The effect of spermine on the initiation of mitochondrial protein synthesis

Christian, Brooke E.; Haque, Md. Emdadul; Spremulli, Linda L.

doi:10.1016/j.bbrc.2009.11.169

Cited by 13 publications

(9 citation statements)

References 27 publications

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“…In a study, it has been found to act as a specific semen-derived sex pheromone in sea lamprey and promotes mating behaviors [ 161 ]. It is also evident to show antiinflammatory [ 162 ], mitochondrial protein synthesis [ 163 ], cardioprotective [ 164 ], and other effects. Lycopsamine exerted protective effects in spinal cord injury in rats by improving functional recovery and suppressing apoptosis [ 165 ].…”

Section: Discussionmentioning

confidence: 99%

Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity

Sarkar

Mondal

Khanom

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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This study aimed to summarize the available data on the ethnomedicinal and phytopharmacological activities of Heliotropium indicum L. based on database reports. For this purpose, an up-to-date literature search was carried out in the Google Scholar, Scopus, Springer Link, Web of Science, ScienceDirect, ResearchGate, PubMed, Chem Spider, Elsevier, BioMed Central, and patent offices (e.g., USPTO, CIPO, NPI, Google patents, and Espacenet) for the published materials. The findings suggest that the plant contains many important phytochemicals, including pyrrolizidine alkaloids, indicine, echinitine, supinine, heleurine, heliotrine, lasiocarpine, acetyl indicine, indicinine, indicine N-oxide, cynoglossine, europine N-oxide, heleurine N-oxide, heliotridine N-oxide, heliotrine N-oxide, heliotrine, volatile oils, triterpenes, amines, and sterols. Scientific reports revealed that the herb showed antioxidant, analgesic, antimicrobial, anticancer, antituberculosis, antiplasmodial, anticataract, antifertility, wound healing, antiinflammatory, antinociceptive, antihyperglycemic, anthelmintic, diuretic, antitussive, antiglaucoma, antiallergic, and larvicidal activity. In conclusion, in vitro studies with animal models seem to show the potential beneficial effects of H. indicum against a wide variety of disorders and as a source of phytotherapeutic compounds. However, clinical studies are necessary to confirm the effects observed in animal models, determine the toxicity of the therapeutic dose and isolate the truly bioactive components.

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Section: Discussionmentioning

confidence: 99%

Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity

Sarkar

Mondal

Khanom

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…10). Spermine, for example, has been shown to regulate synthesis of mitochondrial proteins by stabilizing a small subunit of the ribosome and fMet-tRNA complex (71). Furthermore, recently Choo and Blenis (72) reported that rapamycin inhibited S6K in various cell lines.…”

Section: Discussionmentioning

confidence: 99%

Amino Acids Regulate Expression of Antizyme-1 to Modulate Ornithine Decarboxylase Activity

Ray

Viar

Johnson

2012

Journal of Biological Chemistry

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Background: Amino acids regulate ornithine decarboxylase (ODC) activity through antizyme-1 (AZ1). Results: Asparagine or glutamine prevents AZ1 expression in response to amino acid starvation. AZ1 synthesis by amino acids is regulated by a differential activation of mTORC1/2. Conclusion: The inhibition of mTORC1 and activation of mTORC2 during amino acid starvation induces AZ1 synthesis. Significance: Putrescine and amino acids regulate ODC activity by stimulating AZ1 synthesis via mTORC2.

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“…Perhaps the binding of polyamines to tRNA (36,37) enhances the association of the EF-Tu-GTP-aminoacyl-tRNA complexes with the ribosome. The Tabor lab reported that addition of polyamines to an auxotrophic strain of E. coli enhanced the production of a full-length protein dependent on a nonsense suppressor tRNA (38). Although the simple interpretation of this result is that polyamines are enhancing the utilization of the suppressor tRNA during elongation, additional experiments are needed to determine whether the polyamines are affecting the levels or aminoacylation of the suppressor tRNA.…”

Section: Polyamine Stimulation Of Translation In Vitromentioning

confidence: 99%

Roles of polyamines in translation

Dever

Ivanov

2018

Journal of Biological Chemistry

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Polyamines are organic polycations that bind to a variety of cellular molecules, including nucleic acids. Within cells, polyamines contribute to both the efficiency and fidelity of protein synthesis. In addition to directly acting on the translation apparatus to stimulate protein synthesis, the polyamine spermidine serves as a precursor for the essential post-translational modification of the eukaryotic translation factor 5A (eIF5A), which is required for synthesis of proteins containing problematic amino acid sequence motifs, including polyproline tracts, and for termination of translation. The impact of polyamines on translation is highlighted by autoregulation of the translation of mRNAs encoding key metabolic and regulatory proteins in the polyamine biosynthesis pathway, including S-adenosylmethionine decarboxylase (AdoMetDC), antizyme (OAZ), and antizyme inhibitor 1 (AZIN1). Here, we highlight the roles of polyamines in general translation and also in the translational regulation of polyamine biosynthesis.Because of their cationic properties, polyamines bind to negatively charged molecules in cells. Nucleic acids, including both DNA and RNA, are prominent binding sites for polyamines with nearly 90% of the spermidine in Escherichia coli cells bound to RNA (1). A substantial fraction (ϳ15%) of the polyamines in E. coli are stably associated with ribosomes (2). Polyamines stimulate general protein synthesis and also impact the fidelity of translation. The importance of polyamines to translation is highlighted by the mRNA-specific translational control mechanisms that link polyamine levels to the synthesis of key polyamine biosynthetic enzymes and their regulators. In this Minireview, we will highlight the roles of polyamines in general translation and in the translational regulation of polyamine biosynthesis. In honor of Herb Tabor, we will also highlight his contributions to this area of polyamine research.3 The abbreviations used are: A,

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The effect of spermine on the initiation of mitochondrial protein synthesis

Cited by 13 publications

References 27 publications

Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity

Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity

Amino Acids Regulate Expression of Antizyme-1 to Modulate Ornithine Decarboxylase Activity

Roles of polyamines in translation

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