The effect of substance misuse on HIV persistence in the CNS

LuPone, Teresa; Van Duyne, Rachel; O'Brien, Erick V.; Matt, Stephanie M.; Dampier, Will; Nonnemacher, Michael R.; Wigdahl, Brian; Gaskill, Peter J.; Klase, Zachary

doi:10.1016/b978-0-323-99744-7.00022-5

HIV-Associated Neurocognitive Disorders 2024

DOI: 10.1016/b978-0-323-99744-7.00022-5

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The effect of substance misuse on HIV persistence in the CNS

Teresa LuPone,

Rachel Van Duyne,

Erick V. O'Brien

et al.

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2024

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Cited by 1 publication

References 481 publications

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Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation

Buck,

Xie,

Willis

et al. 2024

Commun Biol

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Substance use disorders (SUDs) are highly comorbid with HIV infection, necessitating an understanding of the interactive effects of drug exposure and HIV. The relationship between HIV infection and cocaine use disorder is likely bidirectional, with cocaine use directly impacting immune function while HIV infection alters addiction-related behavior. To better characterize the neurobehavioral and immune consequences of HIV infection and cocaine exposure, this study utilizes a humanized mouse model to investigate the outcomes of HIV-1 infection on cocaine-related behaviors in a conditioned place preference (CPP) model, and the interactive effects of cocaine and HIV infection on peripheral and central nervous system inflammation. HIV infection selectively impairs cocaine CPP extinction without effecting reinstatement or cocaine seeking under conflict. Behavioral alterations are accompanied by immune changes in HIV infected mice, including increased prefrontal cortex astrocyte immunoreactivity and brain-region specific effects on microglia number and reactivity. Peripheral immune system changes are observed in human cytokines, including HIV-induced reductions in human TNFα, and cocaine and HIV interactions on GM-CSF levels. Together these data provide new insights into the unique neurobehavioral outcomes of HIV infection and cocaine exposure and how they interact to effect immune responses.

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Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation

Buck,

Xie,

Willis

et al. 2024

Commun Biol

View full text Add to dashboard Cite

show abstract

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The effect of substance misuse on HIV persistence in the CNS

Cited by 1 publication

References 481 publications

Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation

Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation

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