The Effect of Stevia Rebaudiana on Serum Omentin and Visfatin Level in STZ-Induced Diabetic Rats

Akbarzadeh, Samad; Eskandari, Fatemeh; Tangestani, Hadith; Bagherinejad, Somaieh Tangerami; Bargahi, Afshar; Bazzi, Parviz; Daneshi, Adel; Sahrapoor, Azam; O’Connor, William; Rahbar, Alireza

doi:10.3109/19390211.2014.901999

Cited by 29 publications

(31 citation statements)

References 31 publications

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“…Previous reports on thyroid function in diabetic rats were inconsistent and there was no intensive exploration of HPT axis function. Our results showed significantly lower T3 and T4 levels in diabetic group than those in NC group, which was consistent with previous results [ 18 – 21 ]. We also detected no significant difference on the levels of TSH and pro-TRH mRNA between normal and DM group, which were in line with results of Nascimento-Saba et al [ 20 ] and Derkach et al [ 22 ].…”

Section: Discussionsupporting

confidence: 93%

“…We also detected no significant difference on the levels of TSH and pro-TRH mRNA between normal and DM group, which were in line with results of Nascimento-Saba et al [ 20 ] and Derkach et al [ 22 ]. However, Akbarzadeh et al detected that TSH in diabetic rats induced by 55 mg/kg STZ was even higher than that of NC group [ 18 ], and similar result was proved in other studies using low-dose STZ (30–40 mg/kg) to induce mild diabetic model [ 22 , 23 ]. The discrepancies might be related to the dose and manner of STZ administration in diabetes model.…”

Section: Discussionsupporting

confidence: 56%

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Jinlida Granules Improve Dysfunction of Hypothalamic-Pituitary-Thyroid Axis in Diabetic Rats Induced by STZ

Wang

Dai

Zhang

et al. 2018

BioMed Research International

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Objective We aim to explore the effects and mechanisms of Jinlida granules on the dysfunction of hypothalamic-pituitary-thyroid (HPT) axis in diabetic rats induced by streptozotocin. Methods A total of 48 SD rats were randomized into normal control group (NC, n = 6) and diabetic group (n = 42). Rats in diabetic group were randomly divided into diabetes mellitus (DM) control group, low, medium, and high doses of Jinlida group (JL, JM, and JH), medium dose of Jinlida plus Tongxinluo group (JM + T), metformin group (Met), and Saxagliptin group (Sax) (n = 6 in each group). Diabetic rats were obtained by intraperitoneal injection of streptozotocin and sacrificed at 8 weeks to examine the function of HPT axis. Results Levels of fasting blood glucose (P < 0.05), pIκB, TNFα (P < 0.05), pNF-κB, and IL-6 (P < 0.01) in liver tissue and TSHR mRNA expression (P < 0.01) in diabetic group were significantly increased, while levels of serum T3 and T4, thyroid hormone receptor (TR) mRNA and Dio1 mRNA in liver tissue, and sodium iodide symporter (NIS) mRNA in thyroid tissue in diabetic group were significantly decreased compared with those in NC group (P < 0.01). Among diabetic groups, level of fasting blood glucose in JH, JM + T and Met group was lower (P < 0.05) compared with DM group. However, levels of serum T3 and T4, TR mRNA in liver tissue, TSHR, and NIS mRNA in thyroid tissue in JH, JM + T, Met, and Sax group were significantly increased (P < 0.01) compared to DM group. In contrast, levels of Dio1 mRNA, pI-κB in Met and JM + T groups, pNF-κB in JH, JM + T, and Met group, and TNFα and IL-6 in JM, JH, JM + T, and Met group were significantly decreased (P < 0.05). HE staining showed reduced thyroid follicular epithelium and follicular area, as well as increased colloid area in DM group, indicating impaired synthesis, reabsorption, and secretory of TH in diabetes, which was significantly improved in JH, JM + T, and Met groups. Conclusion HPT axis dysfunction in DM could be significantly improved by Jinlida granules. The mechanism might be associated with the anti-inflammatory effects involving NF-κB pathway. Our findings suggested the potential benefit of Jinlida granules for patients with HPT axis dysfunction and DM, which was to be verified by more experimental and clinical studies.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 56%

Jinlida Granules Improve Dysfunction of Hypothalamic-Pituitary-Thyroid Axis in Diabetic Rats Induced by STZ

Wang

Dai

Zhang

et al. 2018

BioMed Research International

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“…Chemical composition: The chemical composition of Stevia rebaudiana Bertoni leaves powder indicated that moisture, crude protein, crude fat, crude fiber, crude ash and carbohydrates were 9.7 ± 0.04 %, 10.23 ± 0.07 %, 14.87 ± 0.10 %, 4.15 ± 0.16 %, 9.65 ± 0.19 % and 51.4 ± 0.32 % respectively ( Table 1). The results are in accordance with the studies of [7,21] who stated that moisture, ash, protein, fat, fiber and carbohydrates in Stevia rebaudiana Bertoni dried leaves powder were in the ranges of 7.35-10.73%, 12.06-13.12%, 13.68-16.92%, 0.5-6.13%, 5.03-10.12% and 57.59-63.1% respectively.…”

Section: Characterization Of Stevia Leaves Powdersupporting

confidence: 92%

“…The carbohydrates in stevia leaves powder muffins decreased as compared to control because stevia contained zero calories. The fat content in functional muffins increased than control but the difference was not pronounced because stevia has less amount of fat content as recorded in the previous literature [7,21]. T 0 = 100% sucrose T 1 = 25% stevia leaves powder: 75 % sucrose T 2 = 50% stevia leaves powder: 50 % sucrose T 3 = 75% stevia leaves powder: 25 % sucrose T 4 = 100% stevia leaves powder Where 1g of stevia leaves powder= 20 g of sucrose T 0 = 100% sucrose T 1 = 25 % stevia leaves powder: 75% sucrose T 2 = 50 % stevia leaves powder: 50% sucrose T 3 = 75 % stevia leaves powder: 25% sucrose T 4 = 100 % stevia leaves powder Where 1g of stevia leaves powder=20 g of sucrose with mean values as (120.02 ± 0.77-1300.03 ± 0.80 ppm), (90.05 ± 0.60-660.04 ± 0.88 ppm), (32.10 ± 0.54-250.03 ± 0.82 ppm), (21.11 ± 0.27-180.04 ± 0.77 ppm) and (2.00 ± 0.03-11.07 ± 0.08 ppm) respectively.…”

Section: Chemical Analysis Of Functional Muffinsmentioning

confidence: 52%

Nutritional, Physicochemical and Organoleptic Evaluation of Low Calorie Muffins Using Natural Sweetener Stevia (Stevia rebaudiana Bertoni)

Ahmad¹,

Ahmad²

2018

J Nutr Food Sci

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Stevia (Stevia rebaudiana Bertoni) natural, safe, non-toxic, non-caloric sugar substitute can be used in the preparation of different food products for diabetes and weight maintaining approaches. In the current study, low calorie muffins were prepared by the substitution of dried stevia leaves powder with sucrose at different levels (25:75, 50:50, 75:25 and 100:0%) as sugar substitute and investigated their nutritional, physicochemical and organoleptic properties. The results demonstrated that stevia is rich source of crude protein (14.87 ± 0.10%), fiber (9.65 ± 0.19 %), K (22000 ± 96.65 ppm), Ca (13300 ± 74.22 ppm), Mg (4500 ± 32.22 ppm), P (3200 ± 23.12 ppm), total phenols (20.3 ± 0.15 (mg GAE/g), total flavonoids (14.32 ± 0.09 mg Catechin/g) and has strong DPPH activity (58.24 ± 0.30 mg Trolox/g). Addition of stevia leaves powder significantly increased the nutritional profile (chemical, mineral and antioxidant properties) of stevia muffins except carbohydrates from T 1 to T 4. Furthermore, stevia leaves powder notably affected the physicochemical (diameter, thickness, spread factor, firmness, springiness and color) and organoleptic parameters (color, flavor, texture, taste, appearances and overall acceptability) of all the treatments. Muffins with 25:75% (stevia: sucrose) were most liked by judges. Conclusively, stevia could be used as natural sweetener in food products.

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“…According to Akbarzadeh et al . (), an increase in omentin serum was observed in rats with experimental diabetes induced by STZ. Nevertheless, the exact role of omentin is not well described in the literature.…”

Section: Discussionmentioning

confidence: 85%

Experimental type 2 diabetes induction reduces serum vaspin, but not serum omentin, in Wistar rats

Castro

Silva

Buffo

et al. 2017

Int J Experimental Path

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Vaspin and omentin are adipose tissue adipokines that have often been related to obesity and its comorbidities. The aim of this study was to investigate the behaviour of serum omentin and vaspin in models of type 2 diabetes. To do this, Wistar rats (~200 g) were randomly divided into two groups: a non-diabetic group (n = 6) and a diabetic group fed on a high-fat diet (n = 6) and a low dose of streptozotocin (Sigma ). All procedures were approved by the Brazilian Ethics Committee. Body weight (BW) and food intake were recorded daily. Tail blood glucose levels were assessed at the end of the diabetes induction period. The insulin tolerance test (ITT) was performed after the diabetes induction period (7 weeks). The serum and tissues (liver, pancreas, and retroperitoneal (RET), epididymal (EPI) and visceral (VIS) white adipose tissues) were immediately removed and weighed. Analyses of levels of insulin, omentin, vaspin, adiponectin and inflammatory cytokines IL-6, IL-8 (CXCL8), TNF-α and C-reactive protein (CRP) in serum were performed using the enzyme-linked immunosorbent assay (ELISA). Our results showed that IL-8 and CRP serum levels in the diabetic group were significantly higher than in the non-diabetic group. Vaspin and adiponectin values were lower for the diabetic group than for the non-diabetic group. Omentin, IL-6 and TNF-α values did not differ between the groups. Our results showed that both the metabolism of the adipose tissue and the secretion of adipokines may be affected in diabetic rats. Omentin showed no difference between the groups, although the vaspin values decreased in the diabetic group.

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The Effect of Stevia Rebaudiana on Serum Omentin and Visfatin Level in STZ-Induced Diabetic Rats

Cited by 29 publications

References 31 publications

Jinlida Granules Improve Dysfunction of Hypothalamic-Pituitary-Thyroid Axis in Diabetic Rats Induced by STZ

Jinlida Granules Improve Dysfunction of Hypothalamic-Pituitary-Thyroid Axis in Diabetic Rats Induced by STZ

Nutritional, Physicochemical and Organoleptic Evaluation of Low Calorie Muffins Using Natural Sweetener Stevia (Stevia rebaudiana Bertoni)

Experimental type 2 diabetes induction reduces serum vaspin, but not serum omentin, in Wistar rats

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