms. Sensory nerves that travel alongside blood vessels promote angiogenesis via substance P-mediated signaling during inflammation and through its promotion of VEGF and MMP-9 expression in cancer cells ( 240 , 266 , 267 ). Sensory neuropeptides, CGRP and substance P, are also involved in the transcriptional upregulation of several angiogenic markers (VEGF, angiopoietin-2, type 4 collagen, MMP-2) in ECs ( 268 , 269 ).…”

Section: The Nervous Tissue Within the Tumor Microenvironmentmentioning

confidence: 99%

Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment

Shalabi,

Belayachi,

Larrivée

2024

Front. Immunol.

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Emerging evidence suggests that nerves within the tumor microenvironment play a crucial role in regulating angiogenesis. Neurotransmitters and neuropeptides released by nerves can interact with nearby blood vessels and tumor cells, influencing their behavior and modulating the angiogenic response. Moreover, nerve-derived signals may activate signaling pathways that enhance the production of pro-angiogenic factors within the tumor microenvironment, further supporting blood vessel growth around tumors. The intricate network of communication between neural constituents and the vascular system accentuates the potential of therapeutically targeting neural-mediated pathways as an innovative strategy to modulate tumor angiogenesis and, consequently, neoplastic proliferation. Hereby, we review studies that evaluate the precise molecular interplay and the potential clinical ramifications of manipulating neural elements for the purpose of anti-angiogenic therapeutics within the scope of cancer treatment.

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The effect of substance P and its specific antagonist (aprepitant) on the expression of MMP-2, MMP-9, VEGF, and VEGFR in ovarian cancer cells

Cited by 11 publications

References 40 publications

Potential therapeutic effect of NK1R antagonist in diabetic non-healing wound and depression

Potential therapeutic effect of NK1R antagonist in diabetic non-healing wound and depression

The Anticancer Role of Cerium Oxide Nanoparticles by Inducing Antioxidant Activity in Esophageal Cancer and Cancer Stem-Like ESCC Spheres

Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment

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