The effect of sol–gel-formed calcium phosphate coatings on bone ingrowth and osteoconductivity of porous-surfaced Ti alloy implants

Nguyen, HQ; Deporter, Douglas; Pilliar, Robert M.; Valiquette, Nancy; Yakubovich, Raisa

doi:10.1016/s0142-9612(03)00607-0

Cited by 160 publications

(82 citation statements)

References 23 publications

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“…For these reasons, the third group was modificated with a ceramic material which includes Ca-P, HA. It is well known that HA is a good biocompatible material [17,18]. In vivo studies especially these two materials are known for their good osteoconductivity (for the early stage of osteogenesis).…”

Section: Implant Specimensmentioning

confidence: 99%

Measurement and image processing evaluation of surface modifications of dental implants G4 pure titanium created by different techniques

Bulutsuz¹,

Demircioglu²,

Böğrekçi³

et al. 2015

AIP Conference Proceedings

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Abstract. Foreign substances and organic tissue interaction placed into the jaw in order to eliminate tooth loss involves a highly complex process. Many biological reactions take place as well as the biomechanical forces that influence this formation. Osseointegration denotes to the direct structural and functional association between the living bone and the load-bearing artificial implant's surface. Taking into consideration of the requirements in the manufacturing processes of the implants, surface characterizations with high precise measurement techniques are investigated and thus long-term success of dental implant is emphasized on the importance of these processes in this study. In this research, the detailed surface characterization was performed to identify the dependence of the manufacturing techniques on the surface properties by using the image processing methods and using the scanning electron microscope (SEM) for morphological properties in 3D and Taylor Hobson stylus profilometer for roughness properties in 2D. Three implant surfaces fabricated by different manufacturing techniques were inspected, and a machined surface was included into the study as a reference specimen. The results indicated that different surface treatments were strongly influenced surface morphology. Thus 2D and 3D precise inspection techniques were highlighted on the importance for surface characterization. Different image analyses techniques such as Dark-light technique were used to verify the surface measurement results. The computational phase was performed using image processing toolbox in Matlab with precise evaluation of the roughness for the implant surfaces. The relationship between the number of black and white pixels and surface roughness is presented. FFT image processing and analyses results explicitly imply that the technique is useful in the determination of surface roughness. The results showed that the number of black pixels in the image increases with increase in surface roughness.

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Section: Implant Specimensmentioning

confidence: 99%

Measurement and image processing evaluation of surface modifications of dental implants G4 pure titanium created by different techniques

Bulutsuz¹,

Demircioglu²,

Böğrekçi³

et al. 2015

AIP Conference Proceedings

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“…Beside biocompatibility, coated implant also shows improvement on the mechanical properties due to the combination of hard surface and ductile substrate. Numerous coating methods have been employed to improve bio-compatibility of metal implant including plasma spray (Schrooten, 2000) and sol-gel (Nguyen, 2004). Among the processes, plasma spray has been the most popular method for the coating process of bioapatite on Ti substrate.…”

Section: Coatingmentioning

confidence: 99%

Metals for Biomedical Applications

Hermawan¹,

Ramdan²,

Djuansjah³

2011

Biomedical Engineering - From Theory to Applications

173

125

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Biomedical Engineering -From Theory to Applications 412 visible under X-ray imaging. Most of artificial implants are subjected to loads, either static or repetitive, and this condition requires an excellent combination of strength and ductility. This is the superior characteristic of metals over polymers and ceramics. Specific requirements of metals depend on the specific implant applications. Stents and stent grafts are implanted to open stenotic blood vessels; therefore, it requires plasticity for expansion and rigidity to maintain dilatation. For orthopaedic implants, metals are required to have excellent toughness, elasticity, rigidity, strength and resistance to fracture. For total joint replacement, metals are needed to be wear resistance; therefore debris formation from friction can be avoided. Dental restoration requires strong and rigid metals and even the shape memory effect for better results. In overall, the use of biomaterials in clinical practice should be approved by an authoritative body such as the FDA (United States Food and Drug Administration). The proposed biomaterial will be either granted Premarket Approval (PMA) if substantially equivalent to o n e u s e d b e f o r e F D A l e g i s l a t i o n o f 1 9 7 6 , o r h a s t o g o t h r o u g h a s e r i e s o f g u i d e d biocompatibility assessment. Common metals used for biomedical devicesUp to now, the three most used metals for implants are stainless steel, CoCr alloys and Ti alloys. The first stainless steel used for implants contains ~18wt% Cr and ~8wt% Ni makes it stronger than the steel and more resistant to corrosion. Further addition of molybdenum (Mo) has improved its corrosion resistance, known as type 316 stainless steel. Afterwards, the carbon (C) content has been reduced from 0.08 to 0.03 wt% which improved its corrosion resistance to chloride solution, and named as 316L. Titanium is featured by its light weight. Its density is only 4.5g/cm 3 compared to 7.9g/cm 3 for 316 stainless steel and 8.3g/cm 3 for cast CoCrMo alloys (Brandes and Brook, 1992). Ti and its alloys, i.e. Ti6Al4V are known for their excellent tensile strength and pitting corrosion resistance. Titanium alloyed with Ni, i.e. Nitinol, forms alloys having shape memory effect which makes them suitable in various applications such as dental restoration wiring. In dentistry, precious metals and alloys often used are Au, Ag, Pt and their alloys. They possess good castability, ductility and resistance to corrosion. Included into dental alloys are AuAgCu system, AuAgCu with the addition of Zn and Sn known as dental solder, and AuPtPd system used for porcelain-fused-to-metal for teeth repairs. CoCr alloys have been utilised for many decades in making artificial joints. They are generally known for their excellent wear resistance. Especially the wrought CoNiCrMo alloy has been used for making heavily loaded joints such as ankle implants (Figure 1). Other metals used for implants include tantalum (Ta), amorphous alloys and biodegradable metals. Tantalum which has excell...

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“…Several studies have demonstrated greater osteoconductivity of Ti implants that were subjected to thermal and chemical treatments. These treatments, called biomimetics, are specific processes capable of forming in vitro on the implant surface by ion precipitation using calcium phosphates, such as hydroxyapatite (Ca5(PO4)3(OH)) [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…Bioactive coating on the porous surface is an attractive method to improve the quality of the bone-implant interface, particularly in the initial stages of healing [21]. Implant topography and surface chemical structure are two aspects considered important for osseointegration, since topography is related to fibrin clot retention and osteoprogenitor cell migration, while the chemical structure influences the surface adsorption of proteins that promote adhesion and the activation of osteoprogenitor cells [20].…”

Section: Introductionmentioning

confidence: 99%

Porous Titanium by Powder Metallurgy for Biomedical Application: Characterization, Cell Citotoxity and in vivo Tests of Osseointegration

Vasconcellos¹,

Carvalho²,

Prado³

et al. 2012

Biomedical Engineering - Technical Applications in Medicine

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The effect of sol–gel-formed calcium phosphate coatings on bone ingrowth and osteoconductivity of porous-surfaced Ti alloy implants

Cited by 160 publications

References 23 publications

Measurement and image processing evaluation of surface modifications of dental implants G4 pure titanium created by different techniques

Measurement and image processing evaluation of surface modifications of dental implants G4 pure titanium created by different techniques

Metals for Biomedical Applications

Porous Titanium by Powder Metallurgy for Biomedical Application: Characterization, Cell Citotoxity and in vivo Tests of Osseointegration

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