The effect of storage on levels of cholesterol in serum as measured by a simple, direct method

Grafnetter, D; Fodor, J. G.; Teplý, V.; Z̆áček, K.

doi:10.1016/0009-8981(67)90266-5

Cited by 31 publications

(6 citation statements)

References 5 publications

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“…"Free nicotinic acid" (CARLSON 1966) in the plasma and total nicotinic acid compounds in the plasma and blood were determined as described above. Plasma cholesterol was analyzed in the "fasted" animals according to GRAFNETTER et al (1967).…”

Section: Methodsmentioning

confidence: 99%

Plasma Levels of Nicotinic Acid Compounds in Niceritrol ^*‐Treated Rabbits

Brattsand

Harthon

1975

Acta Pharmacologica et Toxicologica

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Some pharmacokinetic properties of nicotinic acid (NA) and niceritrol (pentaerythritoltetranicotinate) were investigated in rabbits. Niceritrol released NA at a faster rate on incubation in vitro with plasma or liver homogenate than in a pure buffer solution, indicating that niceritrol was actively hydrolyzed. After administration of niceritrol to rabbits no niceritrol was present in the plasma but metabolites, probably lower esters of niceritrol, free NA and nicotinamide were found. On oral administration of NA in a dose of 16 mg/kg higher maximal plasma levels of free NA (~6 μg/ml) were noted than after adminstration of niceritrol (1.4 μg/ml) in the same dose. A diet producing hyperlipaemia and containing 0.5% niceritrol elevated the levels of free NA in the plasma by about 2 μg/ml. It also reduced the increase in plasma cholesterol. The investigation suggests that the pharmacological and pharmacokinetic properties of niceritrol in the rabbit are similar to those in man.

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Section: Methodsmentioning

confidence: 99%

Plasma Levels of Nicotinic Acid Compounds in Niceritrol ^*‐Treated Rabbits

Brattsand

Harthon

1975

Acta Pharmacologica et Toxicologica

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“…Body weight was checked regularly. Blood samples for serum cholesterol determination were taken in the fasting state from an ear vein and analyzed for cholesterol as described by Grafnetter et al (1967). Different serum lipoprotein (VLDL, LDL and HDL) fractions were isolated with ultra centrifugation (Hatch and Lees, 1968).…”

Section: Methodsmentioning

confidence: 99%

Cholesterol Transfer and Content in Aortic Regions with Defined Endothelial Integrity from Rabbits with Moderate Hypercholesterolemia

Bondjers¹,

Brattsand²,

Hansson³

et al. 1976

Ann Nutr Metab

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To investigate the effect of hypercholesterolemia on cholesterol transfer and retention in the arterial wall in relationship to the endothelial cell layer, moderate hypercholesterolemia was induced in rabbits by the addition of 0.1–0.3% cholesterol in the diet. In arterial tissue with intact endothelium, hypercholesterolemia up to 400 mg% did not affect free cholesterol levels. As the uptake of free cholesterol increased in parallel to serum cholesterol, the elimination of cholesterol must also have increased. In segments with defective endothelium, the free cholesterol content increased in proportion to serum cholesterol, indicating that the potential to maintain constant free cholesterol levels was related to endothelial integrity. Tissue cholesteryl ester increased with increasing serum cholesterol regardless of endothelial integrity. However, the increase was more rapid in tissue underlying defective endothelium, suggesting that also for cholesteryl ester the intact arterial endothelium constitutes an important barrier for influx and retention.

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“…The indications for coronary angiography were either diagnostic or therapeutic. Biochemical examinations included the assessment of total [9] or a-cholestcrol [7] levels, triglyceride levels [10] and lipoprotein electrophoresis [16] beside other current examinations which arc necessary to exclude a secondary origin of the disturbance (diabetes, diseases of the liver and kidneys) [7]. With regard to the criteria of Beaumont el al.…”

Section: Methodsmentioning

confidence: 99%

Analysis of Lipid Disturbances in Patients with Angiographically Confirmed Coronary Artery Disease

Válek¹,

Grafnetter²,

Fabián³

et al. 1974

Ann Nutr Metab

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An analysis of the dependence of weight index (WI), cholesterol, triglyceride levels or lipoprotein phenotypes on the extent of coronary artery lesions was carried out in 90 patients with angiographically established coronary artery disease. Close relationships were revealed between cholesterol levels and atherosclerotic lesions as well as an enhanced incidence of lesions in types II and IV of hyperliproteinaemia. No relationships could be detected between the Wl, triglyceride levels, and atherosclerosis. Conclusions are drawn as to the time of prophylaxis onset in types II and IV hyperlipoproteinaemic subjects and its main direction.

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The effect of storage on levels of cholesterol in serum as measured by a simple, direct method

Cited by 31 publications

References 5 publications

Plasma Levels of Nicotinic Acid Compounds in Niceritrol ^*‐Treated Rabbits

Plasma Levels of Nicotinic Acid Compounds in Niceritrol ^*‐Treated Rabbits

Cholesterol Transfer and Content in Aortic Regions with Defined Endothelial Integrity from Rabbits with Moderate Hypercholesterolemia

Analysis of Lipid Disturbances in Patients with Angiographically Confirmed Coronary Artery Disease

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The effect of storage on levels of cholesterol in serum as measured by a simple, direct method

Cited by 31 publications

References 5 publications

Plasma Levels of Nicotinic Acid Compounds in Niceritrol *‐Treated Rabbits

Plasma Levels of Nicotinic Acid Compounds in Niceritrol *‐Treated Rabbits

Cholesterol Transfer and Content in Aortic Regions with Defined Endothelial Integrity from Rabbits with Moderate Hypercholesterolemia

Analysis of Lipid Disturbances in Patients with Angiographically Confirmed Coronary Artery Disease

Contact Info

Product

Resources

About

Plasma Levels of Nicotinic Acid Compounds in Niceritrol ^*‐Treated Rabbits

Plasma Levels of Nicotinic Acid Compounds in Niceritrol ^*‐Treated Rabbits