The Effect of SOCS2 Polymorphisms on Type 2 Diabetes Mellitus Susceptibility and Diabetic Complications in the Chinese Han Population

Abstract

<jats:title>Abstract</jats:title> <jats:p><jats:italic>Propose</jats:italic>: We explored the effect of <jats:italic>SOCS2</jats:italic> polymorphisms on the development of type 2 diabetes mellitus (T2DM) and diabetic complications.<jats:italic>Methods</jats:italic>: The subjects consisted of 500 T2DM patients and 501 healthy volunteers. Five variants in <jats:italic>SOCS2</jats:italic> were genotyped by Agena MassARRAY system. Logistic regression analysis was utilized to calculate the odds ratio (OR) and 95% confidence intervals (95% CI).<jats:italic>Results: </jats:italic>Rs3825199 (OR = 1.44, <jats:italic>p </jats:italic>= 0.007), rs11107116 (OR = 1.39, <jats:italic>p </jats:italic>= 0.014) and rs10492321 (OR = 1.48, <jats:italic>p </jats:italic>= 0.004) had the increased T2DM risk. Moreover, the contribution of <jats:italic>SOCS2</jats:italic> polymorphisms to T2DM risk was associated with age, gender, smoking and drinking and BMI. <jats:italic>SOCS2</jats:italic> variants also had the reduced risk for T2DM patients with diabetic nephropathy, diabetic retinopathy and coronary heart disease.<jats:italic>Conclusions: </jats:italic>This study firstly reported that rs3825199, rs11107116 and rs10492321 in <jats:italic>SOCS2</jats:italic> conferred to the increased risk for T2DM occurrence in the Chinese Han population.</jats:p>