The Effect of Space Flight Upon Plasma and Tissue Lipids in Rats: The Cosmos Biosatellite Program

Ahlers, I; Tigranyan, R.A.; Ahlersová, E; Paulíková, E; Datelinka, I; Smajda, B; Toropila, M; Praslìcka, M

doi:10.1016/b978-0-08-027340-2.50045-6

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the heart muscle glycogen concentration did not change in MEL rats of both variants A and B, the glycogen concentration increase (variant B vs. A) is the consequence of 48-h fasting in MEL and control rats. Ahlersová et al (1982) reported increased heart muscle glycogen concentration during 6-day fasting in male Wistar:Han rats, indicating the metabolic specificity of this organ. Forty-eight hour fasting reduced liver malondialdehyde concentration; overnight fasting (variant A) increased it to the level of controls, both in males and females.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Effects of Prolonged Melatonin Administration and Short-Term Fasting in Laboratory Rats

Bojková

Marková²,

Ahlersová

et al. 2006

Acta Vet. Brno

Self Cite

View full text Add to dashboard Cite

Bojková B., M. Marková, E. Ahlersová, I. Ahlers, E. Adámeková, P. Kubatka, M. Kassayová: Metabolic Effects of Prolonged Melatonin Administration and Short-Term Fasting in Laboratory Rats. Acta Vet. Brno 2006, 75: 21-32.The aim of this work was to evaluate the effect of prolonged administration of the pineal hormone melatonin and short-term fasting on metabolic variables in male and female Wistar:Han rats. Melatonin (MEL, 4µg/ml of tap water) was administered daily since the 5 th week of age. The control group drank tap water. Rats were fed a standard type of diet ad libitum and were kept in the light regimen L:D -12:12 h. The experiment was terminated after 11 (variant B) or 12 (variant A) weeks of MEL administration. The animals were sacrificed by quick decapitation following overnight fasting (variant A) or 48-h fasting (variant B). Selected organs and tissues were removed and weighed and selected metabolic variables in the serum and tissues were determined.MEL decreased body mass independent of food and water intake in both sexes. In males (variant A) MEL increased the weight of the heart muscle, spleen and adrenals; it decreased the absolute weight of epididymal fat and increased serum corticosterone and phospholipids concentration in comparison with controls. In females, serum glucose decrease and liver triacylglycerols increase were found. After 48-h fasting (variant B) liver, spleen and adrenal weight increase in MELdrinking females was found. In males MEL increased the thymus weight and decreased the epididymal fat weight. In both sexes MEL increased serum corticosterone and liver glycogen concentration; MEL increased serum glucose in males and serum cholesterol concentration in females. Changes in the evaluated variables were also related to fasting duration prior to decapitation.A 48-h fasting at the end of the prolonged MEL intake (variant B vs. A) decreased the absolute liver weight in both sexes and the epididymal/periovarial fat weight, and increased thymus weight in males. In females it decreased the absolute heart muscle weight and increased the spleen weight. In males, 48-h fasting increased serum corticosterone and phospholipids concentration; it decreased the liver triacylglycerols content in females and the liver cholesterol content in males and females. In both sexes 48-h fasting increased glucose concentration in the serum and glycogen concentration in the liver and heart muscle as well as triacylglycerols and cholesterol concentration in the serum, phospholipids concentration in the liver and bone marrow and decreased malondialdehyde concentration in the liver. Forty-eight hour fasting after prolonged MEL administration resulted in a wider range of carbohydrate and lipid metabolism alterations of young rats of both sexes. Melatonin, prolonged administration, metabolic variables, short-term fastingMelatonin (MEL), the main pineal hormone, is a substance of numerous physiological effects. In addition to epiphysis, MEL is synthesized in other tissues too -e.g. in the retina, extraorbi...

show abstract

Section: Discussionmentioning

confidence: 99%

Metabolic Effects of Prolonged Melatonin Administration and Short-Term Fasting in Laboratory Rats

Bojková

Marková²,

Ahlersová

et al. 2006

Acta Vet. Brno

Self Cite

View full text Add to dashboard Cite

show abstract

“…To investigate the effects of spaceflight on the liver, rats were flown aboard several missions, and data collected at landing indicated that nutrient metabolism in the liver was altered during flight. For example, Ahlers et al (4) and Abraham et al…”

mentioning

confidence: 99%

Endotoxemia and hepatic injury in a rodent model of hindlimb unloading

Rivera

Tcharmtchi²,

Mendoza³

et al. 2003

Journal of Applied Physiology

View full text Add to dashboard Cite

Hindlimb unloading (HU) is known to induce physiological alterations in various organ systems that mimic some responses observed after exposure to microgravity. In the present study, the effects of up to 4 wk of HU on the liver were assessed in male Wistar rats and two mouse strains: endotoxin-sensitive C57BL/6 mice and endotoxin-resistant C3H/HEJ mice. Plasma levels of endotoxin, a known stimulator of hepatic injury, were measured in portal and systemic blood samples. Endotoxin was elevated by approximately 50% in portal blood samples of mice and rats but was not detectable in systemic blood. This low-grade portal endotoxemia was associated with hepatic injury in rats and C57BL/6 mice as indicated by inflammation and elevated serum transaminase activities. Blood levels of the cytokine TNF-alpha were increased by approximately 50% in C57BL/6 mice; no significant elevation of this cytokine was detected in rats. Messenger RNA levels of the acute-phase proteins serum amyloid A, haptoglobin, and lipopolysaccharide binding protein were significantly enhanced after 3 wk of HU in endotoxin-sensitive rodents. In contrast, no histological changes or significant increases in serum enzyme activity were detected after HU in C3H/HEJ mice despite portal endotoxin levels of 222 +/- 83.4 pg/ml. At the 3-wk time point, expression of acute-phase proteins was not elevated in C3H/HEJ mice; however, expression after 4 wk of HU was similar to endotoxin-sensitive rodents. In conclusion, these findings indicate that HU induced mild portal endotoxemia, which contributed to the observed hepatic injury in endotoxin-sensitive rodents.

show abstract

The Effect of Space Flight Upon Plasma and Tissue Lipids in Rats: The Cosmos Biosatellite Program

Cited by 2 publications

References 0 publications

Metabolic Effects of Prolonged Melatonin Administration and Short-Term Fasting in Laboratory Rats

Metabolic Effects of Prolonged Melatonin Administration and Short-Term Fasting in Laboratory Rats

Endotoxemia and hepatic injury in a rodent model of hindlimb unloading

Contact Info

Product

Resources

About