The Effect of Substance P on Intestinal Motility in Man

PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides

“…Assays for motility-regulating peptides were conducted with plasma samples of fasted mice, as intestinal transit was examined in similarly conditioned animals. SP, which is known to increase intestinal transit (Liljedahl et al, 1958), was lower in the plasma of PCSK2-KO mice (Fig. 3A); whereas GLP-1, GLP-2 and SS, which are known to slow this transit (Bozkurt et al, 2002;Efendic and Mattsson, 1978), were higher (Fig.…”

Pharmacologically Active Substances of Mammalian Origin

“…In man a marked increase in the segmental and peristaltic movements of the small intestine was obtained following intravenous infusion of substance P in doses as low as 50 units/min. (146). Moreover, Ehrenpreis & Pernow (57) found low concentrations of substance P in the inactive, aganglionic part of the gut in Hirschsprung's disease and abnormally large amounts in the hyperactive gut above this point.…”

“…!) was sufficient to bring about a bright red flush in the head immediately following the start of the infusion (56b, 146 ), and in dogs intravenous doses of substance P as low as 0.2 to 0.5 unit/kg. were capable of producing a fall of blood pressure of 40 to 60 mm.…”

Chronic Diarrhea in an Adult With Hypokalemic Nephropathy and Osteomalacia Due to a Functioning Ganglioneuroblastoma

“…A role in the regulation of gut motility has been inferred for one of the peptide tissue hormones (substance P). 41,42,43 The possibility that the smooth muscle active substance extracted from the tumor in this case represents one of the peptide tissue hormones suggests a possible relationship between turnor secretion and disturbance of gut motility.…”