The effect of somatostatin analogues on postoperative outcomes following pancreatic surgery: A meta-analysis

Abstract

BackgroundLeakage from the pancreatic stump is a leading cause of morbidity following pancreatic surgery. It is essential to evaluate the effect of somatostatin analogues (SAs) following pancreatic surgery by analyzing all recent clinical trials.Data sourcesWe performed a literature search in the Medline, EMBASE, Cochrane Central Register of Controlled Trials and Web of Science databases up to May 29, 2016. Publication bias was assessed with Egger’s test. Study quality was assessed using the Jadad Composite Scale.ConclusionsTwelve clinical trials involving 1703 patients from Jan 1st, 2000 to May 29th, 2016 were included in the study. With improvements in surgical management and peri-operative patient care, prophylactic use of somatostatin and its analogues reduced the overall incidence of pancreatic fistulas (RR 0.72, 95% CI 0.55–0.94; p = 0.02) and decreased the post-operative hospital stay after pancreatic surgery (the weighted mean difference was -1.06, 95% CI-1/88 to -0.23; p = 0.01). Other post-operative outcomes did not change significantly with the use of somatostatin analogues.

Visual mismatch negativity to disappearing parts of objects and textures

“…an event with 1.0 probability) does not elicit vMMN [2, 3, 5, 6]. Furthermore, this interpretation of the previous study [4] was closely connected to object-related representation, because we considered that the environmental model consisted of representations of whole diamonds. The aim of the present study was to replicate this result, and to investigate the object-related aspect of our interpretation.…”

“…As Fig 2 shows, over the posterior locations deviant object offset , texture offset and texture onset elicited a negative deviant minus standard posterior difference potential, but object onset did not elicit posterior negativity. To replicate the results [4] we calculated vMMN amplitude within the range of significant difference of the previous study (120–202 ms). We calculated an occipital ROI from O1, Oz and O2 locations.…”

“…The experimental stimuli of the object condition and other aspects of the study were identical to our previous study [4]. As a summary, events were presented on a 19-inch CRT monitor (Flatron 915 FT Plus, 75 Hz refresh rate) from a 1.4 m distance using the Cogent 2000 MATLAB toolbox.…”

“…On the basis of the results of our previous study [4] we calculated an occipital ROI (O1, Oz, O2) from the deviant minus standard difference potentials. In the previous study vMMN emerged at the occipital locations within the 120–202 ms range, therefore in the present study we calculated the mean activity within this range.…”

“…In our previous study [4] we obtained vMMN to the offset of irregularly vanishing parts of objects. In particular, diamonds with diameters were presented during the inter-event interval.…”