1958
DOI: 10.1097/00132586-195812000-00006
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The Effect of Some Curarizing Drugs in Unanaesthetized Man

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Cited by 6 publications
(9 citation statements)
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“…A similar effect has been reported in the cat tenuissimus muscle in vivo (Maclagan, 1962), but in the absence of measurements of plasma concentration of the drug it was attributed to a reduction in the infusion rate. These results in the cat are comparable to those obtained in vivo in the rat (Creese & Maclagan, 1970) and in man (Poulsen & Hougs, 1958 (Creese & Maclagan, 1970) are comparable to those obtained by many authors in isolated muscle from the frog (Gissen & Nastuk, 1966), cat (Maclagan, 1962), rat (Thesleff, 1955;Gibberd, 1966;Harris & Leach, 1970), guinea-pig (Jenden, 1955), rabbit (Jenden, Kamijo & Taylor, 1954) and man (Creese, Dillon, Marshall, Sabawalla, Schneider, Taylor & Zinn, 1957). In vitro, as in vivo, the recovery of the twitch during prolonged application of the drug is critically dependent on the dose (Jenden et al, 1954;Gissen & Nastuk, 1966).…”
Section: Discussionsupporting
confidence: 88%
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“…A similar effect has been reported in the cat tenuissimus muscle in vivo (Maclagan, 1962), but in the absence of measurements of plasma concentration of the drug it was attributed to a reduction in the infusion rate. These results in the cat are comparable to those obtained in vivo in the rat (Creese & Maclagan, 1970) and in man (Poulsen & Hougs, 1958 (Creese & Maclagan, 1970) are comparable to those obtained by many authors in isolated muscle from the frog (Gissen & Nastuk, 1966), cat (Maclagan, 1962), rat (Thesleff, 1955;Gibberd, 1966;Harris & Leach, 1970), guinea-pig (Jenden, 1955), rabbit (Jenden, Kamijo & Taylor, 1954) and man (Creese, Dillon, Marshall, Sabawalla, Schneider, Taylor & Zinn, 1957). In vitro, as in vivo, the recovery of the twitch during prolonged application of the drug is critically dependent on the dose (Jenden et al, 1954;Gissen & Nastuk, 1966).…”
Section: Discussionsupporting
confidence: 88%
“…A similar effect has been reported in the cat tenuissimus muscle in vivo (Maclagan, 1962), but in the absence of measurements of plasma concentration of the drug it was attributed to a reduction in the infusion rate. These results in the cat are comparable to those obtained in vivo in the rat (Creese & Maclagan, 1970) and in man (Poulsen & Hougs, 1958). In all three species therefore application of a constant concentration of depolarizing drugs in vivo does not cause a maintained neuromuscular block.…”
Section: Discussionsupporting
confidence: 85%
“…Sub-maximal stimuli of 9 ms duration at a frequency of 50 Hz were applied for 1.2 s every 6 s and the resultant contractions were recorded with an ink writer through a mechanically operated system. Poulsen & Hougs (1957) also used sub-maximal tetanic stimuli of the median, tibial and peroneal nerves in their study of the effects of various curarising drugs in conscious volunteers.4…”
Section: Mechanism Of Neuromuscular Transmissionmentioning
confidence: 99%
“…203 Its first manifestation is a gradually decreasing sensitivity (tachyphylaxis) to the effects of repeated identical doses. 2 0 1 , 285,317,318,381 This °ln terms of milligrams per kilograrn of body weight. decreased sensitivity to depolarizing relaxants is accompanied by an increased sensitivity to nondepolarizing agents.…”
Section: Neuromuscular Transmission and Neuromuscular Block In Manmentioning
confidence: 99%
“…135 Because of its fleeting action, the potency of SCh cannot be accurately assessed in the absence of an AChE. The potency of several neuromuscular blocking agents in decreasing muscle strength by 75 to 100 per cent on electrical stimulation of the nerves and causing less than 30 per cent reduction in tidal volume in unanesthetized subjects determined by Poulsen and Hougs 317 is summarized in Table III. The head-drop dose of d-Tc and dimTc, respectively, was found to be 0.16 and 0.04 mg. per kilogram in a single subject. 274 All the relaxants investigated had a greater effect on grip strength than on vital …”
Section: Foldesmentioning
confidence: 99%