The effect of somatostatins (SRIF‐14, 25 and 28), galanin and anti‐SRIF on plasma growth hormone levels in Coho salmon (<i>Oncorhynchus kisutch</i>, Walbaum)

Díez, José Manuel Olivares; Giannicot, G.; McLeant, E.; Donaldson, Edward M.

doi:10.1111/j.1095-8649.1992.tb02634.x

Cited by 27 publications

(19 citation statements)

References 23 publications

(24 reference statements)

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“…Diez et al (1992) demonstrated that the passive immunization of coho salmon with the same antiSRIF used in the present study, increased plasma GH levels. In the rat it has been proposed that antiSRIF immunoneutralizes SRIF in the hypophyseal portal vessels before it reaches the pituitary somatotrophs, thereby reducing SRIFs inhibitory action (Chihara et al 1978).…”

Section: Discussionmentioning

confidence: 70%

“…However, there was an apparent delayed response to SOMA-10 treatment. While the reasons for this remain obscure, Diez et al (1992) observed that the timecourse of GH response, following injection of coho salmon with SOMA-10, was short; plasma GH levels being the same in both treated and control fish after only 30 min post-ip injection. Further, in the same study, the magnitude of plasma GH increase, following SOMA-10 injection, was found to be relatively low, certainly lower than that reported for mammals (Thomas et al 1985).…”

Section: Discussionmentioning

confidence: 93%

“…For example, invariant SRIF-14 together with SRIF-25 and SRIF-28 have been isolated and characterised from the coho salmon, Oncorhynchus kisutch (Plisetskaya et al 1986). More recently Diez et al (1992) reported that these SRIFs differed in their activity with respect to their inhibition of GH secretion in coho salmon, with SRIF-14 being the most active. However, while it is well established that a major physiological function of SRIF is in the control of GH release (review : Harvey 1993), to date no study has demonstrated a growth-inhibiting effect of exogenous SRIF in teleosts.…”

Section: Introductionmentioning

confidence: 99%

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Antisomatostatin-induced growth acceleration in chinook salmon (Oncorhynchus tshawytscha)

Mayer¹,

McLean²,

Kieffer

et al. 1994

Fish Physiol Biochem

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Since somatostatin (SRIF) inhibits the release of growth hormone (GH), its immunoneutralization may provide an alternative to GH therapy as a means of enhancing somatic growth in fish. The present study examined the feasibility of accelerating growth in juvenile chinook salmon by means of antiSRIF administration. Yearling salmon of Nicola River stock (BC, Canada) were injected intraperitoneally every 5 days, for a total of 40 days, with either SRIF (1 μg g-1 body wt.), antiSRIF (SOMA-10, 1 μg g(-1)), recombinant bovine GH (rbGH, 2.5 μg g(-1)), recombinant porcine GH (rpGH, 2.5 μg g(-1)) or saline (controls). No significant differences were observed in length, weight or final condition factor (k) between the SRIF-treated and control fish over the experimental period. However, the fish treated with the antiSRIF were significantly (p ≤ 0.05) longer and heavier than the control salmon after 25 and 30 days respectively. Furthermore, antiSRIF treatment caused a lowering in k when compared to the control salmon. Fish injected with rbGH or rpGH were significantly longer and heavier than all other groups (p ≤ 0.05), after only 5 days. GH treated groups also returned higher k when compared against all other treatments (p ≤ 0.05). No differences were observed in growth between the two rGH treatments over the experimental period.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antisomatostatin-induced growth acceleration in chinook salmon (Oncorhynchus tshawytscha)

Mayer¹,

McLean²,

Kieffer

et al. 1994

Fish Physiol Biochem

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“…At the level of the pituitary, PPSS-I-derived peptides such as SS-14 are well known for their inhibition of GH release in mammals and fishes (Marchant et al, 1987;Marchant & Peter, 1989;Harvey, 1993). The current results showing that intraperitoneal injection of rainbow trout with SS-14 was (Sweeting & McKeown, 1986;Diez et al, 1992) and goldfish Carassius auratus (L.) (Cook & Peter, 1984). However, as noted previously (Holloway et al, 1997), the interaction between plasma SS-14 and GH secretion is potentially complex, and the relative importance of the plasma SS-14 pool compared to hypothalamicallyderived SS-14 in modulating GH secretion is not known.…”

Section: Discussionmentioning

confidence: 56%

Somatostatin inhibits growth of rainbow trout

Very

Knutson

Kittilson

et al. 2001

Journal of Fish Biology

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Implantation of rainbow trout Oncorhynchus mykiss with somatostatin‐14 (SS‐14) for 20 days resulted in reduced food conversion as well as significant growth retardation compared to controls. Relative growth as mass was reduced by 20%, whereas relative growth by length was reduced by 45%. A single intraperitoneal injection of SS‐14 reduced plasma levels of growth hormone (GH), insulin‐like growth factor‐1 (IGF‐I) and insulin. SS‐14 injection also reduced [35S]‐sulphate incorporation into gill cartilage compared to saline‐injected fish. In addition, in vitro incubation of gill cartilage with SS‐14 reduced [35S]‐sulphate incorporation in a doserelated manner. These results indicate that SS‐14 inhibits growth of rainbow trout and suggests that SS‐14, in addition to influencing GH, may play an extra‐pituitary role in the modulation of the GH‐IGF‐I axis.

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“…The fish were selected randomly to receive an intraperitoneal injection of 5 ng g −1 body mass (BM) of SS‐14 (American Peptide Company, Sunnyvale, CA, U.S.A.) ( n = 5), 50 ng g −1 BM of SS‐14 ( n = 5), or saline ( n = 5). These doses were chosen based on a previous study that administered SS‐14 to coho salmon (Diez et al ., 1992). An insulin syringe (0·3 ml) fitted with a 30‐gauge needle was used to administer the treatments intra‐peritoneally (i.p.).…”

Section: Methodsmentioning

confidence: 99%

Effects of administration of somatostatin‐14 and immunoneutralization of somatostatin on endocrine and growth responses in rainbow trout

Peterson

Simpson

Cain

et al. 2003

Journal of Fish Biology

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Injection of somatostatin‐14 (SS‐14) at 5 ng g−1 body mass (BM) into rainbow trout Oncorhynchus mykiss decreased (P < 0·05, cubic, r2 = 0·54) levels of growth hormone (GH) (1·5 ± 0·9 ng ml−1v. 6·6 ± 0·6 ng ml−1) over time when compared to controls. Somatostatin‐14 at 50 ng g−1 BM also decreased (P = 0·064, quadratic; r2 = 0·30) levels of GH (3·6 ± 2·1 ng ml−1v. 6·6 ± 0·6 ng ml−1) over time compared to controls. In a second study, passive immunization against SS‐14 (1 : 25 dose) increased (P = 0·10, cubic, r2 = 0·12) levels of GH (11·0 ± 4·8 ng ml−1v. 5·2 ± 1·4 ng ml−1) over time. Passively immunizing against SS‐14 (1 : 50 dose) increased (P < 0·05, cubic, r2 = 0·10) levels of GH (8·2 ± 2·3 ng ml−1v. 5·2 ± 1·4 ng ml−1) over time compared to controls. Overall, in the active immunization study there was no difference (P > 0·10) in specific growth rate (G) or feed conversion ratio (FCR) between the three treatment groups during the 9 weeks of the study. Only four of the fish immunized against SS‐14, however, developed antibody titres against SS. Compared to controls, these fish exhibited a G of 0·89 ± 0·09 v. 0·56 ± 0·09% per 3 weeks and FCR of 0·80 ± 0·04 v. 1·20 ± 0·05 g g−1. In SS‐14 immunized fish, levels of GH decreased (P < 0·05) by day 63 while levels of insulin like growth factor‐I (IGF‐I) increased (P < 0·05) by day 42 and 63. These results indicate the hypothalamic hormone SS‐14 regulates GH secretion similarly in rainbow trout as it does in mammals. Active immunization against SS‐14 could improve growth performance in rainbow trout but enhanced G and FCR is dependent upon generation of antibody titres.

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The effect of somatostatins (SRIF‐14, 25 and 28), galanin and anti‐SRIF on plasma growth hormone levels in Coho salmon (Oncorhynchus kisutch, Walbaum)

Cited by 27 publications

References 23 publications

Antisomatostatin-induced growth acceleration in chinook salmon (Oncorhynchus tshawytscha)

Antisomatostatin-induced growth acceleration in chinook salmon (Oncorhynchus tshawytscha)

Somatostatin inhibits growth of rainbow trout

Effects of administration of somatostatin‐14 and immunoneutralization of somatostatin on endocrine and growth responses in rainbow trout

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