The effect of standard therapy on mean platelet volume in patients with chronic hepatitis C

Uslu, Ali Uğur; Aydın, Bahattin; Balta, Şevket; Yönem, Özlem; Uncu, Tunahan; Seven, D.

doi:10.5114/pg.2016.57942

Cited by 4 publications

(2 citation statements)

References 19 publications

(37 reference statements)

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“…One of the remarkable features of the study was that the mean MPV of each group was significantly higher than the mean MPV of the control group regardless of cirrhosis etiology. This result was consistent with previous studies on chronic liver diseases, in which the increase in MPV value was correlated with inflammation [24][25][26].Also the results of recent studies by Kurt and Qi are compatible with our data [27][28]. In some previous studies, MPV was found to be lower in patients with hypersplenism than in the control group, and this has been shown to cause from spleen's destruction of large volumed platelets by holding them [21,29].…”

Section: Discussionsupporting

confidence: 93%

Evaluation of platelet and mean platelet volume levels in patients with liver cirrhosis

Erdem¹,

Çil

Tükek

et al. 2018

Archives of Clinical and Experimental Medicine

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Liver cirrhosis isa process characterized by fibrosis and normal liver structure is replaced with diffuse nodular structure. Different laboratory values are used for diagnosis and prognosis of liver cirrhosis. To determine platelet and mean platelet volume levels of patients with liver cirrhosis and to find out if platelet or mean platelet volume levels have changed according to Child-Pugh classification or the etiology of cirrhosis. Methods: A total of 201 patients with cirrhosis who have been followed by of an education and research hospital internal medicine outpatient clinic between the years of 2006 and 2013, were included. Platelet count <150,000 / µL was accepted as thrombocytopenia. Individuals with diseases that can cause thrombocytopenia, patients using drugs that can cause thrombocytopenia and who has pseudothrombocytopenia were excluded from the study. Results: The number percantage ratios of patients according to underlying etiology for chronic liver disease were as follows Group 1 (alcoholic liver disease) with rate of % 16.9, Group 2 (hepatitis-B) with rate of % 25.4, Group 3 (hepatitis-C) with rate of % 23.4, Group 4 (cryptogenic) with rate of % 34.3.Average platelet value in the Group 1 was 130.2 ± 74 x 103/ µL, Group 2 was 104.8 ± 56.8 x 103/ µL, Group 3 was 100.6 ± 44.2 x 103/ µL, Group 4 was 104,1 ± 48.7 x 103/ µL;average platelet value in the control group (Group 5) was 247.7

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Section: Discussionsupporting

confidence: 93%

Evaluation of platelet and mean platelet volume levels in patients with liver cirrhosis

Erdem¹,

Çil

Tükek

et al. 2018

Archives of Clinical and Experimental Medicine

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“…Whereas, several studies showed that MPV is decreased in HIV-infected patients 30 , 31 , suggesting impaired platelet production rather than increased destruction. In HCV infection, the status of platelet was closely correlated with degree of fibrosis, platelet counts was decreased while MPV was increased in chronic hepatitis C (CHC) patients, especially in those with advanced fibrosis 32 , 33 .…”

Section: Introductionmentioning

confidence: 99%

HCV coinfection aggravated the decrease of platelet counts, but not mean platelet volume in chronic HIV-infected patients

Fan

et al. 2018

Sci Rep

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Either HIV or HCV monoinfection could result in an abnormal status of platelets. As two key indicators reflecting activation and function of platelets, the changes of platelet counts and mean platelet volume (MPV) in HIV/HCV-coinfected patients have not been clearly identified. In the present study, a total of 318 former plasma donors were investigated in 2006, and 66% (201 individuals) of primary recruiters were followed up in 2014. By horizontal comparison in 2006, the decrease of platelet counts in HIV/HCV coinfection was greater than that in HIV or HCV monoinfection. MPV scores were lower in HIV monoinfection compared with healthy controls, while no difference was found in HIV/HCV coinfection. Platelet counts were shown to be negatively correlated with MPV scores in total recruited population (r = 0.432, P < 0.001). Interestingly, by comparison of data from two time points of 2006 and 2014, significant decrease of platelets (P = 0.004) and increase of MPV (P = 0.004) were found only in HCV monoinfected patients, which may associate with slow progression of hepatic fibrosis induced by chronic HCV infection. Nonetheless, no significant changes of platelet counts and MPV were found from 2006 to 2014 in coinfected patients. In conclusion, HCV coinfection aggravated the decrease of platelet counts, but not MPV score in chronic HIV infection. MPV showed poor applicability in reflecting the status of platelets in HIV/HCV-coinfected patients.

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Can Mean Platelet Volume Indicate Helicobacter Positivity and Severity of Gastric Inflammation? An Original Study and Review of the Literature

Akar

2019

ACC

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Bülent ecevıt unıversity medical faculty, department of gastroenterology, Zonguldak, turkey SummAry -Helicobacter pylori (H. pylori) is a common problem and a significant cause of chronic gastric inflammation. H. pylori, ongoing gastric inflammation and its severity are the most critical component of precursors of gastric cancer. hypothetically, every chronic tissue injury activates platelets, and the mean platelet volume (mPv) reflects this action well. The potential relationship between H. pylori and platelet count has been shown before. however, there are few and conflicting papers about the relationship between mPv and H. pylori related chronic gastric inflammation and its severity. The study aimed to assess any potential relationship between mPv and presence of H. pylori, as well as the severity of chronic gastric inflammation. A total of 6890 endoscopic reports were initially evaluated, and a total of 218 dyspeptic patients having undergone upper endoscopy were included. Of these, 118 (54.2%) were H. pylori positive and 100 (45.8%) were H. pylori negative. At least four gastric biopsies were obtained and evaluated according to Sydney classification. Age, gender, hemoglobin, mean corpuscular volume, ferritin, serum iron and C-reactive protein, as well as endoscopic findings were also recorded. A p<0.05 was accepted as significant. The mPv and platelet count did not differ between H. pylori positive and H. pylori negative groups of patients (p>0.05). There were no differences and correlation between mPv and gastric inflammation severity according to Sydney classification (p>0.05). when stratifying mPv as <9.15 fl and >9.15 fl, there was no difference between H. pylori positive and H. pylori negative groups either (p>0.05). In this study, we found no relationship between mPv and presence of H. pylori or severity of gastric inflammation. Although there are still conflicting publications on this issue, in our opinion and according to the results of this study, mPv is not a suitable marker for evaluation of gastric inflammation severity, being H. pylori either positive or negative.

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The effect of standard therapy on mean platelet volume in patients with chronic hepatitis C

Cited by 4 publications

References 19 publications

Evaluation of platelet and mean platelet volume levels in patients with liver cirrhosis

Evaluation of platelet and mean platelet volume levels in patients with liver cirrhosis

HCV coinfection aggravated the decrease of platelet counts, but not mean platelet volume in chronic HIV-infected patients

Can Mean Platelet Volume Indicate Helicobacter Positivity and Severity of Gastric Inflammation? An Original Study and Review of the Literature

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