The effect of stimulation of the reticulo-hypothalamic-hippocampal systems on the cerebral blood flow and neocortical and hippocampal electrical activity in cats

Królicki, Leszek; Chodobski, Adam; Skolasińska, K

doi:10.1007/bf00236941

Cited by 12 publications

(6 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The perifornical‐lateral hypothalamic area (PF‐LHA) has been implicated in the regulation of behavioral arousal (McGinty & Szymusiak, 2003; Gerashchenko & Shiromani, 2004; Jones, 2005). Electrical stimulation of the PF‐LHA evokes locomotor activity and electroencephalogram (EEG) activation, and most of the neurons within the PF‐LHA exhibit wake‐related discharge activity (Krolicki et al. , 1985; Sinnamon et al.…”

Section: Introductionmentioning

confidence: 99%

“…The perifornical-lateral hypothalamic area (PF-LHA) has been implicated in the regulation of behavioral arousal (McGinty & Szymusiak, 2003;Gerashchenko & Shiromani, 2004;Jones, 2005). Electrical stimulation of the PF-LHA evokes locomotor activity and electroencephalogram (EEG) activation, and most of the neurons within the PF-LHA exhibit wake-related discharge activity (Krolicki et al, 1985;Sinnamon et al, 1999;Alam et al, 2002;Koyama et al, 2003). The PF-LHA contains several cell types including those expressing hypocretin (HCRT) and melanin-concentrating hormone (MCH) peptides (Broberger et al, 1998;Peyron et al, 1998;Abrahamson & Moore, 2001).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of serotonin on perifornical‐lateral hypothalamic area neurons in rat

Kumar

Szymusiak

Bashir³

et al. 2007

Eur J of Neuroscience

View full text Add to dashboard Cite

The hypocretin (HCRT) system of the perifornical-lateral hypothalamic area (PF-LHA) has been implicated in the facilitation of behavioral arousal. HCRT neurons receive serotonergic afferents from the dorsal raphe nucleus. Although in-vitro pharmacological studies suggest that serotonin (5-HT) inhibits HCRT neurons, the in-vivo effects of 5-HT on HCRT neurons in the PF-LHA and associated behavioral changes have not been described. We examined the effects of 5-HT delivered locally into the PF-LHA using reverse microdialysis on its neuronal activity and the consequent sleep-wake changes in rats. First, we quantified Fos expression (Fos-IR) in HCRT and other PF-LHA neurons following unilateral 5-HT perfusion in awake rats. Second, we determined the transient effects of 5-HT perfusion on the extracellular activity of the PF-LHA neurons recorded via microwires placed adjacent to the microdialysis probe. Third, we examined the effects of 5-HT perfusion into the PF-LHA on the sleep-wake profiles of the rats during the lights-off period. Unilateral perfusion of 5-HT into the PF-LHA in awake rats dose-dependently decreased the number of HCRT neurons exhibiting Fos-IR. 5-HT also inhibited the discharge activity of four of five responsive wake-related, putative HCRT neurons. However, unilateral perfusion of 5-HT into the PF-LHA did not produce significant behavioral changes during the 2-h recording period. These results confirm the in-vitro findings that 5-HT exerts inhibitory influences on HCRT neurons but further suggest that the inactivation of a limited number of HCRT neurons by unilateral 5-HT microdialysis may not be sufficient to induce behavioral changes.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of serotonin on perifornical‐lateral hypothalamic area neurons in rat

Kumar

Szymusiak

Bashir³

et al. 2007

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Electrical stimulation of the PeF area evokes locomotor activity and electroencephalogram (EEG) activation as well as autonomic effects such as higher blood pressure and heart rate (Stock et al. , 1981; Krolicki et al. , 1985; Sinnamon et al.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the perifornical hypothalamic area and oral pontine reticular nucleus in the rat. Possible implication of the hypocretinergic projection in the control of rapid eye movement sleep

Núñez

Moreno‐Balandrán

Rodrigo-Angulo

et al. 2006

Eur J of Neuroscience

View full text Add to dashboard Cite

The perifornical (PeF) area in the posterior lateral hypothalamus has been implicated in several physiological functions including the regulation of sleep-wakefulness. Some PeF neurons, which contain hypocretin, have been suggested to play an important role in sleep-wake regulation. The aim of the present study was to examine the effect of the PeF area and hypocretin on the electrophysiological activity of neurons of the oral pontine reticular nucleus (PnO), which is an important structure in the generation and maintenance of rapid eye movement sleep. PnO neurons were recorded in urethane-anesthetized rats. Extracellular recordings were performed by means of tungsten microelectrodes or barrel micropipettes. Electrical stimulation of the ipsilateral PeF area elicited orthodromic responses in both type I (49%) and type II (58%) electrophysiologically characterized PnO neurons, with a mean latency of 13.0 +/- 2 and 8.3 +/- 5 ms, respectively. In six cases, antidromic spikes were evoked in type I PnO neurons with a mean latency of 3.2 +/- 0.4 ms, indicating the existence of PnO neurons that projected to the PeF area. Anatomical studies showed retrogradely labeled neurons in the PeF area from the PnO. Some of these neurons projecting to the PnO contained hypocretin (17.8%). Iontophoretic application of hypocretin-1 through a barrel micropipette in the PnO induced an inhibition, which was blocked by a previous iontophoretic application of bicuculline, indicating that the inhibitory action of hypocretin-1 may be due to activation of GABA(A) receptors. These data suggest that the PeF area may control the generation of rapid eye movement sleep through a hypocretinergic projection by inhibiting the activity of PnO neurons.

show abstract

“…The perifornical‐lateral hypothalamic area (PF‐LHA) has been implicated in several physiological functions including the regulation of locomotor activity and behavioural arousal. Electrical stimulation of the PF‐LHA evokes locomotor activity, EEG activation, increased blood pressure and increased heart rate (Stock et al 1981; Krolicki et al 1985; Sinnamon et al 1999). A majority of neurones within PF‐LHA are active during waking and exhibit little activity during non‐rapid eye movement (non‐REM) sleep (Alam et al 2002; Koyama et al 2003).…”

mentioning

confidence: 99%

GABA‐mediated control of hypocretin‐ but not melanin‐concentrating hormone‐immunoreactive neurones during sleep in rats

Alam

Kumar

Bashir

et al. 2005

The Journal of Physiology

113

View full text Add to dashboard Cite

The perifornical-lateral hypothalamic area (PF-LHA) has been implicated in the regulation of behavioural arousal. The PF-LHA contains several cell types including neurones expressing the peptides, hypocretin (HCRT; also called orexin) and melanin-concentrating hormone (MCH). Evidence suggests that most of the PF-LHA neurones, including HCRT neurones, are active during waking and quiescent during non-rapid eye movement (non-NREM) sleep. The PF-LHA contains local GABAergic interneurones and also receives GABAergic inputs from sleep-promoting regions in the preoptic area of the hypothalamus. We hypothesized that increased GABA-mediated inhibition within PF-LHA contributes to the suppression of neuronal activity during non-REM sleep. EEG and EMG activity of rats were monitored for 2 h during microdialytic delivery of artificial cerebrospinal fluid (aCSF) or bicuculline, a GABA A receptor antagonist, into the PF-LHA in spontaneously sleeping rats during the lights-on period. At the end of aCSF or bicuculline perfusion, rats were killed and c-Fos immunoreactivity (Fos-IR) in HCRT, MCH and other PF-LHA neurones was quantified. In response to bicuculline perfusion into the PF-LHA, rats exhibited a dose-dependent decrease in non-REM and REM sleep time and an increase in time awake. The number of HCRT, MCH and non-HCRT/non-MCH neurones exhibiting Fos-IR adjacent to the microdialysis probe also increased dose-dependently in response to bicuculline. However, significantly fewer MCH neurones exhibited Fos-IR in response to bicuculline as compared to HCRT and other PF-LHA neurones. These results support the hypothesis that PF-LHA neurones, including HCRT neurones, are subject to increased endogenous GABAergic inhibition during sleep. In contrast, MCH neurones appear to be subject to weaker GABAergic control during sleep.

show abstract

The effect of stimulation of the reticulo-hypothalamic-hippocampal systems on the cerebral blood flow and neocortical and hippocampal electrical activity in cats

Cited by 12 publications

References 32 publications

Effects of serotonin on perifornical‐lateral hypothalamic area neurons in rat

Effects of serotonin on perifornical‐lateral hypothalamic area neurons in rat

Relationship between the perifornical hypothalamic area and oral pontine reticular nucleus in the rat. Possible implication of the hypocretinergic projection in the control of rapid eye movement sleep

GABA‐mediated control of hypocretin‐ but not melanin‐concentrating hormone‐immunoreactive neurones during sleep in rats

Contact Info

Product

Resources

About