The effect of storage solutions on endothelial function and saphenous vein graft patency

Bouhout, Ismail; Ali, Walid Ben; Perrault, Louis P.

doi:10.1007/s12055-018-0720-5

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…EVH has emerged as minimally invasive technique that reduces wound pain and infection in CABG surgery. In a histological and immunohistochemical evaluation of SVG, EVH showed superiority in endothelial layer preservation when compared to OVH [10] . We take EVH as a step for MIDCAB.…”

Section: Discussionmentioning

confidence: 92%

Effect of Endoscopic Versus Open Saphenous Vein Harvesting Technique on Leg Wound Complications

Mubarak¹

2020

Preprint

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Background: EVH has become prevalent in recent years due to its reduced morbidity and increased patient satisfaction. We designed and carried out a prospective study of patients undergoing CABG to compare outcomes of open versus endoscopic harvesting technique for great saphenous vein. Two groups of patients who underwent elective Coronary artery bypass grafting at our hospitals between January 2018 and October 2020 were included. Endoscopic vein harvesting group (50 patients) was performed endoscopic technique compared with Open Vein Harvesting group (50 patients) was performed open surgical incision for harvesting. Both groups were demographically similar and received identical management. Leg wound was evaluated at discharge, 2 weeks, and 4 weeks for evidence of complications. Early outcomes were compared included, infection, gaped wound and re-suture, pain, satisfied cosmetically and mobilization. Results: Endoscopic vein harvesting group had increased harvest time and decreased incision closure time when compared with Open Vein Harvesting. The average hospitalization time was 6.5 ± 2.2 days for Endoscopic vein harvesting group and 9.2 ± 2.9 days for Open Vein Harvesting group. In Endoscopic vein harvesting group, no significant hematomas were observed. In Open Vein Harvesting group, hematomas were detected in 2 patients and were surgically evacuated. In Endoscopic vein harvesting group, edema occurred less frequently. Infection of the incision location did not occur in Endoscopic vein harvesting group. Leg wound complications were significantly reduced in Endoscopic vein harvesting group in comparison with Open Vein Harvesting group. Conclusions: Endoscopic vein harvesting decreases leg wound complications and increases patient’s satisfaction cosmetically.

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Section: Discussionmentioning

confidence: 92%

Effect of Endoscopic Versus Open Saphenous Vein Harvesting Technique on Leg Wound Complications

Mubarak¹

2020

Preprint

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“…There is widespread general acceptance of EVH, doubts about its impact on the integrity, quality of the conduit, and long-term graft patency [Kalra 2016]. In a histological and immunohistochemical evaluation of SVG, EVH showed superiority in endothelial layer preservation, when compared with OVH [Bouhout 2018]. We did not perform histological examination or vein endoscopy after EVH or coronary angiography during follow-up period, only TTFM was done during surgery.…”

Section: E608mentioning

confidence: 99%

Leg Wound Complications: A Comparison Between Endoscopic and Open Saphenous Vein Harvesting Techniques

Mubarak

Abdeljawad

2021

HSF

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Background: The most common conduit for coronary artery bypass graft (CABG) surgery is saphenous vein graft (SVG). There are two techniques for SVG harvesting: open and endoscopic. Our aim is to evaluate clinical results of endoscopic versus open SVG harvesting. Nowadays, endoscopic vein harvesting (EVH) has become prevalent because of reduced complications with more patient satisfaction. Objective: We designed and performed a prospective randomized cohort study of patients undergoing CABG to compare the results of open versus endoscopic harvesting technique. Methods: Patients who underwent elective CABG at our hospitals were divided into two groups, during the period of January 2019 to March 2021. The EVH group (50 patients) underwent endoscopic technique compared with the open vein harvesting (OVH) group (50 patients) that was underwent open surgical incision for great saphenous vein (GSV) harvesting. The two groups demographically were similar and received identical management. Leg wound was evaluated at discharge, two weeks, and four weeks for evidence of any complications. Early outcomes were recorded, including infection, gaped wound and surgical re-suture, degree of pain, level of cosmetic satisfaction, and early mobilization. Results: In the EVH group, harvesting time increased, and incision closure time decreased in comparison with OVH. The hospital stay was 5.5 ± 2.4 days in the EVH group versus 9.5 ± 2.7 days in the OVH group. Leg wound complications were significantly reduced in the EVH group in comparison with the OVH group. Conclusions: Endoscopic vein harvesting technique reduced leg wound complications. Conveniently, patients also were cosmetically satisfied.

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The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease

Ladak

McQueen

Layton

et al. 2022

Cells

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Endothelial cells comprise the intimal layer of the vasculature, playing a crucial role in facilitating and regulating aspects such nutrient transport, vascular homeostasis, and inflammatory response. Given the importance of these cells in maintaining a healthy haemodynamic environment, dysfunction of the endothelium is central to a host of vascular diseases and is a key predictor of cardiovascular risk. Of note, endothelial dysfunction is believed to be a key driver for vein graft disease—a pathology in which vein grafts utilised in coronary artery bypass graft surgery develop intimal hyperplasia and accelerated atherosclerosis, resulting in poor long-term patency rates. Activation and denudation of the endothelium following surgical trauma and implantation of the graft encourage a host of immune, inflammatory, and cellular differentiation responses that risk driving the graft to failure. This review aims to provide an overview of the current working knowledge regarding the role of endothelial cells in the onset, development, and modulation of vein graft disease, as well as addressing current surgical and medical management approaches which aim to beneficially modulate endothelial function and improve patient outcomes.

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The effect of storage solutions on endothelial function and saphenous vein graft patency

Cited by 4 publications

References 44 publications

Effect of Endoscopic Versus Open Saphenous Vein Harvesting Technique on Leg Wound Complications

Effect of Endoscopic Versus Open Saphenous Vein Harvesting Technique on Leg Wound Complications

Leg Wound Complications: A Comparison Between Endoscopic and Open Saphenous Vein Harvesting Techniques

The Role of Endothelial Cells in the Onset, Development and Modulation of Vein Graft Disease

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