The Effect of Some Sugars on the Growth of Aspergillus niger

Hamad, Hewa; Alma, Mehmet Hakkı; Ismael, Hero M.; Göçeri, Ali

doi:10.18016/ksujns.28479

Cited by 26 publications

(17 citation statements)

References 20 publications

(14 reference statements)

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“…Diabetic patients are more prone to fungal diseases because of immunosuppressive effects [45]. To see the effect of glucose on the proliferation of fungus and anti-proliferating activity of the ginger extract, the protocol used by Hamad and colleagues was followed with some modifications [46]. Aspergillus fumigatus was plated on potato dextrose agar (PDA) medium and was incubated at 30 • C for 5 days.…”

Section: Antifungal Activity Of Ginger Extract Against Aspergillus Fumentioning

confidence: 99%

Protective Effects of Ginger Extract against Glycation and Oxidative Stress-Induced Health Complications: An In Vitro Study

et al. 2020

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Protein glycation and oxidative stress lead to severe health complications in various diseases including diabetes mellitus. The intake of flavonoid-rich foods has been confirmed previously to have a positive effect on human health. Ginger is an important source of flavonoids and is one of the most widely used traditional medicines in many Asian countries. The aim of this study was to verify the therapeutic potential of methanolic extract from ginger against glycation and other oxidative stress-induced complications using in vitro study. In this study, quantitative estimations of antioxidant components such as total phenolic and flavonoids were determined by UV–visible spectrophotometry. The anti-inflammatory action of the ginger extract was checked by determining its protective action against the denaturation of proteins, anti-proteinase activity and its membrane stabilization effect. The anti-inflammatory action of ginger extract was found to be comparable with reference standard drugs. The antiglycating effect of ginger extract was investigated by placing bovine serum albumin (BSA) with glucose in the presence and absence of ginger extract for two weeks at 37 °C. The incubated samples were analyzed for the number of glycation products, secondary structural changes, aggregation and advanced glycation end products (AGEs) formation by checking browning intensity, determination of aggregation index and Congo red assays. Our findings demonstrated that ginger extract (600 µg/mL) significantly reduced the browning, secondary structural changes, aggregation and AGEs formation. Thus, it can be concluded from these results that ginger extract is a wealthy source of antioxidants and can be used to prevent the glycation and oxidative stress-induced damage of biomolecules in various health complications including inflammation.

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Section: Antifungal Activity Of Ginger Extract Against Aspergillus Fumentioning

confidence: 99%

Protective Effects of Ginger Extract against Glycation and Oxidative Stress-Induced Health Complications: An In Vitro Study

et al. 2020

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“…The media used were MEA as standard media and some modified media (solid, 20 mL/petri dish), the pH was near neutral (around 5.60-6.50), with 50-60 ‰ salinity. The fungus, was incubated for 6,7,8, and 9 days (24 hours in dark and static conditions) at 27 o C as described by Hamad et al (2014).…”

Section: Cultivation Of Fungusmentioning

confidence: 99%

Antibacterial Activities of the Extracts of Sponge-Associated Fungus Trichoderma longibrachiatum against Pathogenic Bacteria

Sedjati

Ambariyanto

Trianto³

et al. 2020

Squalen Bull. Marine Fisheries Postharvest Biotech.

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This study aims to explore the antibacterial potential of a sponge-associated fungus Trichoderma longibrachiatum isolated from Ternate waters, North Maluku, Eastern Indonesia. Various culture media were used to stimulate the production of secondary metabolites in T. longibrachiatum. The isolate was cultured in various media for 6-9 days. Then, the antibacterial activities of the ethyl acetate extracts were assayed against pathogenic bacteria of Multi-Drug Resistant (MDR) strain (Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus cereus). The results showed that all extracts had similar profiles on the thin layer chromatography. However, two of the most potent extracts were produced from the PCA and MEA media for 9 days. These extracts inhibited methicillin-resistant S. aureus (MRSA) (12.48 mm and 12.27 mm); B. cereus (12.11 mm and 12.12 mm); K. pneumoniae (12.40 mm and 10.76 mm); and P. aeruginosa (11.59 mm and 8.69 mm) at concentrations 500 mg/disc. In conclusion, the fungus T. longibrachiatum that was cultured in PCA and MEA media had the potential to produce antibacterial compounds against MDR pathogens and both had similar compounds. Meanwhile, the ethyl acetate extracts from fungus cultured in the TPA and TA media were inactive against all tested bacteria

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“…Therefore, the most favorable combination of four factors that included glucose, beef extract, 1.5 X amino acid concentration and CdCl 2 yielded the best results in terms of both the responses under study. There are many reports of microbial cultures that are accustomed to utilizing varying carbon and nitrogen sources for their optimal growth along with metabolite production [15][16][17] .…”

Section: Fig 5: Pictorial Representation Of (A) Biomass Produced Undmentioning

confidence: 99%

Untitled

2020

IJPSR

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There are many pharmaceutically important compounds from Penicillium sp. that made the fungal genera one of the most important sources for the production of bioactive metabolites. As per the results of our previous study, a bioactive metabolite, P5, from Penicillium rubens JGIPR9 had highly promising cytotoxic and anti-cancer potentials. This prompted us to undertake the current study, so as to optimize the culture conditions of this fungal isolate and thereby to enhance its growth, i.e., biomass (response 1) and production of the anticancer metabolite P5 (response 2). Initially, the single factor method was adopted to screen the individual culture conditions that would enhance the responses under the study. The best factors being CdCl 2 , glucose, amino acid concentrate, and beef extract were subjected to Central Composite Design (CCD) to identify the optimal conditions that enhance the responses. The biomass dry weight ranged from 11.9-24.1 g/L and that of P5 concentration ranged from 257-774 mg/L. The optimal conditions were verified experimentally and 3.24-fold and 12.21-fold increase were observed for responses 1 and 2 respectively in comparison to the basal culture conditions.

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The Effect of Some Sugars on the Growth of Aspergillus niger

Cited by 26 publications

References 20 publications

Protective Effects of Ginger Extract against Glycation and Oxidative Stress-Induced Health Complications: An In Vitro Study

Protective Effects of Ginger Extract against Glycation and Oxidative Stress-Induced Health Complications: An In Vitro Study

Antibacterial Activities of the Extracts of Sponge-Associated Fungus Trichoderma longibrachiatum against Pathogenic Bacteria

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