1958
DOI: 10.1111/j.1399-6576.1958.tb05256.x
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THE EFFECT OF SOME GURARIZING DRUGS IN UNANAESTHETIZED MAN. II: Succinylcholine Iodide and Its Bis‐Monoethyl‐Substituted Derivative in Continuous Intravenous Infusion

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Cited by 8 publications
(6 citation statements)
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“…The finding could also indicate that the phenomenon of tachyphylaxis and the alteration in the mode of action of suxamethonium might be closely related. It has been reported in man that tachyphylaxis develops after repeated or continuous injection of suxamethonium (Poulsen & Hougs, 1958;Payne & Holmdahl, 1959;Katz et al, 1963;Crul et al, 1966;Katz & Ryan, 1969). These reports differ, however, in the percentage of patients who developed tachyphylaxis.…”
mentioning
confidence: 39%
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“…The finding could also indicate that the phenomenon of tachyphylaxis and the alteration in the mode of action of suxamethonium might be closely related. It has been reported in man that tachyphylaxis develops after repeated or continuous injection of suxamethonium (Poulsen & Hougs, 1958;Payne & Holmdahl, 1959;Katz et al, 1963;Crul et al, 1966;Katz & Ryan, 1969). These reports differ, however, in the percentage of patients who developed tachyphylaxis.…”
mentioning
confidence: 39%
“…If suxamethonium is administered repeatedly or continuously either to man or to animals, its neuromuscular blocking activity is reduced as repeated or continuous administrations proceed (Mohelsky & Ruben, 1953;Hodges & Foldes, 1956;Stenberg & Orndahl, 1956;Poulsen & Hougs, 1958;Iwatsuki, Yamada, Ueda, Nishimura & Kanemaru, 1958;Payne & Holmdahl, 1959;Katz, Wolf & Papper, 1963;Crul, Long, Brunner & Coolen, 1966;Katz & Ryan, 1969). This tachyphylaxis has been most frequently studied by the use of single twitch contractions of skeletal muscle; the response of tetanic contractions of skeletal muscle has been less extensively examined in such studies during the administration of suxamethonium.…”
Section: Introductionmentioning
confidence: 99%
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“…The diversity of these changes is great. Thus, an ittoease in artmial bloodpressure has been observed by many authors (4, 22, 25, 33-36, 38, 44, 46, 57, 62-65, 71,91,93,94,99,102,108,117,130,131,137,139,142,143,153,158,162,163,166,170,189,194,199,204,208,212,216,220,222,228,229,244,245,259,260,267,269,274,276,277,281,290,[295][296][297][298]301), while a &crease in arterial bloodpressure m a y also occur…”
mentioning
confidence: 77%
“…203 Its first manifestation is a gradually decreasing sensitivity (tachyphylaxis) to the effects of repeated identical doses. 2 0 1 , 285,317,318,381 This °ln terms of milligrams per kilograrn of body weight. decreased sensitivity to depolarizing relaxants is accompanied by an increased sensitivity to nondepolarizing agents.…”
Section: Neuromuscular Transmission and Neuromuscular Block In Manmentioning
confidence: 99%