“…Assays for motility-regulating peptides were conducted with plasma samples of fasted mice, as intestinal transit was examined in similarly conditioned animals. SP, which is known to increase intestinal transit (Liljedahl et al, 1958), was lower in the plasma of PCSK2-KO mice (Fig. 3A); whereas GLP-1, GLP-2 and SS, which are known to slow this transit (Bozkurt et al, 2002;Efendic and Mattsson, 1978), were higher (Fig.…”