The Effect of Sodium Alendronate Gel on Osseointegration of Submerged Dental Implants

Abstract

INTRODUCTION: A plenty of materials have been used to increase the success rate, decrease time needed for osseointegration, stimulate bone formation around dental implants. Bisphosphonates increase bone mineral density by inhibiting osteoclast-mediated bone resorption. Alendronate sodium hydrate is a bisphosphonate that potently inhibits bone resorption and is used to treat osteoporosis. A 1% sodium alendronate gel is manufactured and tested in order to accelerate osseointegration around dental implants. OBJECTIVES: This study aims to compare clinically and radiographically the osseointegration for 2 groups of submerged dental implants both in upper anterior and premolar region, first group with the use of local sodium alendronate gel prior to placement of dental implant and the second group without. MATERIALS AND METHODS: A clinical trial on 24 implants divided into 2 groups indicated for dental implant placement in the upper anterior and premolar region selected from the outpatient clinic of the Oral and Maxillofacial department, Faculty of Dentistry, Alexandria University. For the test group 12 implants were placed with sodium alendronate gel just prior to implant placement. For control group 12 implants were placed without sodium alendronate gel. RESULTS: On the 12 week the resonance frequency analysis (RFA) median records were (55.50, 54.0) and the Mean ± SD (55.08 ± 4.94, 54.67 ± 5.69) for the control group and test group, respectively. The bisphosphonate-coated implants showed an increase in implant stability from 0 to 12 weeks more than the control's measures. On the 12 week, the mean peri-implant bone density value was 1417.92 ± 310.54 for control group and 1550.25 ± 286.15 for test group. These increases in the bone density were higher in test group than the control group. CONCLUSIONS: Using sodium alendronate gel with delayed implant placement could enhance the osseointegration around dental implants.

A New Insight into Coating’s Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant

“…Recently, numerous in vitro, in vivo, and clinical studies about coatings that mitigate implant response, i.e., coatings induced by bone’s immune system, have been reported [ 1 , 2 , 3 , 4 ]. Since the implantation procedure destroys part of the bones and surrounding tissues and often evokes an inflammatory reaction, thus limiting the implant response, researchers are focused on improving the osseonintegration of implants by using pharmaceutical compounds, like bisphosphonates, as bioactive and osteoinductive coatings [ 1 , 2 , 4 , 25 , 26 , 27 , 28 , 29 ]. The bisphosphonates (BP) class of synthetic drugs is frequently used for the treatment of bone diseases; osteoporosis, bone cancer, osteopenia, and Paget’s disease [ 2 , 7 , 30 , 31 , 32 ].…”

Impact of Alendronate Gel on Bone Density in Immediately Loaded Dental Implants: A Clinical Study

“…(11)(12)(13) Sodium alendronate gel was manufactured and tested to accelerate osseointegration around dental implants with the concept of positive influence of bone remodeling adjacent to the dental implant, avoiding the undesirable systemic side effects. (1,14) Bone density is the amount of bone tissue defined in a certain volume of bone. Several approaches have been introduced as valid tools for measuring jaw bones and other skeletal bones density such as the spine and femur.…”